Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B‑Cell Lymphoma by Matthew M. Weiss (1656997)

“…IRAK4 signaling is driven by its catalytic and scaffolding functions, necessitating complete removal of this protein and its escape mechanisms for complete therapeutic suppression. Herein, we describe the identification and characterization of a dual-functioning molecule, KT-413 and show it efficiently degrades IRAK4 and the transcription factors Ikaros and Aiolos. …”

Figure S4 from BRD4 Levels Determine the Response of Human Lung Cancer Cells to BET Degraders That Potently Induce Apoptosis through Suppression of Mcl-1 by Dan Zong (5949824)

Figure S2 from BRD4 Levels Determine the Response of Human Lung Cancer Cells to BET Degraders That Potently Induce Apoptosis through Suppression of Mcl-1 by Dan Zong (5949824)

Figure S1 from BRD4 Levels Determine the Response of Human Lung Cancer Cells to BET Degraders That Potently Induce Apoptosis through Suppression of Mcl-1 by Dan Zong (5949824)

Figure S3 from BRD4 Levels Determine the Response of Human Lung Cancer Cells to BET Degraders That Potently Induce Apoptosis through Suppression of Mcl-1 by Dan Zong (5949824)

Figure S8 from BRD4 Levels Determine the Response of Human Lung Cancer Cells to BET Degraders That Potently Induce Apoptosis through Suppression of Mcl-1 by Dan Zong (5949824)

Additional file 3 of COX-2 inhibition as a therapeutic strategy for bone loss in Staphylococcus aureus osteomyelitis by Yuhui Chen (150020)

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Additional file 1 of COX-2 inhibition as a therapeutic strategy for bone loss in Staphylococcus aureus osteomyelitis by Yuhui Chen (150020)

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Additional file 2 of COX-2 inhibition as a therapeutic strategy for bone loss in Staphylococcus aureus osteomyelitis by Yuhui Chen (150020)

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DataSheet1_SPHK Inhibitors and Zoledronic Acid Suppress Osteoclastogenesis and Wear Particle-Induced Osteolysis.docx by Minghui Gu (803521)

“…<p>Background: Inflammatory osteolysis induced by wear particles is the major cause of prosthetic loosening after artificial joint replacement, and its prevention and treatment are difficult worldwide. …”

DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders by Melissa Lim (15397820)

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DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders by Melissa Lim (15397820)

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DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders by Melissa Lim (15397820)

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DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders by Melissa Lim (15397820)

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DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders by Melissa Lim (15397820)

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DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders by Melissa Lim (15397820)

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DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders by Melissa Lim (15397820)

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S4. IGF-1R inhibition did not decrease FoxO1 protein levels in MCF-7 cells. from IGF-1 Receptor Modulates FoxO1-Mediated Tamoxifen Response in Breast Cancer Cells by Ali Vaziri-Gohar (13862857)

DataSheet5_Pan-cancer analysis identifies proteasome 26S subunit, ATPase (PSMC) family genes, and related signatures associated with prognosis, immune profile, and therapeutic resp... by Hui Jia (638620)

“…</p><p>Conclusion: Overall, our results provide deep insight into PSMC genes in LUAD, especially the prognostic effect and related immune profile that may predict therapeutic responses.</p>…”

DataSheet2_Pan-cancer analysis identifies proteasome 26S subunit, ATPase (PSMC) family genes, and related signatures associated with prognosis, immune profile, and therapeutic resp... by Hui Jia (638620)

“…</p><p>Conclusion: Overall, our results provide deep insight into PSMC genes in LUAD, especially the prognostic effect and related immune profile that may predict therapeutic responses.</p>…”