Showing 1 - 20 results of 166 for search '(( ct ((marked decrease) OR (larger decrease)) ) OR ( via ca decrease ))', query time: 0.43s Refine Results
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    Data Sheet 1_Long-term gabapentin treatment impairs cognitive function in aged mice via tau hyperphosphorylation.docx by Suyun Xia (22173550)

    Published 2025
    “…In the hippocampus of GBP-treated mice, increased levels of p-tau (S416) and p-tau (S262) were observed, together with increased CaMKIIα and decreased Sirt1 expression. AAV-mediated Sirt1 overexpression in the hippocampus or systemic administration of the Sirt1 activator resveratrol prevented cognitive impairment and tau hyperphosphorylation via enhancing Sirt1 activity in GBP-treated mice.…”
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    Proposed mechanism of action of ibuprofen (IBU) on hypoxic cancer cells. by Katarina Grossmannova (7543517)

    Published 2025
    “…<p>IBU impairs the STAT3 pathway and downregulates HIF-1α protein leading to impaired HIF-1 binding on the <i>CA9</i> promoter. The disruption of CA IX transcription results in a decreased level of CA IX on cancer cell membrane. …”
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    Image 1_Differential Ca2+ handling by isolated synaptic and non-synaptic mitochondria: roles of Ca2+ buffering and efflux.tif by Jyotsna Mishra (3703195)

    Published 2025
    “…Synaptic mitochondria appear to rely mainly on mCa<sup>2+</sup> efflux via mNCE, while non-synaptic mitochondria rely mainly on P<sub>i</sub>-dependent mCa<sup>2+</sup> sequestration. …”