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largest decrease » larger decrease (Expand Search), marked decrease (Expand Search)
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a largest » _ largest (Expand Search), a large (Expand Search), a latest (Expand Search)
largest decrease » larger decrease (Expand Search), marked decrease (Expand Search)
linked decrease » marked decrease (Expand Search)
linear decrease » linear increase (Expand Search)
a largest » _ largest (Expand Search), a large (Expand Search), a latest (Expand Search)
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Quinoline-Based DNA Methyltransferase Inhibitors Featuring Basic Side Chains: Design, Synthesis, and Insight in Biochemical and Anticancer Cell Properties
Published 2025“…In isogenic HCT-116 P53<sup>–/–</sup> cells, <b>14</b> exhibited reduced antiproliferative activity, lower apoptosis, and decreased levels of cleaved Caspase 3, P53, and γH2AX, confirming its P53-dependent mechanism of action linked to DNA damage.…”
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Data Sheet 1_Comparison of carbonic anhydrase-IX-targeted trifunctional radioligands between linear- and branched-chain arrangements.pdf
Published 2025“…The introduction of an albumin binder (ALB) to radioligands can delay their renal clearance, resulting in increased radioactivity delivered to tumors and decreased renal uptake of radioligands. In this study, we designed novel CA-IX-targeted trifunctional radioligands consisting of imidazothiadiazole sulfonamide (IS) as a CA-IX-targeted ligand, DOTA as a chelator with four free carboxylic groups, and lysine-conjugated 4-(p-iodophenyl)butyric acid (Lys-IPBA) as ALB, with IS-[<sup>111</sup>In]In-DOTADG-ALB in a linear-chain arrangement and [<sup>111</sup>In]In-DOTAGA-ALB-IS in a branched-chain arrangement. …”
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Cohort Evidence Links Phthalate Exposure to Early Onset of Puberty in Chinese Girls
Published 2025“…Girls’ age of onset puberty has decreased globally in recent years. Emerging evidence suggests that exposure to phthalate esters (PAEs) could play a role in this trend. …”
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Trust change by gender.
Published 2025“…Results indicate that respondnatds from North America and Europe Experienced an increase in trust where as Africa and South America Witnessed a decline in trust. Males exhibited a greater decline in trust than females (p = 0.038), and undergraduate degree holders showed the largest decrease (p = 0.001). …”
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Trust change by age group.
Published 2025“…Results indicate that respondnatds from North America and Europe Experienced an increase in trust where as Africa and South America Witnessed a decline in trust. Males exhibited a greater decline in trust than females (p = 0.038), and undergraduate degree holders showed the largest decrease (p = 0.001). …”
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Trust change by education level.
Published 2025“…Results indicate that respondnatds from North America and Europe Experienced an increase in trust where as Africa and South America Witnessed a decline in trust. Males exhibited a greater decline in trust than females (p = 0.038), and undergraduate degree holders showed the largest decrease (p = 0.001). …”
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Trust change by source of science information.
Published 2025“…Results indicate that respondnatds from North America and Europe Experienced an increase in trust where as Africa and South America Witnessed a decline in trust. Males exhibited a greater decline in trust than females (p = 0.038), and undergraduate degree holders showed the largest decrease (p = 0.001). …”
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Descriptive statistics.
Published 2024“…<div><p>While part-time employees constitute the primary workforce in the chain restaurant industry, their retention has become crucial in developed countries, especially Japan, due to labor shortages resulting from the declining birthrate and aging population. …”