Successful endoscopic management of gastrojejunal anastomotic strictures after Roux-en-Y gastric bypas حسب Azar, Riad

"…Objective To evaluate the clinical outcomes and therapeutic response to through-the-scope balloon dilation performed to treat anastomotic strictures after Roux-en-Y gastric bypass surgery. …"
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RHOG activates RAC1 through CDC42 leading to tube formation in vascular endothelial cells حسب El Atat, Oula

"…While knocking down either RHO, GTPase did not affect p-AKT levels, and p-ERK decreased in response to the knocking down of RHOG, CDC42 or RAC1. …"
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In vitro ischemia suppresses hypoxic induction of hypoxia-inducible factor-1α by inhibition of synthesis and not enhanced degradation حسب Sleiman, Sama F.

"…Hypoxia-inducible factor (HIF) mediates a broad, conserved adaptive response to hypoxia, and the HIF pathway is a potential therapeutic target in cerebral ischemia. …"
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Finding novel targets for the treatment and reversal of type 2 diabetes mellitus and obesity حسب Imran Ramzan (15430807)

"…Individually, both valine (245 ± 33 to 105 ± 23 µmol/L; p < 0.0001), and leucine (130 ± 20 to 75 ± 13 µmol/L; p < 0.05), decreased significantly in response to the BCAA-restricted diet. …"

Immunomodulatory effects of tumor Lactate Dehydrogenase C (LDHC) in breast cancer حسب Adviti Naik (673163)

"…</p><h3>Conclusions</h3><p dir="ltr">Our findings suggest that targeting LDHC could enhance anti-tumor immune responses by modulating cytokine and chemokine secretion in addition to impairing immune checkpoint signaling. …"

3D Tissue-Engineered Vascular Drug Screening Platforms: Promise and Considerations حسب Isra Marei (11312895)

"…<p dir="ltr">Despite the efforts devoted to drug discovery and development, the number of new drug approvals have been decreasing. Specifically, cardiovascular developments have been showing amongst the lowest levels of approvals. …"

Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells حسب Nihal AlMuraikhi (6002234)

"…Similarly, we observed decreased in vivo ectopic bone formation. Global gene expression profiling of BMS-833923-treated compared to vehicle-treated control cells, identified 348 upregulated and 540 downregulated genes with significant effects on multiple signaling pathways, including GPCR, endochondral ossification, RANK-RANKL, insulin, TNF alpha, IL6, and inflammatory response. …"

The effect of microbiome therapy on COVID-19-induced gut dysbiosis: A narrative and systematic review حسب Mahmoud Yousef (9900837)

"…These interventions reduced mortality rates, decreased hospital stays, improved oxygen saturation levels, alleviated gastrointestinal symptoms, enhanced immune response, and improved cognition.…"

Deciphering the In vitro Role of microRNAs miR-21-3p and miR-222-5p In the Regulation of Clostridioides difficile Flagellin-Induced Inflammation حسب Salman, Zeina

"…These findings underscore the roles of miR-222-5p and miR-21-3p as potential regulators of FliC-induced inflammation and provide insight into the molecular mechanisms underlying C. difficile-associated inflammatory responses. Future studies could explore their therapeutic potential in mitigating intestinal inflammation in vivo in mouse model of C. difficile infections.…"
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The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms حسب Farah Karam (22330564)

"…While the incidence and mortality of CRC have decreased overall due to better screening, rates in adults under 50 have risen. …"

P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis حسب Milane, Aline

"…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with little therapeutics available: riluzole is the only drug approved in its treatment. …"
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