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linked decrease » linear decrease (Expand Search)
marked decrease » marked increase (Expand Search)
chain linked » having linked (Expand Search), class linked (Expand Search), chain index (Expand Search)
linked decrease » linear decrease (Expand Search)
marked decrease » marked increase (Expand Search)
chain linked » having linked (Expand Search), class linked (Expand Search), chain index (Expand Search)
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Quinoline-Based DNA Methyltransferase Inhibitors Featuring Basic Side Chains: Design, Synthesis, and Insight in Biochemical and Anticancer Cell Properties
Published 2025“…In isogenic HCT-116 P53<sup>–/–</sup> cells, <b>14</b> exhibited reduced antiproliferative activity, lower apoptosis, and decreased levels of cleaved Caspase 3, P53, and γH2AX, confirming its P53-dependent mechanism of action linked to DNA damage.…”
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ROS, K<sup>+</sup> efflux and cathepsin B are required for NLRP3 activation.
Published 2025Subjects: -
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Eggs jointly coordinate a caspase-1 and caspase-8 dependent pyroptotic cell death.
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The loss of NLRP3 and AIM2 results in reduced Th17 and enhanced Th2 cytokine responses.
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Gsdmd deficiency reduces myeloid cell recruitment to the liver during schistosome infection.
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related to Fig 4. ROS, K+ efflux and cathepsin B do not affect TNFα production in response to eggs.
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Egg-induced IL-1β and IL-17 production is dependent on both Caspase-1 and Caspase-8.
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