Showing 81 - 100 results of 17,923 for search '(( e fold decrease ) OR ((( 50 ng decrease ) OR ( 50 ((ng decrease) OR (a decrease)) ))))', query time: 0.54s Refine Results
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    Fold change in EC<sub>50</sub> in all polyene resistant lines of <i>Leishmania spp</i>. by Edubiel A. Alpizar-Sosa (13848145)

    Published 2022
    “…<i>mexicana</i> in DM and E) AmBR-<i>L</i>. <i>infantum</i> in HOMEM. Values higher and lower than 1, indicate a decrease and rise in susceptibility relative to the parental line, respectively. …”
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    First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

    Published 2022
    “…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC<sub>50</sub> value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC<sub>0‑inf</sub> (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”
  17. 97

    First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

    Published 2022
    “…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC<sub>50</sub> value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC<sub>0‑inf</sub> (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”
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    Description of the cohort (N = 118 patients). by Bastien Le Floc’h (14773916)

    Published 2023
    “…An HLA-G plasma level ≤ 50 ng/ml on day 8 after LT was significantly associated with a higher rejection risk. …”