Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2‑Aminoquinoline Inhibitors by Maris A. Cinelli (1309419)

“…Activity and selectivity are mediated by the binding of the cyano group to a new auxiliary pocket in nNOS. Potency was enhanced by methylation of the quinoline and by introduction of simple chiral moieties, resulting in a combination of hydrophobic and auxiliary pocket effects that yielded high (∼500-fold) n/e selectivity. …”

Accumulated immature APP in response to IDN5706 is degraded by Atg5-dependent autophagy. by Viviana A. Cavieres (500139)

Hypothesis 3: The mean difference between “Class 1” (a school attack happens within <i>k</i> kms. of a given school) and “Class 0” (no school attack happens within <i>k</i> kms. of... by Lirika Sola (21560710)

Inadequate riparian zone use directly decreases water quality of a low-order urban stream in southern Brazil by Enzo Luigi Crisigiovanni (8709570)

Responding Vγ9Vδ2-individuals decreases among HIV-infected patients who present lower Vγ9Vδ2 T-cell number than HD. by Rita Casetti (608635)

The stratified randomization process. by Zheng Sun (261083)

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Flow chart of study design. by Zheng Sun (261083)

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Ignition-type moxibustion device. by Zheng Sun (261083)

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IMQ-treated K14 mice had more stable skin inflammation. by Xuguo Wang (839264)

P-values for each factor in the full multiple regression models of volume, cross-sectional area (CSA), width, depth, Euclidean distance from the template (EDT), and phase shift rel... by Drew A. Anderson (14197446)

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Minimal dataset. by Drew A. Anderson (14197446)

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Effects of FE and RUD wrist postures on carpal tunnel length. by Drew A. Anderson (14197446)

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Carpal tunnel cross-sections used to calculate morphology metrics. by Drew A. Anderson (14197446)

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Effects of FE and RUD wrist postures on carpal tunnel volume distribution by quartile. by Drew A. Anderson (14197446)

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<i>Bahd1</i>-knockout mice display decreased weight and fat mass and lower cholesterol, glucose and leptin levels. by Goran Lakisic (2551717)

<strong>Figure 2 Manipulation of actin filament dynamics does not impact the decrease in the ATP/ADP ratio or ATP level induced by blockade of ATP production in either growth cones... by Sabrina Holland (16557051)

Transgenic <i>Eμ-V_H-OBF1</i> mice are immunodeficient due to decreased numbers of follicular B cells. by Alain Bordon (57422)

Pig growth over the course of the experiment. by James H. Bishop (2182486)

Effect of DFATs implantation on the inhibition of atrophy in the atrophic vocal fold muscle. by Ikuo Mikoshiba (9312007)

Probability of neutropenic-related event based on cycle 1 nadir ANC and average hemoglobin decrease at each sample by Edgardo Rivera (55591)