Data Sheet 1_Characterizing the immune infiltrate in secondary syphilis: implications for transmission and pathology.docx by Irène Gallais Sérézal (20930579)

“…Additionally, PBMCs from healthy individuals and either primary or MyD88 knock-out keratinocytes were exposed to live Treponema pallidum cells to define initial skin responses to the bacteria.</p>Results<p>Immunohistochemistry of secondary syphilis skin lesions showed a polymorphous immune infiltrate with colocalization of T cells, B cells and antigen–presenting cells. …”

smFISH probe sequences used in this study. by Grace E. Johnson (21376787)

“…The <i>Vibrio cholerae</i> pathogen forms biofilms from single founder cells that, via cell division, mature into three-dimensional structures with distinct, yet reproducible, regional architectures. To define mechanisms underlying biofilm developmental transitions, we establish a single-molecule fluorescence in situ hybridization (smFISH) approach that enables accurate quantitation of spatiotemporal gene-expression patterns in biofilms at cell-scale resolution. smFISH analyses of <i>V. cholerae</i> biofilm regulatory and structural genes demonstrate that, as biofilms mature, overall matrix gene expression decreases, and simultaneously, a pattern emerges in which matrix gene expression becomes largely confined to peripheral biofilm cells. …”

Strains used in this study. by Grace E. Johnson (21376787)

“…The <i>Vibrio cholerae</i> pathogen forms biofilms from single founder cells that, via cell division, mature into three-dimensional structures with distinct, yet reproducible, regional architectures. To define mechanisms underlying biofilm developmental transitions, we establish a single-molecule fluorescence in situ hybridization (smFISH) approach that enables accurate quantitation of spatiotemporal gene-expression patterns in biofilms at cell-scale resolution. smFISH analyses of <i>V. cholerae</i> biofilm regulatory and structural genes demonstrate that, as biofilms mature, overall matrix gene expression decreases, and simultaneously, a pattern emerges in which matrix gene expression becomes largely confined to peripheral biofilm cells. …”

Comparative analysis of human and mouse ovaries across age, DOI: 10.1126/science.adx0659, C57BL/6 Mouse Seurat Object (GSE290742) by Diana Laird (22671017)

“…<p dir="ltr">The mouse is a tractable model for human ovarian biology, however its utility is limited by incomplete understanding of how transcription and signaling differ interspecifically and with age. …”

Comparative analysis of human and mouse ovaries across age, DOI: 10.1126/science.adx0659, Human Seurat Object (GSE290743 and TSP27, TSP28, TSP30, https://tabula-sapiens.sf.czbiohub... by Diana Laird (22671017)

“…<p dir="ltr">The mouse is a tractable model for human ovarian biology, however its utility is limited by incomplete understanding of how transcription and signaling differ interspecifically and with age. …”

Comparative analysis of human and mouse ovaries across age, DOI: 10.1126/science.adx0659, Seurat object of subsetted human oocytes from this study and from Wu et al. 2024 (https://... by Diana Laird (22671017)

“…<p dir="ltr">The mouse is a tractable model for human ovarian biology, however its utility is limited by incomplete understanding of how transcription and signaling differ interspecifically and with age. …”

Comparative analysis of human and mouse ovaries across age, DOI: 10.1126/science.adx0659, Seurat object of subsetted human granulosa cells from this study and from Wu et al. 2024 (... by Diana Laird (22671017)

“…<p dir="ltr">The mouse is a tractable model for human ovarian biology, however its utility is limited by incomplete understanding of how transcription and signaling differ interspecifically and with age. …”

Comparative analysis of human and mouse ovaries across age, DOI: 10.1126/science.adx0659, Seurat Object of subsetted C57BL/6 Mouse Oocytes from this study (GSE290742) merged with t... by Diana Laird (22671017)

“…<p dir="ltr">The mouse is a tractable model for human ovarian biology, however its utility is limited by incomplete understanding of how transcription and signaling differ interspecifically and with age. …”

Data_Sheet_1_Banxia-Yiyiren alleviates insomnia and anxiety by regulating the gut microbiota and metabolites of PCPA-induced insomnia model rats.zip by Liang Wang (23021)

“…Objective<p>This study aims to clearly define the effects of Banxia-Yiyiren on the gut microbiota and its metabolites in a para-chlorophenylalanine-induced insomnia model and the possible underlying mechanisms involved.…”

Data Sheet 1_Immune complexes-mediated activation of neutrophils in systemic lupus erythematosus is dependent on RNA recognition by toll-like receptor 8.docx by Ting Wang (16292)

“…We previously demonstrated that ribonucleoprotein (RNP) immune complexes (ICs) promoted neutrophil activation in a TLR7/8-dependent manner. However, it remains unclear if this mechanism occurs in patients. …”

<i>Salmonella enterica </i>pangenome graph and variant call data for 539,283 genomes by ADAM RIVERS (18387663)

“…<p dir="ltr"><i>Salmonella</i> pangenome graph and variant call data for 539,283 genomes</p><h3>Description:</h3><p dir="ltr"><i>Salmonella enterica</i> causes human disease and decreases agricultural production. The overall goals of this project is to generate a large database of <i>S. enterica</i> variants with 539,283 samples and 236,069 features for applications in machine learning and genomics. …”

Table 1_TLR4 and prostaglandin pathways at the crossroads of endotoxemia-induced lipolysis.docx by Miguel Chirivi (9677739)

“…LPS also increased the expression of EP2, a PGE₂ receptor, while simultaneously reducing EP4 content. …”

Image 1_TLR4 and prostaglandin pathways at the crossroads of endotoxemia-induced lipolysis.jpeg by Miguel Chirivi (9677739)

“…LPS also increased the expression of EP2, a PGE₂ receptor, while simultaneously reducing EP4 content. …”