Inflammatory Adipokines Decrease Expression of Two High Molecular Weight Isoforms of Tropomyosin Similar to the Change in Type 2 Diabetic Patients by Stuart A. Savill (3129060)

“…The change in expression in HMW isoforms from TPM1 and TPM4 was replicated in THP1 cells treated with 1 ng/ml TNFα (0.10 and 0.12 v 1.00 respectively) or 10 ng/ml IL-1α (0.17 and 0.14 v 1.00 respectively). …”

Coverage of reference gene panel by assay A to E for reference samples. by Lizhi Yu (12476136)

Subjects:

Decreased THBS1 Protein Levels Translate into Reduced TGF-β Activity by Mark A Samols (30415)

Deletion of <i>Kdm5b</i> in DCs leads to increased cytokine production and decreased Th2 pathology <i>in vivo</i>. by Catherine Ptaschinski (756139)

Folding and stability of GDAP1 as affected by CMT mutations. by Aleksi Sutinen (10039145)

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MiR-132-3p was downregulated in TGF-<i>β</i>1 stimulated Met-5A cells and miR-132-3p mimics and miR-132-3p inhibitor transfected Met-5A cells. by Yangyang Yin (14323701)

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Predicted metabolite levels for each reaction intermediate shown in Figure 7 under conditions in which the NAD+:NADH ratio is 31 (Bennett et al. [26]), or decreased by either 0.1-f... by William R. Cannon (608586)

Binding of <i>PC3/Tis21</i> to the <i>Id3</i> promoter and corresponding decrease of <i>Id3</i> mRNA. by Stefano Farioli-Vecchioli (256006)

“…<p>(<b>A–D</b>) A PC12 cell line carrying an inducible <i>PC3</i> (rat) cDNA under control of the tet-off system (i.e., a tetracycline responsive element TRE-PC3, activated by a tetracycline-regulated transactivator, CMV-tTA, in the absence of doxycycline) was used to analyze the binding of <i>PC3</i> to the <i>Id3</i> promoter, by chromatin immunoprecipitation (ChIP). …”

The prolyl 4-hydroxylase inhibitor GSK360A decreases post-stroke brain injury and sensory, motor, and cognitive behavioral deficits - Fig 4 by Jin Zhou (90734)

Loss of virulence in the SIN kinase mutants is characterized by decreased fungal burden and host response to infection. by Ana Camila Oliveira Souza (8180958)

“…Data are represented as nanograms of <i>A</i>. <i>fumigatus</i> specific DNA in 500 ng of total DNA. * p < 0.02. …”

Delphinidin alters VEGF-A splicing to increase VEGF-A₁₆₅b and decrease total VEGF-A expression. by Megan Stevens (3964886)

“…<p><b>A)</b> Treatment of podocytes with delphinidin chloride (10 μg/ml) under normal glucose (NG; 5 mM glucose + 25 mM mannitol) and high glucose (HG; 30 mM glucose, 1 ng/ml TNFα, 1 ng/ml IL-6, and 100 nM insulin) for 48 hrs increased the protein expression of VEGF-A₁₆₅b relative to total VEGF-A₁₆₅ (quantified in <b>B</b>; *p<0.05 vs NG, †p<0.05 vs HG; n = 3 biological repeats; One-way ANOVA with Bonferroni post-hoc test for comparison between pairs; <b>A</b>—the same blot was first probed with VEGF-A₁₆₅b before stripping and reprobing with panVEGF-A). …”

Gene Ontology analysis reveals biological programs that are decreased during vertebrate tissue regeneration. by Sarah E. Mercer (108441)

Antibody response elicited by SARS-CoV-2 vaccines. by Chris Davis (647632)

PLE-mediated ICP1 inhibition blocks phage burst and decreases phage genome replication. by Brendan J. O’Hara (4096459)

Relative expression (fold-change) of immune genes in mitogen-stimulated splenic lymphocytes. by Chaiwat Monmai (6377270)

Heparin (GAG-hed) inhibits LCR activity of Human Papillomavirus type 18 by decreasing AP1 binding-5 by Rita Villanueva (65963)

“…Nuclear extracts obtained from HeLa cells were exposed to GAG-hed at indicated concentrations for 10 min before labelled probe addition (Panels B and D). On panel A and C, complex specificity is denoted by competition assays with a 100 fold excess of indicated oligonucleotide competitor. …”

Prolonged transforming growth factor (TGF)-βtreatment induced a decrease in total Smad2 and/or Smad3 in many cell strains by Kimberly A Brown (26546)

WT1 siRNA decreases proliferation, pAKT, and Bcl2 expression. by Ayana E. Morales (17756335)

“…</b> RT-qPCR of WT1, p<0.05(*), vFLIP(ns), LANA, p<0.0001(****), K8.1, p<0.0001(****), and BCL2 p<0.05(*) in the setting of WT1 knockdown in ISLK BAC-16 with WT1 siRNA in comparison to a control siRNA using two-sided, unpaired student’s t-tests. …”

Identification of mutations that impair global folding. by Radhika Gopal (4692103)

“…Only one mutation T329A (red dot) resulted in markedly decreased V5 expression. …”

Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model by Christopher C. Marvin (1338228)

“…Mouse PK indicated that <b>6</b> is cleared 10-fold more rapidly than a first-generation GRM payload, resulting in 10-fold lower exposure and 3-fold decrease in Cmax. …”