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    Design, Synthesis, and Biological Evaluation of [1,2,5]Oxadiazolo[3,4‑<i>b</i>]pyridin-7-ol as Mitochondrial Uncouplers for the Treatment of Obesity and Metabolic Dysfunction-Assoc... by Mary A. Foutz (20361830)

    Published 2024
    “…Pharmacokinetic studies indicated a half-life of 2 h, <i>C</i><sub>max</sub> of 35 μM, and no observed adverse effects at 1,000 mg kg<sup>–1</sup> dose in mice. In a Gubra-Amylin (GAN) mouse model of MASH, <b>SHO1122147</b> was efficacious in decreasing body weight and liver triglyceride levels at 200 mg kg<sup>–1</sup> day<sup>–1</sup> without changes in body temperature. …”
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