Search alternatives:
largest decrease » marked decrease (Expand Search)
larger decrease » marked decrease (Expand Search)
nm decrease » nn decrease (Expand Search), _ decrease (Expand Search), a decrease (Expand Search)
1 nm » 5 nm (Expand Search), 1 mm (Expand Search), 3 nm (Expand Search)
largest decrease » marked decrease (Expand Search)
larger decrease » marked decrease (Expand Search)
nm decrease » nn decrease (Expand Search), _ decrease (Expand Search), a decrease (Expand Search)
1 nm » 5 nm (Expand Search), 1 mm (Expand Search), 3 nm (Expand Search)
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Photooxidation and Cleavage of Ethynylated 9,10-Dimethoxyanthracenes with Acid-Labile Ether Bonds
Published 2025Subjects: -
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Synthesis and Biological Evaluation of MEK/mTOR Multifunctional Inhibitors as Novel Anticancer Agents
Published 2025“…A series of mTOR inhibitor analogs of AZD8055 and AZD2014 were designed to allow for covalent linking to a potent MAPK kinase (MEK) inhibitor to produce a single, bivalent chemical entity. Dual-acting agents (i.e., compound LP-65) were synthesized displaying high in vitro inhibition of both MEK (IC<sub>50</sub> = 83.2 nM) and mTOR (IC<sub>50</sub> = 40.5 nM). …”
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