Data Sheet 1_Endothelial Zmiz1 modulates developmental angiogenesis in the retina.pdf حسب Nehal R. Patel (18522672)

"…Mechanisms for transcription factor involvement in the regulation of endothelial cell dynamics and angiogenesis have become better understood, however much remains unknown, especially the role of non-DNA binding transcriptional cofactors. Here, we show that Zmiz1, a transcription cofactor, is enriched in the endothelium and critical for embryonic vascular development, postnatal retinal angiogenesis, and pathological angiogenesis in a model of oxygen-induced retinopathy (OIR). …"

Table 1_Contact load is associated with both contact and non-contact injuries in rugby union.docx حسب Yusuke Iwasaki (3547868)

"…Objective<p>Managing matches and training loads is crucial for injury prevention. Contact load is a defining feature of rugby union, and World Rugby has proposed its management as a key strategy for the prevention of injuries. …"

Image 2_Modulation of fenestrated vasculature in the median eminence and area postrema in response to neurotoxin exposure and its impairment in aging.tif حسب Viana Q. Pham (22081163)

"…<p>Effective communication between the brain and peripheral tissues is crucial for homeostasis and health, and its impairment is a defining feature of aging. Circumventricular organs, characterized by the presence of fenestrated capillaries and absence of a blood–brain barrier (BBB), play a crucial role in controlling substance exchange between the brain and the blood. …"

Image 1_Modulation of fenestrated vasculature in the median eminence and area postrema in response to neurotoxin exposure and its impairment in aging.tif حسب Viana Q. Pham (22081163)

"…<p>Effective communication between the brain and peripheral tissues is crucial for homeostasis and health, and its impairment is a defining feature of aging. Circumventricular organs, characterized by the presence of fenestrated capillaries and absence of a blood–brain barrier (BBB), play a crucial role in controlling substance exchange between the brain and the blood. …"

smFISH probe sequences used in this study. حسب Grace E. Johnson (21376787)

"…The <i>Vibrio cholerae</i> pathogen forms biofilms from single founder cells that, via cell division, mature into three-dimensional structures with distinct, yet reproducible, regional architectures. To define mechanisms underlying biofilm developmental transitions, we establish a single-molecule fluorescence in situ hybridization (smFISH) approach that enables accurate quantitation of spatiotemporal gene-expression patterns in biofilms at cell-scale resolution. smFISH analyses of <i>V. cholerae</i> biofilm regulatory and structural genes demonstrate that, as biofilms mature, overall matrix gene expression decreases, and simultaneously, a pattern emerges in which matrix gene expression becomes largely confined to peripheral biofilm cells. …"

Strains used in this study. حسب Grace E. Johnson (21376787)

"…The <i>Vibrio cholerae</i> pathogen forms biofilms from single founder cells that, via cell division, mature into three-dimensional structures with distinct, yet reproducible, regional architectures. To define mechanisms underlying biofilm developmental transitions, we establish a single-molecule fluorescence in situ hybridization (smFISH) approach that enables accurate quantitation of spatiotemporal gene-expression patterns in biofilms at cell-scale resolution. smFISH analyses of <i>V. cholerae</i> biofilm regulatory and structural genes demonstrate that, as biofilms mature, overall matrix gene expression decreases, and simultaneously, a pattern emerges in which matrix gene expression becomes largely confined to peripheral biofilm cells. …"

Development of an optimized framework for delivery of and adherence to exercise-based care for persons with subacromial pain syndrome حسب Lise Kronborg Poulsen (22750757)

"…<p>Subacromial pain syndrome (SAPS) is a common musculoskeletal condition compromising physical function. …"

<i>Salmonella enterica </i>pangenome graph and variant call data for 539,283 genomes حسب ADAM RIVERS (18387663)

"…<p dir="ltr"><i>Salmonella</i> pangenome graph and variant call data for 539,283 genomes</p><h3>Description:</h3><p dir="ltr"><i>Salmonella enterica</i> causes human disease and decreases agricultural production. The overall goals of this project is to generate a large database of <i>S. enterica</i> variants with 539,283 samples and 236,069 features for applications in machine learning and genomics. …"

Image2_Lipid profiling of RON and DEK-dependent signaling in breast cancer guides discovery of gene networks predictive of poor outcomes.tif حسب Sara Vicente-Muñoz (13730629)

