iPSCs derived from insulin resistant offspring of type 2 diabetic patients show increased oxidative stress and lactate secretion by Bushra Memon (4792767)

“…IR-iPSCs have increased cellular oxidative stress indicated by a high production of reactive oxygen species and higher susceptibility to H2O2 -induced apoptosis.…”

Deletion of the Candida albicans PIR32 Results in Increased Virulence, Stress Response, and Upregulation of Cell Wall Chitin Deposition by Bahnan, Wael

“…The purpose of this study is to characterize Pir32 by generating a homozygous null strain and comparing the phenotype of the null with that of the wild-type parental strain as far as filamentation, virulence in a mouse model of disseminated candidiasis, resistance to oxidative stress and cell wall disrupting agents, in addition to adhesion, biofilm capacities, and cell wall chitin content. …”
Get full text
Get full text
Get full text

DNAJB3 attenuates ER stress through direct interaction with AKT by Zeyaul Islam (5867387)

“…This down regulation of HSPs is associated with insulin resistance (IR) and interventions which induce the heat shock response (HSR) help to increase the insulin sensitivity. …”

Alpha lipoic acid attenuates ER stress and improves glucose uptake through DNAJB3 cochaperone by Abdoulaye Diane (14152749)

“…<p dir="ltr">Persistent ER stress, mitochondrial dysfunction and failure of the heat shock response (HSR) are fundamental hallmarks of insulin resistance (IR); one of the early core metabolic aberrations that leads to type 2 diabetes (T2D). …”

Dicarbonyl stress, protein glycation and the unfolded protein response by Naila Rabbani (291722)

“…<p>The reactive dicarbonyl metabolite, methylglyoxal (MG), is increased in obesity and diabetes and is implicated in the development of insulin resistance, type 2 diabetes mellitus and vascular complications of diabetes. …”

Alleviation of drought and salt stress in vegetables: crop responses and mitigation strategies by Muhammad Fasih Khalid (10652246)

“…Climate change has affected vegetable production by increasing the frequencies and severity of abiotic and biotic stresses. …”

Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes by Shadi Nejat (19457212)

“…<p dir="ltr">Several pathways and/or genes have been shown to be dysregulated in obesity-induced insulin resistance (IR) and type 2 diabetes (T2D). We previously showed, for the first time, impaired expression of DNAJB3 mRNA and protein in subjects with obesity, which was concomitant with increased metabolic stress. …”

Proteomic Characterization Of Clinical Candida glabrata Isolates With Varying Degrees Of Virulence And Resistance To Fluconazole by Zeidan, Ahmad

“…Azoles work by inhibiting the Erg11 enzyme altering the conversion of lanosterol to ergosterol, the main sterol found in fungi. Resistance to azoles is increasing among Candida species worldwide, and in Lebanon. …”
Get full text
Get full text
Get full text

Biochemical Characterization of Halotolerant Bacillus safensis PM22 and Its Potential to Enhance Growth of Maize under Salinity Stress by Muhammad Atif Azeem (17542080)

“…Additionally, inoculation of the halotolerant bacteria PM22 reduced the severity of salinity stress in plants and increased root and shoot length at various salt concentrations (0, 180, 240, and 300 mM). …”

Hexokinase-2-Linked Glycolytic Overload and Unscheduled Glycolysis—Driver of Insulin Resistance and Development of Vascular Complications of Diabetes by Naila Rabbani (291722)

“…<div><p>The recent discovery of the glucose-induced stabilization of hexokinase-2 (HK2) to proteolysis in cell dysfunction in model hyperglycemia has revealed a likely key initiating factor contributing to the development of insulin resistance and vascular complications in diabetes. Consequently, the increased flux of glucose metabolism without a change in the expression and activity of glycolytic enzymes produces a wave of increased glycolytic intermediates driving mitochondrial dysfunction and increased reactive oxygen species (ROS) formation, the activation of hexosamine and protein kinase C pathways, the increased formation of methylglyoxal-producing dicarbonyl stress, and the activation of the unfolded protein response. …”

