Showing 1 - 20 results of 2,371 for search '(( defined ((key decrease) OR (mean decrease)) ) OR ( a ((latest decrease) OR (marked decrease)) ))', query time: 0.66s Refine Results
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    Key safety measures including adverse events. by Anuja Dokras (8679261)

    Published 2025
    “…As there is a lack of robust evidence on the impact of these first-line medications on cardiovascular disease (CVD) risk, we compared the effect of COCPs, metformin or both on prevalence of metabolic syndrome (MetS) in participants with hyperandrogenic PCOS and hypothesized that COCPs would increase prevalence of MetS while metformin would decrease prevalence of MetS.</p><p>Methods and findings</p><p>We conducted a multicenter, double-blind, double-dummy, randomized trial (COMET-PCOS) in participants between ages ≥18 and ≤40 years and body mass index (BMI) ≥25 kg/m<sup>2</sup> and ≤ 48 kg/m<sup>2</sup> with hyperandrogenic PCOS (defined by the Rotterdam criteria). …”
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