Showing 1 - 20 results of 6,490 for search '(( designed ((dna decrease) OR (a decrease)) ) OR ( a ((large decrease) OR (marked decrease)) ))', query time: 0.64s Refine Results
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    Quinoline-Based DNA Methyltransferase Inhibitors Featuring Basic Side Chains: Design, Synthesis, and Insight in Biochemical and Anticancer Cell Properties by Clemens Zwergel (1307868)

    Published 2025
    “…The quinoline DNMT inhibitors <b>4</b>–<b>21</b>, incorporating basic chains, were designed, synthesized, and evaluated for their ability to inhibit DNMT1 and DNMT3<i>A</i>/3L by directly measuring DNA methylation. …”
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    Study Design. by Bryan S. Margulies (21492667)

    Published 2025
    “…Intratumoral administration of MBC-005 increased survival 3.9-fold in mice and significantly decreased tumor volume 4-fold. While many cytotoxic therapies increase p21 expression as a response to DNA damage, MBC-005 increased p21 expression independent cytotoxic DNA damage. …”