Alpha lipoic acid attenuates ER stress and improves glucose uptake through DNAJB3 cochaperone حسب Abdoulaye Diane (14152749)

"…A similar increase in DNAJB3 mRNA was also observed in HepG2 cells. …"

Precision meets repurposing: Innovative approaches in human papillomavirus and Epstein-Barr virus-driven cancer therapy حسب Fernandes, Queenie

"…Therapeutic vaccines directed at such oncoviruses, often fail to unleash the desired immune response against the tumor. …"
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Reactions, Adsorption and Diffusion in FCC Catalysts حسب Mahaly, Wafa

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1787 evaluation of transperineal prostatic administration of a PSA-activasted protoxin (PRX302) in men with luts secondary to BPH حسب Elhilali, Mostafa

"…However, no clear dose response was observed and Qmax did not increase in this study. …"
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Dicarbonyl stress, protein glycation and the unfolded protein response حسب Naila Rabbani (291722)

"…An optimized inducer of Glo1 expression, trans-resveratrol and hesperetin combination, normalized increased MG concentration, corrected insulin resistance and decreased low grade inflammation in overweight and obese subjects. …"

Precision meets repurposing: Innovative approaches in human papillomavirus and Epstein-Barr virus-driven cancer therapy حسب Queenie Fernandes (14557388)

"…Therapeutic vaccines directed at such oncoviruses, often fail to unleash the desired immune response against the tumor. …"

Immune Checkpoints in Circulating and Tumor-Infiltrating CD4+ T Cell Subsets in Colorectal Cancer Patients حسب Salman M. Toor (8854751)

"…The tumor microenvironment (TME) is largely responsible for response to therapy, and its constituents may provide robust biomarkers for successful immunotherapeutic approaches. …"

Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator‐activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibrobl... حسب Faour, Wissam

"…Objective To characterize the inhibitory effects of therapeutic concentrations of the nonsteroidal antiinflammatory drug nimesulide (NIM) on peroxisome proliferator-activated receptor (PPAR)-induced cyclooxygenase 2 (COX-2) gene expression in human synovial fibroblasts (HSFs) from patients with osteoarthritis (OA) and to define the intracellular mechanisms mediating the response. …"
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Combinatory effect of diet and exercise on brain derived neurotrophic factor expression, cognitive function and behavioral phenotypes of psychiatric disorders. (c2017) حسب Abou Haidar, Edwina T.

"…BDNF levels are dramatically decreased in the adult brain in response to stress and are elevated by increased exercise. …"
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Part II.: Dissimilar friction stir welding of nickel titanium shape memory alloy to stainless steel – microstructure, mechanical and corrosion behavior حسب Parker West (17268946)

"…The decreased corrosion resistance was attributed to inhomogeneous passive film formed across the weld due to zonal heterogeneities. …"

Could the New BA.2.75 Sub-Variant Cause the Emergence of a Global Epidemic of COVID-19? A Scoping Review حسب Nour Shaheen (14034758)

"…A thorough assessment of control measures, as well as timely adjustment of control measures, requires addressing such issues as re-infection risk, vaccine response, booster vaccine doses, and the increased rate of Omicron infections. …"

Suicidal gene therapy in an NF-κB-controlled tumor environment as monitored by a secreted blood reporter حسب Zalloua, P. A.

"…We have cloned a novel NF-κB-based reporter system (five tandem repeats of NF-κB responsive genomic element (NF; 14 bp each)) to drive the expression cassette for both a fusion between the yeast cytosine deaminase and uracil phosphoribosyltransferase (CU) as a therapeutic gene and the secreted Gaussia luciferase (Gluc) as a blood reporter, separated by an internal ribosomal entry site (NF-CU-IGluc). …"
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Thermal challenges in lithium-ion battery technology: Investigating performance and thermal stability حسب Kenza Maher (22803425)

"…Elevated temperatures exacerbate internal resistance and accelerate chemical reactions within the battery, leading to heat generation, performance loss, and potential safety risks, including thermal runaway. …"

PD-L1 Blockade by Atezolizumab Downregulates Signaling Pathways Associated with Tumor Growth, Metastasis, and Hypoxia in Human Triple Negative Breast Cancer حسب Reem Saleh (3513056)

"…Using functional assays, we confirmed that atezolizumab increases MDA-MB-231 cell apoptosis/necrosis, and reduces their proliferation and viability. …"

DJ-1, a peten inhibitor, is a positive regulator of cancer cell motility. (c2014) حسب Yassine, Rawan M.

"…DJ-1 is a 20-KDa protein that was first identified as an oncogene product responsible for a subset of familial Parkinson’s disease; hence its name PARK 7. …"
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Oral Spirulina Platensis Attenuates Hyperglycemia and Exhibits Antinociceptive Effect in Streptozotocin-Induced Diabetic Neuropathy Rat Model حسب Mohamed M Abdel-Daim (20362725)

"…An exaggerated nociceptive response occurred in diabetic rats after the formalin test. …"

Uhrf1 regulates adipogenesis through GPNMB mediated TGFBeta axis حسب Muneera Vakayil (12037693)

"…Therefore, understanding the cellular mechanisms responsible for adipogenesis, the conversion of preadipocytes to adipocytes, is critical for identifying anti-diabetic therapeutic targets. …"

Inflammatory protein signatures in individuals with obesity and metabolic syndrome حسب Fayaz Ahmad Mir (11828354)

"…This provides valuable insights into some of the underlying mechanisms and can lead to identification of therapeutic targets to improve metabolic health in individuals with obesity.…"

Treatment with decitabine induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer: potential for combined chemoimmunotherapy حسب Nassiba Taib (14557385)

"…In addition, induction of NY-ESO-1 may represent an immuno-therapeutic option in metastatic CRC patients. Finally, the combination of DAC and anti-PD-1/anti-PD-L1 antibodies treatment should represent a potential therapeutic intervention for this group of patients.…"

3D Tissue-Engineered Vascular Drug Screening Platforms: Promise and Considerations حسب Isra Marei (11312895)

"…Besides factors such as the increased cost of clinical trials and increases in the requirements and the complexity of the regulatory processes, there is also a gap between the currently existing pre-clinical screening methods and the clinical studies in humans. …"