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Reversal of Insulin Resistance in Overweight and Obese Subjects by trans-Resveratrol and Hesperetin Combination—Link to Dysglycemia, Blood Pressure, Dyslipidemia, and Low-Grade Inf...
Published 2021“…These correlations were not present with placebo. tRES-HESP decreased low-grade inflammation, characterized by decreased expression of CCL2, COX-2, IL-8, and RAGE. …”
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Differences in protein expression, at the basal state and at 2 h of insulin infusion, in muscle biopsies from healthy Arab men with high or low insulin sensitivity measured by hype...
Published 2023“…Additionally, we show differences in protein levels from skeletal muscle in low and high insulin sensitivity groups. Therefore, these differences may represent early events for the development of insulin resistance, pre-diabetes, and type 2 diabetes.…”
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Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer
Published 2020“…In addition, there are increasing concerns about drug resistance. In the continuous search for safer and more effective treatments, plant-derived natural compounds are of major interest. …”
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TRPV2: A Cancer Biomarker and Potential Therapeutic Target
Published 2020“…In prostate cancer, TRPV2 overexpression was associated with the castration-resistant phenotype and metastasis. Loss or inactivation of TRPV2 promoted glioblastoma cell proliferation and increased resistance to CD95-induced apoptotic cell death. …”
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Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications
Published 2022“…<p dir="ltr">The global burden of breast cancer (BC) is increasing significantly. This trend is caused by several factors such as late diagnosis, limited treatment options for certain BC subtypes, drug resistance which all lead to poor clinical outcomes. …”
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P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis
Published 2010“…We observed an increased P-gp expression (1.5-fold) in presymptomatic mSOD1 mice compared to wild-type controls. …”
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Prophylactic and therapeutic antibiotic patterns of lebanese dentists for the management of dentoalveolar abscesses
Published 2016“…The main prescribed antibiotic was amoxicillin.This study showed that dentists often did not follow the current prophylactic and therapeutic antibiotic prescription guidelines.Antibiotics prescriptions in dentistry will be more pertinent, leading to a decrease in inadequacy of prescriptions, microbial resistance, and the development of multiresistant germs against antibiotics…”
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Emerging Glycation-Based Therapeutics—Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors
Published 2022“…<div><p>The abnormal accumulation of methylglyoxal (MG) leading to increased glycation of protein and DNA has emerged as an important metabolic stress, dicarbonyl stress, linked to aging, and disease. …”
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Strategies for the production of long-acting therapeutics and efficient drug delivery for cancer treatment
Published 2019“…These two techniques improve stability, reduce immunogenicity, and increase drug resistance to proteases. These factors lead to the reduction of injection frequency which increases patient compliance and improve quality of life. …”
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FoxP3<sup>+</sup> T regulatory cells in cancer: Prognostic biomarkers and therapeutic targets
Published 2020“…We also describe potential therapeutic strategies to target Tregs in combination with other types of immunotherapies aiming to overcome tumor resistance and improve clinical outcomes in cancer patients. …”
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The changing landscape in the treatment of metastatic castration-resistant prostate cancer
Published 2012“…The past few years have brought increasing advances in the therapeutic management of metastatic castration-resistant prostate cancer with the approval of several agents, including vaccine therapy with sipuleucel-T, second-line chemotherapy with cabazitaxel, the bone-targeted pharmaceutical denosumab, and the novel antiandrogen therapy abiraterone acetate. …”
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Glycation in Alzheimer’s Disease and Type 2 Diabetes: The Prospect of Dual Drug Approaches for Therapeutic Interventions
Published 2025“…<p dir="ltr">As global life expectancy increases, the prevalence of neurodegenerative diseases like Alzheimer’s disease (AD) continues to rise. …”
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Metabolic signature of obesity-associated insulin resistance and type 2 diabetes
Published 2019“…</p><h3>Conclusion</h3><p dir="ltr">This pilot data has identified phospholipid metabolites as potential novel biomarkers of obesity-associated insulin sensitivity and confirmed the association of known metabolites with increased risk of obesity-associated insulin resistance, with possible diagnostic and therapeutic applications. …”
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Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes
Published 2023“…<p dir="ltr">Several pathways and/or genes have been shown to be dysregulated in obesity-induced insulin resistance (IR) and type 2 diabetes (T2D). We previously showed, for the first time, impaired expression of DNAJB3 mRNA and protein in subjects with obesity, which was concomitant with increased metabolic stress. …”
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Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy
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Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance
Published 2024“…This diversity, known as cancer cell plasticity, confers cancer cells the ability to change in response to their environment, leading to increased tumor diversity and drug resistance. This review explores the intricate landscape of cancer cell plasticity, offering a deep dive into the cellular, molecular, and genetic mechanisms that underlie this phenomenon. …”
