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Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy
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Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance
Published 2024“…This diversity, known as cancer cell plasticity, confers cancer cells the ability to change in response to their environment, leading to increased tumor diversity and drug resistance. This review explores the intricate landscape of cancer cell plasticity, offering a deep dive into the cellular, molecular, and genetic mechanisms that underlie this phenomenon. …”
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Therapeutic Impact of P-PENT, P-HEX and 5CLSS (IV) Platinum (IV) complexes on Acute Myeloid Leukemia in vitro and in vivo
Published 2025“…Platinum (II)-based complexes, such as cisplatin and carboplatin, are widely known for their anticancer activity against various types of cancers. While resistance has limited their efficacy, a growing interest in platinum (IV) complexes has recently grown to overcome this challenge. …”
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Targeting arginine auxotrophy in pancreatic cancer cells using human recombinant arginase I-induced arginine deprivation. (c2017)
Published 2017“…Normal cells, on the other hand, were resistant to HuArgI (Co)-PEG5000-induced arginine deprivation. …”
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Potential mechanisms of human recombinant arginase I (Co)-PEG5000 [HuArgI (CO) - PRG5000] induced cytotoxicity in glioblastoma cells. (c2018)
Published 2018“…Hence, HuArgI (Co)-PEG5000 is an efficient and selective therapeutic method for targeting GBM.…”
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Investigating The Efficacy of Ruxolitinib and CHIR-99021 in Targeting Pediatric Neuroblastoma Stem Cells
Published 2021“…Western blot analysis showed significant decrease in stem cell markers SOX-2 and Oct-4, and tumorigenic protein HMGA1, whereas it showed significant increase in apoptotic markers cleaved PARP and cleaved caspase-3. …”
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Screening for antiretroviral drug resistance among treatment-naive human immunodeficiency virus type 1-infected individuals in Lebanon
Published 2014“…Introduction: Antiretroviral therapy (ART) has been successful at decreasing the morbidity and mortality associated with human immunodeficiency virus type 1 (HIV-1) infection. …”
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Hexokinase-linked glycolytic overload and unscheduled glycolysis in hyperglycemia-induced pathogenesis of insulin resistance, beta-cell glucotoxicity, and diabetic vascular complic...
Published 2024“…Correction of HK2 dysregulation is proposed as a novel therapeutic target. Pharmacotherapy addressing it corrected insulin resistance in overweight and obese subjects in clinical trial. …”
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Immunoprofile of childhood diabetes
Published 2023“…When transcriptomic data was interrogated, an imbalance between ITGA4/ ITGB1 was observed in all groups where CD49d showed increased expression. Associated with these findings, anti-inflammatory Treg cytokines including IL-10 were decreased in T2D patients and elevated plasma levels of IL-17, which contributes to the insulin resistance and inflammation were observed.…”
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Inflammatory protein signatures in individuals with obesity and metabolic syndrome
Published 2023“…<p dir="ltr">There is variability in the metabolic health status among individuals presenting with obesity; some may be metabolically healthy, while others may have developed the metabolic syndrome, a cluster including insulin resistance, hypertension, dyslipidemia, and increased risk of cardiovascular disease and type 2 diabetes. …”
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DNAJB3/HSP-40 cochaperone improves insulin signaling and enhances glucose uptake in vitro through JNK repression
Published 2015“…In summary, our results shed the light on the possible role of DNAJB3 in improving insulin sensitivity and glucose uptake through JNK repression and suggest that DNAJB3 could be a potential target for therapeutic treatment of obesity-induced insulin resistance.…”
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Alpha lipoic acid attenuates ER stress and improves glucose uptake through DNAJB3 cochaperone
Published 2020“…A similar increase in DNAJB3 mRNA was also observed in HepG2 cells. …”
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Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes
Published 2023“…<p dir="ltr">Several pathways and/or genes have been shown to be dysregulated in obesity-induced insulin resistance (IR) and type 2 diabetes (T2D). We previously showed, for the first time, impaired expression of DNAJB3 mRNA and protein in subjects with obesity, which was concomitant with increased metabolic stress. …”
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From metabolic dysregulation to neurodegenerative pathology: the role of hyperglycemia, oxidative stress, and blood-brain barrier breakdown in T2D-driven Alzheimer’s disease
Published 2025“…This review focuses on the potential mechanisms associated with these two diseases, like insulin resistance, inflammation, oxidative damage, mitochondrial injury, and cell death. …”
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Bevacizumab and neovascular age related macular degeneration
Published 2011“…The mean number of letters gained, decrease in CRT, and number of injections were 8 letters, 125.3 µm, and 4.3 injections, respectively. …”
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The Human Microbiome in Chronic Kidney Disease: A Double-Edged Sword
Published 2022“…Fluctuations in the urinary microbiome are linked to increased susceptibility to infection and antibiotic resistance. …”
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Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia
Published 2019“…Although chemotherapeutic approaches have been achieving successful remission for the majority of cases of childhood ALL, development of resistance to chemotherapy has been observed. Thus, new therapeutic approaches are required to improve patient's prognosis. …”
