Uhrf1 regulates adipogenesis through GPNMB mediated TGFBeta axis حسب Muneera Vakayil (12037693)

"…Therefore, understanding the cellular mechanisms responsible for adipogenesis, the conversion of preadipocytes to adipocytes, is critical for identifying anti-diabetic therapeutic targets. …"

Inflammatory protein signatures in individuals with obesity and metabolic syndrome حسب Fayaz Ahmad Mir (11828354)

"…This provides valuable insights into some of the underlying mechanisms and can lead to identification of therapeutic targets to improve metabolic health in individuals with obesity.…"

Treatment with decitabine induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer: potential for combined chemoimmunotherapy حسب Nassiba Taib (14557385)

"…In addition, induction of NY-ESO-1 may represent an immuno-therapeutic option in metastatic CRC patients. Finally, the combination of DAC and anti-PD-1/anti-PD-L1 antibodies treatment should represent a potential therapeutic intervention for this group of patients.…"

3D Tissue-Engineered Vascular Drug Screening Platforms: Promise and Considerations حسب Isra Marei (11312895)

"…Besides factors such as the increased cost of clinical trials and increases in the requirements and the complexity of the regulatory processes, there is also a gap between the currently existing pre-clinical screening methods and the clinical studies in humans. …"

Elucidating the Probiotic Potential of <i>Lactobacillus</i> and <i>Bifidobacterium</i> Species in Modulating Glucose Metabolism and Inflammation in Gestational Diabetes Mellitus: A... حسب Sidra A Uzair (23124226)

"…The evidence indicates the potential of <i>Lactobacillus</i>- and <i>Bifidobacterium</i>-based probiotic interventions to beneficially influence glucose metabolism, inflammatory response, and gut microbial balance in GDM. Heterogeneity in probiotic formulations across studies, probiotic doses, and regional differences in diet and lifestyle underscore the need for more targeted and standardized research to fully understand the therapeutic potential of probiotics in GDM.…"

Extramedullary haematopoiesis in patients with transfusion dependent β-thalassaemia (TDT): a systematic review حسب Eihab A. Subahi (12217761)

"…However, there are increasingly reported cases of EMH in BTM. The incidence of EMH in BTM is thought to be <1%. …"

Deciphering the In vitro Role of microRNAs miR-21-3p and miR-222-5p In the Regulation of Clostridioides difficile Flagellin-Induced Inflammation حسب Salman, Zeina

"…These findings underscore the roles of miR-222-5p and miR-21-3p as potential regulators of FliC-induced inflammation and provide insight into the molecular mechanisms underlying C. difficile-associated inflammatory responses. Future studies could explore their therapeutic potential in mitigating intestinal inflammation in vivo in mouse model of C. difficile infections.…"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Immunomodulatory effects of tumor Lactate Dehydrogenase C (LDHC) in breast cancer حسب Adviti Naik (673163)

"…</p><h3>Conclusions</h3><p dir="ltr">Our findings suggest that targeting LDHC could enhance anti-tumor immune responses by modulating cytokine and chemokine secretion in addition to impairing immune checkpoint signaling. …"

The Kinetics of Calcein Release from Mixed Targeted Liposomes Using Ultrasound حسب AlSawaftah, Nour Majdi

"…Site-specific delivery of chemotherapeutics using actively targeted-stimuli-responsive liposomes is a promising approach to enhance the therapeutic efficiency of anti-cancer drugs while reducing the associated undesirable side effects. …"
احصل على النص الكامل

Role of cytokines and platelet-activating factor in inflammatory bowel disease حسب Nassif, Anis

"…Cytokines are peptides that regulate and coordinate inflammatory and immunologic responses. Increased production of cytokines has been reported during Crohn's disease and ulcerative colitis and is correlated with disease activity. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Noncoding RNAs in Nonalcoholic Fatty Liver Disease: Potential Diagnosis and Prognosis Biomarkers حسب Olfa Khalifa (10914452)

"…<p>Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease worldwide in part due to the concomitant obesity pandemic and insulin resistance (IR). It is increasingly becoming evident that NAFLD is a disease affecting numerous extrahepatic vital organs and regulatory pathways. …"

Synergistic Effects of Nanomedicine Targeting TNFR2 and DNA Demethylation Inhibitor—An Opportunity for Cancer Treatment حسب Mohammad A. I. Al-Hatamleh (11564929)

"…From an epigenetic perspective, previous studies indicate that DNA demethylation might be responsible for high expressions of TNFR2 in cancer models. …"

Arsenic: A double-edged sword حسب Nature Research (16552612)

"…Research shows that As₂O₃increases intracellular calcium ion concentration irreversibly. …"

Profiling the autoantibody repertoire reveals autoantibodies associated with mild cognitive impairment and dementia حسب Hanan Ehtewish (17149825)

"…And 20 proteins had significantly altered autoantibody responses in MCI compared to cognitively normal individuals. …"

Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance حسب Gh Rasool Bhat (13038132)

"…This diversity, known as cancer cell plasticity, confers cancer cells the ability to change in response to their environment, leading to increased tumor diversity and drug resistance. …"

Metal-based nanoparticles: Promising tools for the management of cardiovascular diseases حسب Nour K., Younis

"…A search for more effective treatments of CVD is increasingly needed. Major advances in nanotechnology opened new avenues in CVD therapeutics. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Metal-based nanoparticles: Promising tools for the management of cardiovascular diseases حسب Nour K. Younis (14152512)

"…A search for more effective treatments of CVD is increasingly needed. Major advances in nanotechnology opened new avenues in CVD therapeutics. …"

SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways حسب Yasser Majeed (9417974)

"…Supplementing preadipocytes with the NAD+ booster nicotinamide mononucleotide (NMN) during differentiation increased expression levels of leptin, SIRT1, and PGC-1α and its transcriptional targets, and reduced levels of pro-fibrotic collagens (Col6A1 and Col6A3) in a SIRT1-dependent manner. …"