Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model by Christopher C. Marvin (1338228)

“…Mouse PK indicated that <b>6</b> is cleared 10-fold more rapidly than a first-generation GRM payload, resulting in 10-fold lower exposure and 3-fold decrease in Cmax. The anti-mTNF conjugate <b>ADC5</b> fully inhibited inflammation in mouse contact hypersensitivity with minimal effects on corticosterone, a biomarker for systemic GRM effects, at doses up to and including 100 mg/kg. …”

Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model by Christopher C. Marvin (1338228)

“…Mouse PK indicated that <b>6</b> is cleared 10-fold more rapidly than a first-generation GRM payload, resulting in 10-fold lower exposure and 3-fold decrease in Cmax. The anti-mTNF conjugate <b>ADC5</b> fully inhibited inflammation in mouse contact hypersensitivity with minimal effects on corticosterone, a biomarker for systemic GRM effects, at doses up to and including 100 mg/kg. …”

Identification of Gut Microbiota Biomarker Genera Distinguishing Wild and Captive Animals (A) Top 50 discriminative genera selected by random forest classifier, ranked by mean decrease accuracy. by Lin Xu (94491)

First and second mean values and intraclass correlation coefficients (ICCs) of each parameter in pattern electroretinogram. by Soo Ji Jeon (3364214)

Homogenizing experiment: Mean fecal egg counts (FECs), mean relative differences from the grand mean FECs per sample (over 7 observations), standard deviation of the relative diffe... by Felix Bosch (10024550)

Intracellular levels of HSPG core proteins, HS and HPSE are decreased in ER stressed MIN6 cells. by Sarita Dhounchak (10924448)

Comparison of baseline characteristics stratified by the occurrence of ISR > 50%. by Jae-Chan Ryu (2850581)

Proteins from the volcano plot which had notable increases or decreases listed in order of greatest to least magnitude of fold change and split by overall increase or overall decre... by Eiman Y. Ibrahim (10731078)

Number of significant genes and fold change. by Gordon A. Barr (11163243)

“…Adult social behavior was decreased following Shock+mother pairings at both PN5-9 and PN10-14, whereas shock alone had no effect. …”

RDV and EIDD2801 EC₅₀ and fold-change in VeroE6-ACE2-TMPRSS2. by Agnieszka M. Szemiel (10196243)

Illustrations of the SeqFold2D network and the Stralign dataset. by Xiangyun Qiu (316117)

DnaK’s ATPase activity is stimulated by ribosomes and required to reduce protein synthesis. by Carissa Chan (18310140)

Mean of the difference between the RV-GLS value of the expert and trainees in four consecutive groups of 25 fetal heart clips. by Chantelle M. de Vet (16535257)

Mean of the difference between the LV-GLS value of the expert and trainees in four consecutive groups of 25 fetal heart clips. by Chantelle M. de Vet (16535257)

Heatmap of fold-changes of metabolites. by Elena Heidenreich (6940475)

“…HL, i.e., 50 vs. 300 μmol photons m^-2 s^-1) for diploid (2N) and haploid (1N) <i>E</i>. …”

Binary and ordinal logistic regression analysis of predictors for the occurrence of ISR > 50%. by Jae-Chan Ryu (2850581)

Cumulative distribution of EQ-5D-3L utilities decreasingly ordered before and after the onset of cutaneous leishmaniasis symptoms. by Janaína de Pina Carvalho (12152812)

Positional cloning of <i>qNN1</i> on chromosome 16. by Xinxin Li (281237)

VPS34 inhibition decreases intracellular levels of cholesteryl-esters, blocks cholesterol uptake and enhances lysosomal degradation of LDLR. by Marek J. Kobylarz (9292599)

Mean score of school factors by SES over years. by Benti Geleta Buli (15417868)