Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells by Nihal AlMuraikhi (6002234)

“…We identified γ-secretase inhibitor (LY411575) as a potent regulator of osteoblastic differentiation of hBMSC that may be useful as a therapeutic option for treating conditions associated with ectopic bone formation.…”

Potential application of mesenchymal stem cells and their exosomes in lung injury: an emerging therapeutic option for COVID-19 patients by Sara Al-Khawaga (4792761)

“…In this review, we shed light on the mechanistic view of MSC therapeutic role based on preclinical and clinical studies on acute lung injury and ARDS; therefore, offering a unique correlation and applicability in COVID-19 patients. …”

Arginine Deprivation in AML Cells Induces Ferroptosis, a Type of Autophagy-Mediated Cell Death by Tohme, Sara

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Management of chronic myeloid leukaemia: current treatment options, challenges, and future strategies by Salma Younes (6424865)

“…We also discuss future approaches, such as gene-editing techniques in the context of CML, as potential therapeutic strategies.</p><h2>Other Information</h2><p dir="ltr">Published in: Hematology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1080/16078454.2023.2196866" target="_blank">https://dx.doi.org/10.1080/16078454.2023.2196866</a></p>…”

Efficacy And Safety of Cannabidiol on Juvenile Diabetes Outcomes in Male Rats by Awkar, Nai

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Exploring the clinical potentials of zuranolone in managing postpartum depression: A new therapeutic horizon by Abdulqadir J. Nashwan (11659453)

Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications by Jessica Roelands (7516439)

“…With the definition of consensus molecular subtypes (CMSs) based on transcriptomic profiles, multiple characteristics have been proposed to be responsible for the development of the tumor immune microenvironment and corresponding mechanisms of immune escape. In this review, a detailed description of proposed immune phenotypes as well as their interaction with different therapeutic modalities will be provided. …”

Therapeutic applications of nanobots and nanocarriers in cancer treatment by Zaitoon Khan (22504295)

“…<p dir="ltr">Cancer remains a pressing global health concern, burdening individuals, families, and healthcare systems worldwide, mainly because of the limited availability of therapeutic options. …”

Safety and effectiveness of interference RNA (RNAi) based therapeutics in cardiac failure: A systematic review by Muhammad Nabeel Saddique (19757076)

“…</p><h3>Conclusion</h3><p dir="ltr">RNAi therapeutics are novel treatment option for improving cardiac function because their high target specificity, ability to target genes that conventional drugs struggle to reach and potential for long-lasting effects. …”

Curcumin and Derivatives in Nanoformulations with Therapeutic Potential on Colorectal Cancer by Sourour Idoudi (14153457)

Porous beta titanium alloy coated with a therapeutic biopolymeric composite to improve tribomechanical and biofunctional balance by Ernesto J., Delgado-Pujol

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Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications by Gulab Sher (12984698)

“…</p><h2>Other Information</h2><p dir="ltr">Published in: Seminars in Cancer Biology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.semcancer.2020.08.009" target="_blank">https://dx.doi.org/10.1016/j.semcancer.2020.08.009</a></p>…”

Glycation in Alzheimer’s Disease and Type 2 Diabetes: The Prospect of Dual Drug Approaches for Therapeutic Interventions by Sama Ayoub (15430987)

“…<p dir="ltr">As global life expectancy increases, the prevalence of neurodegenerative diseases like Alzheimer’s disease (AD) continues to rise. Since therapeutic options are minimal, a deeper understanding of the pathophysiology is essential for improved diagnosis and treatments. …”

EGFR and c-MET Cooperate to Enhance Resistance to PARP Inhibitors in Hepatocellular Carcinoma by Qiongzhu Dong (5156150)

“…To ensure therapeutic efficacy of PARPi against HCC, a disease often diagnosed at intermediate to advanced stages with no effective treatment options, it is critical to identify not only biomarkers to predict PARPi resistance but also rational treatments to overcome this. …”

HbA1c over 8.5% is not predictive of increased infection rate following penile prosthesis implant surgery in diabetic patients with erectile dysfunction by Raidh Talib (14779198)

“…Penile prosthesis implantation is an efficient therapeutic option for erectile dysfunction, but not without risk, as infection remains a prominent concern. …”

A possible culprit for refractory angina by Nature Research (16552612)

“…The new findings suggest that elevated lipoprotein(a) levels may play a causative role in the condition, and that reducing levels of this lipoprotein could be a viable therapeutic option for the patients.…”

Aprocitentan: a new emerging prospect in the pharmacotherapy of hypertension by Lina Naseralallah (14146465)

“…It delivers exciting prospects for future therapeutic options in the setting of RH and expands insights into its pathophysiology. …”

Minimally invasive endodontics: a new era for pulpotomy in mature permanent teeth by Nebu Philip (14779318)

“…<p dir="ltr">Emerging clinical and histologic evidence is challenging the long-established dogma that root canal treatment (RCTx) is the only therapeutic option for preservation of vital mature permanent teeth diagnosed with irreversible pulpitis or carious pulp exposure. …”

Cardiovascular Efficacy and Safety of Finerenone: A Meta‐Analysis of Randomized Controlled Trials by Mushood Ahmed (19231379)

“…<h3>Background</h3><p dir="ltr">Finerenone, a nonsteroidal mineralocorticoid receptor antagonist, has emerged as a novel therapeutic option for the management of patients with diabetes, chronic kidney disease, or heart failure. …”

Efficacy and safety of ibrutinib in central nervous system lymphoma: A systematic review and meta-analysis by Jaber H. Jaradat (21632849)

“…Although radiation and chemotherapy, particularly high-dose <u>methotrexate</u> (HD-MTX), are effective treatments, the relapse rates remain high, prompting the exploration of novel therapeutic options.<u> Ibrutinib</u>, an irreversible <u>Bruton tyrosine kinase</u> (BTK) inhibitor, has shown promise in various B-cell <u>malignancies</u>, including <u>CNSL.…”