Hexokinase-linked glycolytic overload and unscheduled glycolysis in hyperglycemia-induced pathogenesis of insulin resistance, beta-cell glucotoxicity, and diabetic vascular complic... by Naila Rabbani (291722)

“…Downstream effector pathways of HK-linked unscheduled glycolysis are mitochondrial dysfunction and increased reactive oxygen species (ROS) formation; activation of hexosamine, protein kinase c, and dicarbonyl stress pathways; and increased Mlx/Mondo A signaling. …”

Soil Characterization Utilizing GPR Technique by Al Kej, Fateh Tamam

Get full text

Immunohistochemical profiling of the heat shock response in obese non-diabetic subjects revealed impaired expression of heat shock proteins in the adipose tissue by Ali Tiss (437068)

“…<p dir="ltr">Obesity is characterized by a chronic low-grade inflammation and altered stress responses in key metabolic tissues. Impairment of heat shock response (HSR) has been already linked to diabetes and insulin resistance as reflected by decrease in heat shock proteins (HSPs) expression. …”

Emerging Glycation-Based Therapeutics—Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors by Naila Rabbani (291722)

“…<div><p>The abnormal accumulation of methylglyoxal (MG) leading to increased glycation of protein and DNA has emerged as an important metabolic stress, dicarbonyl stress, linked to aging, and disease. …”

Multi-Objective Optimisation of Injection Moulding Process for Dashboard Using Genetic Algorithm and Type-2 Fuzzy Neural Network by Mohammad Reza Chalak Qazani (13893261)

“…Its purpose was to estimate shear and residual stress levels. Additionally, the multi-objective genetic algorithm (MOGA) was utilised to extract the most optimal parameters for the injection moulding process, aiming to minimise shear and residual stress and thereby increase the resistance of the final product. …”

Effect of Bentonite Permeation on the Fabric and Strength of Ottawa Sand by Mourtada, Dani Imad

“…However, resonant column tests on bentonite-treated dry mixed Ottawa Sand samples showed a decrease of the small strain stiffness modulus (Gmax) and thus a decrease in the shear strength of the treated soil compared to that of clean Ottawa Sand samples. …”
Get full text
Get full text
Get full text

Proteomic analyses of the cell walls of candida albicans PGA1 and PIR32 null mutants. (c2017) by Khoury, Pamela Milad El

“…The pga1 null strain was less adherent and virulent than the wild type strain and exhibited reductions in chitin deposition, biofilm formation, filamentation, and resistance to stress. The pir32 null strain on the other hand showed more pronounced phenotypes such as hyperfilamentation ability, and increased resistance to oxidative stress in part due to a two fold increase in chitin deposition. …”
Get full text
Get full text
Get full text

Dextran Sodium Sulfate-Induced Impairment of Protein Trafficking and Alterations in Membrane Composition in Intestinal Caco-2 Cell Line by Toutounji, Mohamad

“…DSS treatment significantly reduced the transepithelial electric resistance (TEER) and increased the epithelial permeability of Caco-2 cells, without affecting their viability. …”
Get full text
Get full text
Get full text
Get full text

3D Printable Ca(OH)₂-based geopolymer concrete with steel fiber reinforcement by Youssef Mortada (16810656)

“…Microstructural analysis using scanning electron microscopy (SEM) and X-ray micro-computed tomography (µCT) demonstrated the crack-bridging behavior of steel fibers, enhancing ductility and fracture resistance. There was a slight increase in porosity (5.34%) of SF-reinforced samples without negatively affecting their mechanical properties. …”

Comparative proteomic analysis of a Candida albicans DSE1 mutant under filamentous and non-filamentous conditions by Khalaf, Roy A.

“…The wild-type strain expressed Pra1, involved in pH response and zinc acquisition, Atg15, a lipase involved in virulence, and Sod1, required for oxidative stress tolerance, in addition to proteins involved in protein biosynthesis, explaining the increase in total protein content observed compared to the mutants strain. …”
Get full text
Get full text
Get full text