The 3D protein of CVB3 is modified by K48-linked polyubiquitin chain. by Yao Wang (102387)

Bead-spring model for linear DNA. by Fatema Tuz Zohra (11378812)

Inotodiol decreases clone formation in HCC cells. by Yushuang Xing (20636685)

“…In addition, inotodiol showed to induce apoptosis, characterized by an increase in Bax expression, a decrease in Bcl-2, Bcl-XL and MCL1 expression, the initiation of cleaved PARP1 and cleaved caspase 3, and inhibition of the MAPK/ERK pathway. …”

Inotodiol decreases clone formation in HCC cells. by Yushuang Xing (20636685)

Quinoline-Based DNA Methyltransferase Inhibitors Featuring Basic Side Chains: Design, Synthesis, and Insight in Biochemical and Anticancer Cell Properties by Clemens Zwergel (1307868)

“…In isogenic HCT-116 P53^–/– cells, <b>14</b> exhibited reduced antiproliferative activity, lower apoptosis, and decreased levels of cleaved Caspase 3, P53, and γH2AX, confirming its P53-dependent mechanism of action linked to DNA damage.…”

Data Sheet 1_Comparison of carbonic anhydrase-IX-targeted trifunctional radioligands between linear- and branched-chain arrangements.pdf by Kazuma Nakashima (11383055)

“…The introduction of an albumin binder (ALB) to radioligands can delay their renal clearance, resulting in increased radioactivity delivered to tumors and decreased renal uptake of radioligands. In this study, we designed novel CA-IX-targeted trifunctional radioligands consisting of imidazothiadiazole sulfonamide (IS) as a CA-IX-targeted ligand, DOTA as a chelator with four free carboxylic groups, and lysine-conjugated 4-(p-iodophenyl)butyric acid (Lys-IPBA) as ALB, with IS-[¹¹¹In]In-DOTADG-ALB in a linear-chain arrangement and [¹¹¹In]In-DOTAGA-ALB-IS in a branched-chain arrangement. …”

Factors associated with the hemoglobin level stratified by age group: Linear regression. by Alejandro Rojas Chaves (20614814)

Linear regression equation and concentration range of each SCFAs standard. by Shudan Liu (7049483)

IFN-γ and several PARP genes are upregulated in infected olfactory bulbs of JHMV infected mice. by Catherine M. Kerr (21492574)

PARP9 knockdown promotes apoptosis and DNA damage. by Yating Li (1819822)

“…(E) DNA damage in GC cells significantly increased post-PARP9 knockdown as determined by comet assay. (F) The anti-DNA damage capacity of GC cells decreased markedly following reduction of PARP9 expression. …”

Liver Lipidomics, Histology, Transcriptomics, and Clinical Chemistry of Rats Intraperitoneally Treated with Fumonisin B1 for 5 days by András Szabó (21439528)

Subjects:

Data Sheet 1_Imaging-based assessment of response to olaparib in platinum-sensitive relapsed ovarian cancer patients.pdf by Maria Delgado-Ortet (8840702)

“…In this work, we developed noninvasive imagingbased measurements of spatial and longitudinal heterogeneity in a retrospective analysis of a phase 2 non-randomized study of germline BRCA1/BRCA2 mutated (gBRCAm) ovarian cancer patients treated with combination of PARP inhibitors (PARPi) and immune checkpoint inhibitors (ICIs).…”

Effect of carabrone on mitochondrial respiratory chain complex V (ATP synthase). by Xingyu Ren (7358867)

Cohort Evidence Links Phthalate Exposure to Early Onset of Puberty in Chinese Girls by Yao Yao (335996)

“…Girls’ age of onset puberty has decreased globally in recent years. Emerging evidence suggests that exposure to phthalate esters (PAEs) could play a role in this trend. …”

PARP cleavage analysis of sgCtrl and <i>IRF1</i> KO cells across conditions with and without vaccinia virus infection. by Tyron Chang (9922533)

Descriptive statistics. by Hiroki Takahashi (21598)

“…<div><p>While part-time employees constitute the primary workforce in the chain restaurant industry, their retention has become crucial in developed countries, especially Japan, due to labor shortages resulting from the declining birthrate and aging population. …”

Topics and labels. by Hiroki Takahashi (21598)

“…<div><p>While part-time employees constitute the primary workforce in the chain restaurant industry, their retention has become crucial in developed countries, especially Japan, due to labor shortages resulting from the declining birthrate and aging population. …”

Correlation matrix. by Hiroki Takahashi (21598)

“…<div><p>While part-time employees constitute the primary workforce in the chain restaurant industry, their retention has become crucial in developed countries, especially Japan, due to labor shortages resulting from the declining birthrate and aging population. …”

Table 1_PARP inhibition increases sensitivity to cisplatin in non-small-cell lung carcinoma via the induction of TET-dependent hydroxymethylation.xlsx by Nevena Grdović (394542)

“…Treatment of A549 cells with niraparib resulted in decreased PARP activity, increased 5hmC level, and synergism with cisplatin by promoting cisplatin-induced apoptosis. …”

Data Sheet 1_PARP inhibition increases sensitivity to cisplatin in non-small-cell lung carcinoma via the induction of TET-dependent hydroxymethylation.pdf by Nevena Grdović (394542)

“…Treatment of A549 cells with niraparib resulted in decreased PARP activity, increased 5hmC level, and synergism with cisplatin by promoting cisplatin-induced apoptosis. …”