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Loss of virulence in the SIN kinase mutants is characterized by decreased fungal burden and host response to infection.
Published 2021“…Quantitation of IL-1β <b>(B)</b> and TNFα <b>(C)</b> revealed decreased host response in SIN kinase mutant infected mice. …”
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Decreased virulence observed during <i>in planta</i> infection with <i>ΔFgknr4</i>.
Published 2025“…Ab = abaxial wheat cell layer, ad = adaxial wheat cell layer, as = air spaces, and h = fungal hyphae. In wheat inoculated with <i>ΔFgknr4</i> compared to WT, decreased host colonisation is observed, evidenced by (i) reduced fungal hyphae proliferation, particularly in the thicker adaxial cell layer, (ii) collapsed air spaces in wheat cells, and (iii) increased polymer deposition at the wheat cell walls (black arrows), indicating an enhanced defence response. …”
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<i>FGR41</i> overexpression does not impact fungal burden 4 days post infection.
Published 2022Subjects: -
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Bendamustine treatment of haematological malignancies: significant risks of opportunistic viral, fungal and bacterial infections
Published 2022“…</p> <p>Our observations showed that even with a vigorous anti-infective strategy, bendamustine treatment was still associated with significant risks of bacterial and opportunistic viral and fungal infections.…”
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