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Characterizing the Effect of Arginine Deprivation on Autophagic Response in Breast Cancer cells
Published 2021“…Residual ASS1 tumor expression corelated with increased metastasis and decreased survival in patient luminal A, Her2+ and triple-negative breast cancer. …”
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2
Investigating the Therapeutic Effects of Small Molecule Imipridones In Pediatric Neuroblastoma
Published 2020“…Our findings demonstrate an important multi-target effect of imipridones that may yield added therapeutic benefits in treating this devastating cancer.…”
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3
Optimizing clopidogrel dose response
Published 2016“…Results The study results show that all patients under clopidogrel treatment, whose genotypes are different from *1*1, and concomitantly taking other drugs metabolized by CYP2C19 require clopidogrel dose adjustment. To get a therapeutic effect and avoid adverse drug reactions, therapeutic dose of 75 mg clopidogrel, for example, should be lowered to 6 mg or increased to 215 mg in patients with different genotypes. …”
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Skin responses to fractional photothermolysis
Published 2006“…Background and Objective Fractional photothermolysis (FP) is a new concept using arrays of microscopic thermal damage patterns to stimulate a therapeutic response. We analyzed epidermal and dermal response to FP with the aim of correlating histological and clinical response. …”
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P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis
Published 2010“…The lack of response to treatment in ALS may be, at least in part, due to increased activities of efflux pumps in relation to disease, leading to subtherapeutic brain concentrations of drugs. …”
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Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications
Published 2020“…Dysbiotic microbiota may lead to a dysregulated immune response that may contribute to the pathogenesis of coeliac disease. …”
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Emerging Glycation-Based Therapeutics—Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors
Published 2022“…Increased MG glycation produces inactivation and misfolding of proteins, cell dysfunction, activation of the unfolded protein response, and related low-grade inflammation. …”
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Decoding the Therapeutic Potential of [HuArgI (Co)-PEG5000] Arginase Treatment
Published 2023“…Moreover, our study results lay the groundwork for the creation of innovative combination treatments that specifically target different facets of cancer cell behavior, offering patients with breast cancer better prognoses and increased therapeutic efficacy.…”
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masterThesis -
9
FoxP3<sup>+</sup> T regulatory cells in cancer: Prognostic biomarkers and therapeutic targets
Published 2020“…They maintain immune homeostasis and inhibit immune responses in various diseases, including cancer. Proportions of Tregs in the peripheral blood of some cancer patients increase by approximately two-fold, compared to those in healthy individuals. …”
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Ultrasound-responsive Nanocarriers in Cancer Treatment: a review
Published 2021“…Using smart nanocarriers, the rate of release of the entrapped therapeutic(s) can be increased, and greater exposure of the tumor cells to the therapeutics can be achieved when the nanocarriers are exposed to certain internally (enzymes, pH and temperature) or externally applied (light, magnetic field, and ultrasound) stimuli that trigger the release of their load in a safe and controlled manner, spatially and temporally. …”
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Recombinant Adeno-Associated Virus-Mediated In Utero Gene Transfer Gives Therapeutic Transgene Expression in the Sheep
Published 2011“…This is the first study to show therapeutic long-term hFIX transgene expression after in utero gene transfer in a large animal model.…”
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Chronic reduction of store operated Ca<sup>2+</sup> entry is viable therapeutically but is associated with cardiovascular complications
Published 2022“…Given its central role in immune cell activation, SOCE has been a therapeutic target for autoimmune and inflammatory diseases. …”
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Acoustically activated release of estrone-targeted liposomes used for breast cancer treatment
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doctoralThesis -
15
Microbial Dysbiosis Tunes the Immune Response Towards Allergic Disease Outcomes
Published 2022“…<p>The hygiene hypothesis has been popularized as an explanation for the rapid increase in allergic disease observed over the past 50 years. …”
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Editorial: Dynamic Biomarkers of Response to Anti-Immune Checkpoint Inhibitors in Cancer
Published 2021“…One promising emerging approach is to focus on dynamic biomarkers, which would allow, when tested in the patient early after exposition to the therapeutic agents, to identify those patients presenting an immune response failure. …”
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Potential mechanisms of human recombinant arginase I (Co)-PEG5000 [HuArgI (CO) - PRG5000] induced cytotoxicity in glioblastoma cells. (c2018)
Published 2018“…Hence, HuArgI (Co)-PEG5000 is an efficient and selective therapeutic method for targeting GBM.…”
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masterThesis -
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Targeting arginine auxotrophy in pancreatic cancer cells using human recombinant arginase I-induced arginine deprivation. (c2017)
Published 2017“…Therefore, there’s a need for more effective and selective therapeutic approaches for targeting PC. In this study, we examined the mechanisms of arginine auxotrophy in PC cell lines. …”
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masterThesis -
19
Metformin Induces Different Responses in Clear Cell Renal Cell Carcinoma Caki Cell Lines
Published 2019“…Our study unveils the therapeutic potential of metformin to inhibit the progression of ccRCC in vitro. …”
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Unleashing the immune response to NY-ESO-1 cancer testis antigen as a potential target for cancer immunotherapy
Published 2022“…We propose that combination therapy to increase the efficacy of NY-ESO-1 specific immunotherapeutic interventions should be explored to unleash the immune response against NY-ESO-1 expressing tumors.…”