"…Lipid-related genes were then queried to define a signature that predicts poor outcomes for patients with breast cancer patients. …"

Image1_Lipid profiling of RON and DEK-dependent signaling in breast cancer guides discovery of gene networks predictive of poor outcomes.tif حسب Sara Vicente-Muñoz (13730629)

"…Lipid-related genes were then queried to define a signature that predicts poor outcomes for patients with breast cancer patients. …"

Ultimate Lateral resistance of Tetrapod Pile Foundation in Rate-dependent and Strain-softening Clay حسب Zi-hao Zhao (21085578)

"…The results show that the ultimate lateral resistance gradually decreases with <b>a reduction in</b> strain-dependent parameters. …"

Table 1_Drug tapering in animal research: current practices and challenges.docx حسب Yatong Zhang (10114667)

"…</p>Conclusion<p>The methods of drug tapering in animal studies are influenced by multiple factors, including disease characteristics, treatment duration, animal tolerance, and specific goals. There remains a need for further refinement in tapering schedules, methods, and milestones, and the establishment of relevant evaluation metrics to better define tapering timing.…"

Metabolome at time-points during and after pregnancy in NW and OB women. حسب Ulrika Andersson-Hall (8965229)

"…<p>The first two components in a PCA showing 362 measured NW and OB samples, after removal of one outlier, using 25 metabolite NMR concentration measurements. …"

Assessing sleep homeostasis in real-world data. حسب Balaji Goparaju (22379158)

"…Example of repeated sleep restriction protocol (SR), with decreased sleep opportunity. C. Schematic of real-world sleep data, aligned to the start of each night for visual convenience, to visualize the approach to computing the baseline (median; dotted line) and defining short night (S) threshold (gray dotted line), and the next night (N) analyzed for homeostatic response. …"

Image 1_Peripheral monocyte transcriptional signatures of inflammation and oxidative stress in Parkinson’s disease.tif حسب Aaron D. Thome (12907298)

"…After stratification by Hoehn & Yahr (H&Y) stage, inflammatory transcripts IL-6, IL-1β, ARG1, CD163, and CCR2 were upregulated in PD monocytes and increased with disease burden. Furthermore, PPARGC1A (PGC-1α), GPX4, NFE2L2 (NRF2), and SIRT3 decreased with increasing disease burden, while only SIRT1 expression increased, reflecting oxidative stress and mitochondrial dysregulation. …"

Table 1_Peripheral monocyte transcriptional signatures of inflammation and oxidative stress in Parkinson’s disease.xlsx حسب Aaron D. Thome (12907298)

"…After stratification by Hoehn & Yahr (H&Y) stage, inflammatory transcripts IL-6, IL-1β, ARG1, CD163, and CCR2 were upregulated in PD monocytes and increased with disease burden. Furthermore, PPARGC1A (PGC-1α), GPX4, NFE2L2 (NRF2), and SIRT3 decreased with increasing disease burden, while only SIRT1 expression increased, reflecting oxidative stress and mitochondrial dysregulation. …"

Image 2_Peripheral monocyte transcriptional signatures of inflammation and oxidative stress in Parkinson’s disease.tif حسب Aaron D. Thome (12907298)

"…After stratification by Hoehn & Yahr (H&Y) stage, inflammatory transcripts IL-6, IL-1β, ARG1, CD163, and CCR2 were upregulated in PD monocytes and increased with disease burden. Furthermore, PPARGC1A (PGC-1α), GPX4, NFE2L2 (NRF2), and SIRT3 decreased with increasing disease burden, while only SIRT1 expression increased, reflecting oxidative stress and mitochondrial dysregulation. …"

Data Sheet 1_Characterizing the immune infiltrate in secondary syphilis: implications for transmission and pathology.docx حسب Irène Gallais Sérézal (20930579)

"…Additionally, PBMCs from healthy individuals and either primary or MyD88 knock-out keratinocytes were exposed to live Treponema pallidum cells to define initial skin responses to the bacteria.</p>Results<p>Immunohistochemistry of secondary syphilis skin lesions showed a polymorphous immune infiltrate with colocalization of T cells, B cells and antigen–presenting cells. …"