Characterizing the Effect of Arginine Deprivation on Autophagic Response in Breast Cancer cells by Haidar, Fatemah

“…In this project, we first inspected ASS-1 expression in human breast cancer patients and found that it decreases progressively with tumorigenesis and metastasis. …”
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The therapeutic potential of matcha tea: A critical review on human and animal studies by Sara Sokary (17337724)

The Protective Effects of Daucus carota L. ssp. carota and Cannabis sativa L. Extracts against Cisplatin Induced Nephrotoxicity in Animal Models by Al Toufaily, Sahar

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Chronic reduction of store operated Ca²⁺ entry is viable therapeutically but is associated with cardiovascular complications by Fang Yu (156838)

“…Given its central role in immune cell activation, SOCE has been a therapeutic target for autoimmune and inflammatory diseases. …”

Tolfenamic Acid Derivatives: A New Class of Transcriptional Modulators with Potential Therapeutic Applications for Alzheimer’s Disease and Related Disorders by Jaunetta Hill (18255631)

“…Specific levels of SP1-driven genes and AD biomarkers such as amyloid precursor protein (APP) and Tau proteins were also decreased as part of this targeted systemic response. …”

A Severe Case of Overlap of Morphea and Eosinophilic Fasciitis after Burn Injuries by Hania Sami (21436013)

“…</p><h3>Conclusion</h3><p dir="ltr">Generalized morphea with concomitant EF indicates some degree of therapeutic resistance and poor prognosis with a low quality of life. …”

Evaluation of cationic channel TRPV2 as a novel biomarker and therapeutic target in Leukemia-Implications concerning the resolution of pulmonary inflammation by Kodappully S. Siveen (4246150)

“…Challenging lung airway epithelial cells (AECs) with LBCs decreased (by more than 50%) transepithelial resistance (TER) denoting barrier function alteration. …”

Targeting arginine auxotrophy in pancreatic cancer cells using human recombinant arginase I-induced arginine deprivation. (c2017) by Khalil, Nathalie

“…Therefore, there’s a need for more effective and selective therapeutic approaches for targeting PC. In this study, we examined the mechanisms of arginine auxotrophy in PC cell lines. …”
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Potential mechanisms of human recombinant arginase I (Co)-PEG5000 [HuArgI (CO) - PRG5000] induced cytotoxicity in glioblastoma cells. (c2018) by El Jawhari, Yassmine

“…Due to the resistance and complexity of the tumor itself, it is characterized by a low survival rate and decreased prognosis. Therefore, more selective and efficient therapeutic methods for targeting GBM are needed. …”
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Cytotoxicity of Arginine Deprivation to AML Cells is Mediated by Autophagy by Taki, Fatima

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Daucus Carota oil extract, a chemotherapeutic agent, acts as an antidepressant that promotes resilience to chronic social defeat stress by Houbeika, Rouba

“…Our results suggest that different components of DCOE are responsible for its preventative effects as compared its therapeutic effects. …”
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DNAJB3 attenuates metabolic stress and promotes glucose uptake by eliciting Glut4 translocation by Abdelilah Arredouani (10914455)

“…Using JNK1- and IKKβ-dependent luciferase reporters, we show a marked decrease in luciferase activity by DNAJB3 in response to PMA and TNF-α that was consistent with a decrease in the translocation of p65/NF-κB to the nucleus in response to LPS. …”

Transfusion of Plasma from Young Exercise mice ameliorates Aging-associated Cognitive Impairments on Learning and Memory through activation of Autophagy by Khoury, Reine

“…In old animals, damaged proteins accumulate in neurons since autophagy, a catabolic process responsible for organelle and protein degradation, decreases. …”
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Glycation in Alzheimer’s Disease and Type 2 Diabetes: The Prospect of Dual Drug Approaches for Therapeutic Interventions by Sama Ayoub (15430987)

“…Insulin resistance, a hallmark of T2DM, further complicates AD pathogenesis by promoting tau hyperphosphorylation and Aβ plaque accumulation. …”

1787 evaluation of transperineal prostatic administration of a PSA-activasted protoxin (PRX302) in men with luts secondary to BPH by Elhilali, Mostafa

“…The IPSS still showed a decrease of 4.3 points at 2 years post-treatment. However, no clear dose response was observed and Qmax did not increase in this study. …”
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Percutaneous Aspiration Irrigation Drainage Technique in the Management of Septic Arthritis in Children by Hayek, Toni

“…The draining system was removed when clinical improvement (namely apyrexia) and the decrease of biological inflammatory response were obtained. …”
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Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy by Ajaz A. Bhat (12984701)

“…The complex and dynamic interactions of the secreted cytokines, chemokines, growth factors, and their receptors mediate chronic inflammation and immunosuppressive TME favoring tumor progression, metastasis, and decreased response to therapy. The molecular changes in the TME are used as biological markers for diagnosis, prognosis, and response to treatment in patients. …”

Combinatory effect of diet and exercise on brain derived neurotrophic factor expression, cognitive function and behavioral phenotypes of psychiatric disorders. (c2017) by Abou Haidar, Edwina T.

“…BDNF levels are dramatically decreased in the adult brain in response to stress and are elevated by increased exercise. …”
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Investigation of the Effect of Imatinib and Hydroxyurea Combination Therapy on Hematological Parameters and Gene Expression in Chronic Myeloid Leukemia (CML) Patients by Esraa K. Al-Amleh (16023071)

“…Several treatments, including chemotherapy, radiation, hormone treatment, and immunological therapy, can be used to control this condition. The therapeutic impact on leukemic individuals varies, and the response to therapy varies between patients due to disease heterogeneity. …”

The Antioxidant and Pro-apoptotic effects of Sternbergia clusiana Bulb Ethanolic Extract on Breast Cancer Cells in vitro by El Samarji, Mona

“…The prominent decrease in ROS levels upon treatment confirmed the antioxidant property of the extract being investigated, highlighting the promising effect of SbBEE in breast cancer treatment.…”
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