Development of Potent and Selective Dual PPARδ/sEH Modulators from an AI-Designed Scaffold by Xiu Ge (13802019)

“…Dual soluble epoxide hydrolase (sEH) inhibition and peroxisome proliferator-activated receptor δ (PPARδ) activation hold promise as designed polypharmacology in metabolic dysfunction and associated liver diseases by improving whole-body energy balance, decreasing hepatic inflammation and lipotoxicity, and providing cardiovascular protection. …”

Cinacalcet administered early in the inactive phase markedly decrease parathyroid Ki-67 index. by Søren Egstrand (10906087)

Map of Pakistan with marked Punjab province. by Sumaira Sumaira (21453523)

Osseointegration of an innovative functionally gradient biomimetic scaffold based on Voronoi-Tessellation for the design of orthopaedic implants by Yuzhu Wang (845659)

“…<p>The geometry and pore size of porous structures have a significant impact on osseointegration in orthopaedic implant design. This study introduced a new approach to designing biomimetic scaffolds using the Voronoi-Tessellation algorithm and additive manufacturing techniques. …”

The parameters of gas exchange markedly decreased in maize <i>zmstomagen1/2</i> mutant compared with in wild type (WT). by Juan-Juan Xu (18590868)

PLB is a target gene of miRNA 221. by Hongyu Li (1332669)

(A) Auxiliary marking points to ensure complete and accurate seating of the prosthesis. by Long Li (6555)

Tissue, days post-infection (dpi) and the top 10 most significant genes with increased and decreased expression with valid gene symbols for the response contrasts. by Gillian P. McHugo (8965919)

Expression of lipid biosynthetic genes is decreased with polyamine depletion. by Yazmin E. Cruz-Pulido (20285238)

Conditional ablation of <i>Ybx1</i> leads to a reduction in cortical progenitor cell pool and a decrease in cortical thickness. by Jian Zhang (1682)

<i>RTTN</i>-mutated organoids exhibit decreased proliferation and increased cell death at early stages. by Justine Guguin (9088672)

Group-level narrow- and broad-band spectral changes after hemispherotomy reveal a marked EEG slowing of the isolated cortex, robust across patients. by Michele Angelo Colombo (22446342)

Repetitive stress induces a decrease in sound-evoked activity. by Ghattas Bisharat (20706928)

“…<p>(a) Left: noise-evoked activity rates at different noise intensities for chronically tracked PPys cells in baseline and repeated stress conditions (<i>N</i> = 5 mice, <i>n</i> = 285 neurons, mean ± SE). …”

General procedure for the synthesis of A and A-c1. by Xueqin lu (22250795)

Cases and ICU admissions throughout the pandemic. by Sixten Melander (22521804)

Disturbance of coherent behaviour leads to a decrease in information transfer. by Hannah Zoller (19688084)

Macrophage-specific IGF-1 overexpression decreases plaque MMP8 and. by Patricia Snarski (22305205)

Evogliptin attenuates the phenotypic switch of VSMCs during CER treatment by decreasing the osteogenesis-associated genes <i>in-vitro.</i> by Razia Rashid Rahil (22772495)

The heart rate was similar among the groups. by Hongyu Li (1332669)

“…Following the overexpression of miRNA 221 in myocardium, there was a marked alleviation of myocardial injury and cardiomyocyte apoptosis and necrosis, significant enhancement of left ventricular systolic function, and marked decrease in the levels of PLB, p-PLB (Ser16), p-PLB (Thr17), caspase 3 and Cyt C, as well as a significant decrease in total calcium levels in myocardium.…”

S1 File - by Hongyu Li (1332669)

“…Following the overexpression of miRNA 221 in myocardium, there was a marked alleviation of myocardial injury and cardiomyocyte apoptosis and necrosis, significant enhancement of left ventricular systolic function, and marked decrease in the levels of PLB, p-PLB (Ser16), p-PLB (Thr17), caspase 3 and Cyt C, as well as a significant decrease in total calcium levels in myocardium.…”