Search alternatives:
greater decrease » greatest decrease (Expand Search), greater increase (Expand Search), greater disease (Expand Search)
linked decrease » marked decrease (Expand Search)
linear decrease » linear increase (Expand Search)
a greater » _ greater (Expand Search), far greater (Expand Search)
greater decrease » greatest decrease (Expand Search), greater increase (Expand Search), greater disease (Expand Search)
linked decrease » marked decrease (Expand Search)
linear decrease » linear increase (Expand Search)
a greater » _ greater (Expand Search), far greater (Expand Search)
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Quinoline-Based DNA Methyltransferase Inhibitors Featuring Basic Side Chains: Design, Synthesis, and Insight in Biochemical and Anticancer Cell Properties
Published 2025“…In isogenic HCT-116 P53<sup>–/–</sup> cells, <b>14</b> exhibited reduced antiproliferative activity, lower apoptosis, and decreased levels of cleaved Caspase 3, P53, and γH2AX, confirming its P53-dependent mechanism of action linked to DNA damage.…”
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Data Sheet 1_Comparison of carbonic anhydrase-IX-targeted trifunctional radioligands between linear- and branched-chain arrangements.pdf
Published 2025“…The introduction of an albumin binder (ALB) to radioligands can delay their renal clearance, resulting in increased radioactivity delivered to tumors and decreased renal uptake of radioligands. In this study, we designed novel CA-IX-targeted trifunctional radioligands consisting of imidazothiadiazole sulfonamide (IS) as a CA-IX-targeted ligand, DOTA as a chelator with four free carboxylic groups, and lysine-conjugated 4-(p-iodophenyl)butyric acid (Lys-IPBA) as ALB, with IS-[<sup>111</sup>In]In-DOTADG-ALB in a linear-chain arrangement and [<sup>111</sup>In]In-DOTAGA-ALB-IS in a branched-chain arrangement. …”
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Light-Controlled Anticancer Activity and Cellular Uptake of a Photoswitchable Cisplatin Analogue
Published 2024“…The <i>trans</i> photoisomer was bound stronger by bovine serum albumin and induced a greater decrease in cellular glutathione levels than the <i>cis</i> photoisomer.…”
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Light-Controlled Anticancer Activity and Cellular Uptake of a Photoswitchable Cisplatin Analogue
Published 2024“…The <i>trans</i> photoisomer was bound stronger by bovine serum albumin and induced a greater decrease in cellular glutathione levels than the <i>cis</i> photoisomer.…”
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Light-Controlled Anticancer Activity and Cellular Uptake of a Photoswitchable Cisplatin Analogue
Published 2024“…The <i>trans</i> photoisomer was bound stronger by bovine serum albumin and induced a greater decrease in cellular glutathione levels than the <i>cis</i> photoisomer.…”