Investigating The Efficacy of Ruxolitinib and CHIR-99021 in Targeting Pediatric Neuroblastoma Stem Cells حسب Al Sayyed, Fatima

"…CSCs play a crucial role in dysregulating different pathways that are involved in metastasis, invasion, angiogenic properties, uncontrolled proliferation, self-renewal capacities and therapeutic resistance. In this study, we investigate the efficacy of two small molecules Ruxolitinib, a JAK/STAT inhibitor, and CHIR-99021, a GSK-3 inhibitor, in targeting pediatric neuroblastoma stem cells by testing them on human MYC-N amplified, IMR-32, and non-MYC-N amplified, SK-N-SH, cell lines. …"
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Hexokinase-linked glycolytic overload and unscheduled glycolysis in hyperglycemia-induced pathogenesis of insulin resistance, beta-cell glucotoxicity, and diabetic vascular complic... حسب Naila Rabbani (291722)

"…Correction of HK2 dysregulation is proposed as a novel therapeutic target. Pharmacotherapy addressing it corrected insulin resistance in overweight and obese subjects in clinical trial. …"

Methionine mediates resilience to chronic social defeat by modulating NMDA receptor expression in the cortex. (c2018) حسب Bilen, Maria

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Novel Platinum II and Platinum IV Complexes Exhibit An Anti-Neoplastic Potential Against A549 Cancer Cell Line حسب Baz, Joy

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Immunoprofile of childhood diabetes حسب Meritxell Espino-Guarch (15430868)

"…When transcriptomic data was interrogated, an imbalance between ITGA4/ ITGB1 was observed in all groups where CD49d showed increased expression. Associated with these findings, anti-inflammatory Treg cytokines including IL-10 were decreased in T2D patients and elevated plasma levels of IL-17, which contributes to the insulin resistance and inflammation were observed.…"

Soil Characterization Utilizing GPR Technique حسب Al Kej, Fateh Tamam

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The role of dietary antioxidants in type 2 diabetes and neurodegenerative disorders: An assessment of the benefit profile حسب Munazza Tamkeen Fatima (17316955)

Inflammatory protein signatures in individuals with obesity and metabolic syndrome حسب Fayaz Ahmad Mir (11828354)

"…<p dir="ltr">There is variability in the metabolic health status among individuals presenting with obesity; some may be metabolically healthy, while others may have developed the metabolic syndrome, a cluster including insulin resistance, hypertension, dyslipidemia, and increased risk of cardiovascular disease and type 2 diabetes. …"

DNAJB3/HSP-40 cochaperone improves insulin signaling and enhances glucose uptake in vitro through JNK repression حسب Mohamed Abu-Farha (25322)

"…In summary, our results shed the light on the possible role of DNAJB3 in improving insulin sensitivity and glucose uptake through JNK repression and suggest that DNAJB3 could be a potential target for therapeutic treatment of obesity-induced insulin resistance.…"

Alpha lipoic acid attenuates ER stress and improves glucose uptake through DNAJB3 cochaperone حسب Abdoulaye Diane (14152749)

"…A similar increase in DNAJB3 mRNA was also observed in HepG2 cells. …"

Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes حسب Shadi Nejat (19457212)

"…<p dir="ltr">Several pathways and/or genes have been shown to be dysregulated in obesity-induced insulin resistance (IR) and type 2 diabetes (T2D). We previously showed, for the first time, impaired expression of DNAJB3 mRNA and protein in subjects with obesity, which was concomitant with increased metabolic stress. …"

Effect of Bentonite Permeation on the Fabric and Strength of Ottawa Sand حسب Mourtada, Dani Imad

"…However, resonant column tests on bentonite-treated dry mixed Ottawa Sand samples showed a decrease of the small strain stiffness modulus (Gmax) and thus a decrease in the shear strength of the treated soil compared to that of clean Ottawa Sand samples. …"
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The Human Microbiome in Chronic Kidney Disease: A Double-Edged Sword حسب Eman Wehedy (13275305)

"…Fluctuations in the urinary microbiome are linked to increased susceptibility to infection and antibiotic resistance. …"

Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia حسب Shilpa Kuttikrishnan (3520079)

"…Although chemotherapeutic approaches have been achieving successful remission for the majority of cases of childhood ALL, development of resistance to chemotherapy has been observed. Thus, new therapeutic approaches are required to improve patient's prognosis. …"

Natural products as chemo-radiation therapy sensitizers in cancers حسب Sabah Nisar (12561961)

"…While many recent studies have identified the underlying molecular mechanisms and therapeutic targets for CRT failure, using small molecule inhibitors to chemo/radio sensitize tumors is associated with high toxicity and increased morbidity. …"

Uhrf1 regulates adipogenesis through GPNMB mediated TGFBeta axis حسب Muneera Vakayil (12037693)

"…Obesity-linked inflammation is the major cause of insulin resistance, contributing to the onset of T2D. Therefore, understanding the cellular mechanisms responsible for adipogenesis, the conversion of preadipocytes to adipocytes, is critical for identifying anti-diabetic therapeutic targets. …"

Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway حسب Kirti.S. Prabhu (17191231)

"…<p dir="ltr">Effective treatment of lung cancer remains a significant clinical challenge due to its multidrug resistance and side effects of the current treatment options. …"

Cytokine-Mediated Dysregulation of Signaling Pathways in the Pathogenesis of Multiple Myeloma حسب Sabah Akhtar (5809925)

"…Besides, these pathways also participate in developing resistance against the chemotherapeutic drugs in MM. …"

Efficient and cost-effective alternative treatment for recurrent urinary tract infections and interstitial cystitis in women حسب Mansour, Anthony

"…We encountered two cases of recurrent UTIs (rUTIs) with a positive E. coli culture, not improving with antibiotics due to the development of antibiotic resistance. An alternative therapeutic regimen based on parsley and garlic, L-arginine, probiotics, and cranberry tablets has been given. …"
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Could the New BA.2.75 Sub-Variant Cause the Emergence of a Global Epidemic of COVID-19? A Scoping Review حسب Nour Shaheen (14034758)

"…As a result of new mutations in its spike protein, most of which occur in its receptor binding site, the Omicron variant appears to be more transmissible and less resistant to vaccination and antibody response. Understanding Omicron’s virology and mutations is essential to developing diagnostic and therapeutic methods. …"