Showing 61 - 80 results of 2,307 for search '(( decrease host resistance ) OR ( ((decrease therapeutic) OR (degrader therapeutics)) options ))', query time: 0.57s Refine Results
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    DataSheet1_Dual Blockade of Misfolded Alpha-Sarcoglycan Degradation by Bortezomib and Givinostat Combination.pdf by Lucile Hoch (12465816)

    Published 2022
    “…Functional characterization revealed that givinostat effect was related to autophagic pathway inhibition, unveiling new theories concerning degradation pathways of misfolded SG proteins. Beyond the identification of a new therapeutic option for LGMD R3 patients, our results shed light on the potential repurposing of givinostat for the treatment of other genetic diseases sharing similar protein degradation defects such as LGMD R5 and cystic fibrosis.…”
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    DataSheet2_Dual Blockade of Misfolded Alpha-Sarcoglycan Degradation by Bortezomib and Givinostat Combination.pdf by Lucile Hoch (12465816)

    Published 2022
    “…Functional characterization revealed that givinostat effect was related to autophagic pathway inhibition, unveiling new theories concerning degradation pathways of misfolded SG proteins. Beyond the identification of a new therapeutic option for LGMD R3 patients, our results shed light on the potential repurposing of givinostat for the treatment of other genetic diseases sharing similar protein degradation defects such as LGMD R5 and cystic fibrosis.…”
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    Food supplementation affects gut microbiota and immunological resistance to parasites in a wild bird species by Sarah Knutie (3609899)

    Published 2019
    “…Furthermore, supplemental feeding could induce resistance to detrimental parasites (e.g. invasive parasites) in hosts when management of the parasite is not immediately possible. …”
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    CDK4/6 inhibition presents as a therapeutic option for pediatric and adult germ cell tumors and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms by Margaretha Skowron (3449309)

    Published 2020
    “…</p><p><b>Conclusion:</b> Our study highlights PaRi as therapeutic options for cisplatin-resistant and -sensitive pediatric and adult GCTs. …”
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    Data_Sheet_2_The Effect of Host Immunity on Predicting the Mortality of Carbapenem-Resistant Organism Infection.docx by Qun Lin (808443)

    Published 2020
    “…<p>Carbapenem-resistant organisms (CROs) are associated with considerable mortality clinically. …”
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    Data_Sheet_1_The Effect of Host Immunity on Predicting the Mortality of Carbapenem-Resistant Organism Infection.PDF by Qun Lin (808443)

    Published 2020
    “…<p>Carbapenem-resistant organisms (CROs) are associated with considerable mortality clinically. …”
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