The picture represents experimental design for the chronic study according to the groups and their treatment regime. by Sinthia Kabir Mumu (17705902)

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Fig 4 - by Sinthia Kabir Mumu (17705902)

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Discovery of Oral Degraders of the ROS1 Fusion Protein with Potent Activity against Secondary Resistance Mutations by Xianyou Peng (2130313)

“…More importantly, the degradation-based therapeutic modality can overcome on-target mutation resistance to tyrosine kinase inhibitors by efficient degradation of the mutated kinase to achieve greater potency than inhibition.…”

MNGC formation is lower in 1α,25(OH)₂D₃-pretreated A549 cells during <i>B</i>. <i>pseudomallei</i> infection. by Pohnratchada Mattrasongkram (14593528)

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Confirmation of MNGC reduction in 1α,25(OH)₂D₃-pretreated A549 cells during <i>B</i>. <i>pseudomallei</i> infection. by Pohnratchada Mattrasongkram (14593528)

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Effect of pretreatment of A549 cells with 1α,25(OH)₂D₃ on aspects of <i>B</i>. <i>pseudomallei</i> infection. by Pohnratchada Mattrasongkram (14593528)

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Expression of hCAP-18/LL-37 mRNA in 1α,25(OH)₂D₃-pretreated A549 cells. by Pohnratchada Mattrasongkram (14593528)

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Cytokine expression during <i>B</i>. <i>pseudomallei</i> infection. by Pohnratchada Mattrasongkram (14593528)

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Effect of 1α,25(OH)₂D₃ on the survival of A549 cells and <i>B</i>. <i>pseudomallei</i> H777. by Pohnratchada Mattrasongkram (14593528)

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Effect of 1α,25(OH)₂D₃ pretreatment of A549 cells on <i>B</i>. <i>pseudomallei</i> multiplication. by Pohnratchada Mattrasongkram (14593528)

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Intraperitoneal administration with streptavidin benefits an establishment of a CD-1 mice model for <i>P</i>. <i>aeruginosa</i>, of which the plasma (and organ contents) biotin lev... by Yu Shi (117923)

Establishment of cyprodinil resistance (CypR) as a novel selection marker for <i>B</i>. <i>cinerea</i>. by Thomas Leisen (9248883)

Development of Oral, Potent, and Selective CK1α Degraders for AML Therapy by Lu Huang (211625)

“…These findings indicate that phenotypic drug discovery campaigns, in combination with chemically distinct CRBN ligand libraries, can accelerate the development of therapeutically relevant MGDs. Furthermore, the development of dCK1α-1 and dCK1α-2 provides new therapeutic options for cancers with functional p53 signaling and offers valuable chemical tools for future investigations into the role of CK1α.…”

Development of Oral, Potent, and Selective CK1α Degraders for AML Therapy by Lu Huang (211625)

“…These findings indicate that phenotypic drug discovery campaigns, in combination with chemically distinct CRBN ligand libraries, can accelerate the development of therapeutically relevant MGDs. Furthermore, the development of dCK1α-1 and dCK1α-2 provides new therapeutic options for cancers with functional p53 signaling and offers valuable chemical tools for future investigations into the role of CK1α.…”

Development of Oral, Potent, and Selective CK1α Degraders for AML Therapy by Lu Huang (211625)

“…These findings indicate that phenotypic drug discovery campaigns, in combination with chemically distinct CRBN ligand libraries, can accelerate the development of therapeutically relevant MGDs. Furthermore, the development of dCK1α-1 and dCK1α-2 provides new therapeutic options for cancers with functional p53 signaling and offers valuable chemical tools for future investigations into the role of CK1α.…”

<i>In vivo</i> silencing (RNAi) of pairing-dependent lincRNAs decreases the number of <i>S</i>. <i>mansoni</i> adult worms recovered from infected mice. by Gilbert O. Silveira (7376819)

UBKIs possess broad antiviral activity, are effective in primary cells, and impose a barrier against resistance development. by Markus Lesch (6475409)

Volcano plot analysis of differential expression lncRNAs between F18-resistant and -sensitive piglets. by Zhengchang Wu (140532)

Volcano plot analysis of differential expression mRNAs between F18-resistant and -sensitive piglets. by Zhengchang Wu (140532)

DataSheet_1_NtrBC Selectively Regulates Host-Pathogen Interactions, Virulence, and Ciprofloxacin Susceptibility of Pseudomonas aeruginosa.docx by Morgan A. Alford (8799320)

“…Here, we demonstrated that NtrBC, the master of nitrogen control, had a selective role in host colonization and a substantial role in determining intrinsic resistance to ciprofloxacin. …”