بدائل البحث:
values decrease » values increased (توسيع البحث), largest decrease (توسيع البحث)
parp decrease » a decrease (توسيع البحث), pa decreased (توسيع البحث), step decrease (توسيع البحث)
ct values » _ values (توسيع البحث), i values (توسيع البحث)
values decrease » values increased (توسيع البحث), largest decrease (توسيع البحث)
parp decrease » a decrease (توسيع البحث), pa decreased (توسيع البحث), step decrease (توسيع البحث)
ct values » _ values (توسيع البحث), i values (توسيع البحث)
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Inotodiol decreases clone formation in HCC cells.
منشور في 2025"…In addition, inotodiol showed to induce apoptosis, characterized by an increase in Bax expression, a decrease in Bcl-2, Bcl-XL and MCL1 expression, the initiation of cleaved PARP1 and cleaved caspase 3, and inhibition of the MAPK/ERK pathway. …"
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PARP9 knockdown promotes apoptosis and DNA damage.
منشور في 2024"…(E) DNA damage in GC cells significantly increased post-PARP9 knockdown as determined by comet assay. (F) The anti-DNA damage capacity of GC cells decreased markedly following reduction of PARP9 expression. …"
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Data Sheet 1_Imaging-based assessment of response to olaparib in platinum-sensitive relapsed ovarian cancer patients.pdf
منشور في 2025"…In this work, we developed noninvasive imagingbased measurements of spatial and longitudinal heterogeneity in a retrospective analysis of a phase 2 non-randomized study of germline BRCA1/BRCA2 mutated (gBRCAm) ovarian cancer patients treated with combination of PARP inhibitors (PARPi) and immune checkpoint inhibitors (ICIs).…"
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Table 1_PARP inhibition increases sensitivity to cisplatin in non-small-cell lung carcinoma via the induction of TET-dependent hydroxymethylation.xlsx
منشور في 2025"…Treatment of A549 cells with niraparib resulted in decreased PARP activity, increased 5hmC level, and synergism with cisplatin by promoting cisplatin-induced apoptosis. …"
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Data Sheet 1_PARP inhibition increases sensitivity to cisplatin in non-small-cell lung carcinoma via the induction of TET-dependent hydroxymethylation.pdf
منشور في 2025"…Treatment of A549 cells with niraparib resulted in decreased PARP activity, increased 5hmC level, and synergism with cisplatin by promoting cisplatin-induced apoptosis. …"
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Figure 3 from Synergistic Effects of PARP Inhibition and Cholesterol Biosynthesis Pathway Modulation
منشور في 2025"…<b>D,</b> Transcriptomic analysis of T47D cell line treated with niraparib or olaparib (10 μmol/L; 48 hours). Mean fold changes (<i>n</i> = 3) and adjusted <i>P</i> values from one representative experiment are shown. …"
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Effect of curcumin on methotrexate-induced ovarian damage and follicle reserve in rats: the role of PARP-1 and P53
منشور في 2024"…Expressions of p53 and Poly [ADP-ribose] polymerase 1 (PARP-1) increased significantly in the MTX group compared to the other groups (<i>p</i> < 0,05).…"
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Over expression of SOX6 attenuates apoptosis and DNA damage in AGS cells.
منشور في 2024"…(B) At the protein level, it was confirmed that SOX6 levels decreased concomitantly with diminishing PARP9 expression. …"
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Figure S1 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer
منشور في 2025"…Results are presented as mean ± SEM; * P < 0.05; two-way ANOVA.</p>…"
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