Reaction force vs. 5 µm displacement of the indenter. by Shreyas S. Rao (170163)

“…<p>Insert illustrates a decrease in stiffness with increasing Matrigel height due to a 5 µm indenter displacement. …”

Disruption of the viral cyclin has no effect on the frequency of viral genome positive cells yet results in a reduced frequency of LANA::βla+ cells. by Brian F. Niemeyer (11707995)

ADAR1 binding affinity at inferred A-to-I RNA editing candidate sites. by Xinxin Peng (219357)

Functional validation of a miRNA-34a-TREM2–3’UTR interaction. by Surjyadipta Bhattacharjee (3181674)

“…<p><b>(A)</b> ribonucleotide sequence of the 299 nt TREM2-mRNA-3’-UTR is shown in the 5’-3’ direction; the 22 nt miRNA-34a-TREM2 3’UTR complementarity-interaction region is indicated by a black underline and the 8 nt TREM2-mRNA-3’-UTR seed sequence <b>5’-ACACUGCU-3’</b> is overlaid in yellow; a single arrowhead indicates the 5’ end of a poly A+ tail in the TREM2 mRNA (22 ‘A’ nt shown; the length of this poly A+ tail is variable); TREM2 mRNA sequence derived from NM_018965; TREM2 transcript is the major X1 variant (see also <a href="http://switchdb.switchgeargenomics.com/productinfo/id_801321/" target="_blank">http://switchdb.switchgeargenomics.com/productinfo/id_801321/</a>) (<b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.g003" target="_blank">Fig 3</a></b>); <b>(B)</b> TREM2-mRNA-3’UTR expression vector luciferase reporter assay (pLightSwitch-3’UTR; Cat#S801178; Switchgear Genomics, Palo Alto CA); in this vector, the entire 299 nucleotide TREM2 3’UTR was ligated into the unique Nhe1-Xho1 site; <b>(C)</b> control C8B4 murine microglial cells, 1 week in culture; phase contrast bright field microscopy 20x; C8B4 cells transfected with the TREM2-mRNA-3’UTR expression vector luciferase reporter were treated exogenously with miRNA-34a, a scrambled control miRNA-34a (miRNA-sc) or control miRNA-183; see references and text for further details [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.ref018" target="_blank">18</a>,<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.ref019" target="_blank">19</a>]; <b>(D)</b> compared to control, C8B4 cells transfected with a scrambled (<b>sc</b>) control pLightSwitch-3’UTR vector, the TREM2-mRNA-3‘UTR vector exhibited decreased luciferase signal to a mean of 0.16-fold of controls in the presence of miRNA-34a; this same vector exhibited no change in the presence of the control miRNA-34a-sc or miRNA-183; for each experiment (using different batches of MG cells) a control luciferase signal was generated and included separate appropriate controls with each analysis; in addition a control vector β-actin-3’UTR showed no significant effects on the relative luciferase signal yield after treatment with either miRNA-183 or miRNA-34a (data not shown); dashed horizontal line set to 1.0 for ease of comparison; N = 5; *<i>p</i><0.001 (ANOVA). …”

Interventions for Psychological Stress in Pregnant African American Women: A Scoping Review by Taleah A. Frazier (22423294)

Additional <i>Setd5</i> behavioural controls. by Laura E. Burnett (18794525)

“…<b>(A</b>) Average speed during prestimulus exploration (<i>Setd5</i>^+/+, 7.50 cm s⁻¹; <i>Setd5</i>^+/−, 6.65 cm s⁻¹, <i>P</i> = 0.151). …”

Model comparison for different theories for the mouse germline bottleneck. by David M. Edwards (10692265)

Determination of 4.5SI RNA half-life. by Anastasia P. Koval (137050)

“…<p>(<b>A</b>) Northern hybridization of 4.5SI RNA and 5S rRNA in total RNA isolated from KAC cells exposed to actinomycin D for different time periods. …”

The influence of positional release therapy on the myofascial tension of the upper trapezius muscle by Francisco José Saavedra (4904293)

“…A significant decrease in painful symptoms from 5.3 ± 1.9 to 2.8 ± 1.8 (p < 0.001) was observed after treatment. …”

Metabolites that classify AggE vs. Ctrl mice at both acute and chronic time points. by Aarti Gautam (307419)

“…<p>MDA—‘mean decrease accuracy’ from random forests analysis</p><p>FC—fold change</p><p>*metabolites derived from gut microbiota</p><p>Metabolites that classify AggE vs. …”

JHMV replicates poorly in the brains of IFN-γ and IFN-γR null mice. by Catherine M. Kerr (21492574)

Heatmap of the members of the Wnt clusters identified by the five methods. by Mary-Lee Dequéant (271208)

bpV(pic) reduces neuronal autophagosome aggregation. by Chandler L. Walker (188845)

“…<p>Vehicle-treated rats exhibited dense intracellular LC3-positive autophagosome aggregation in neurons (arrows). Treatment with bpV promoted a decrease in neuronal autophagosome clustering. …”

Examples of approximations of RFR magnitude dependence on time by exponents. by Vladimir V. Popov (5563067)

Gating strategy for immune cells. by Catherine M. Kerr (21492574)

“…We’ve shown that a JHMV Mac1-mutant virus, N1347A, has decreased replication and disease in the brains of mice. …”

RNA Seq Results. by Catherine M. Kerr (21492574)

“…We’ve shown that a JHMV Mac1-mutant virus, N1347A, has decreased replication and disease in the brains of mice. …”

JHMV survival and weight loss is not altered IFN-γ null mice. by Catherine M. Kerr (21492574)

RFR waveforms and Gabor-filtered envelopes during the 25 ms after stimulus level changes. by Vladimir V. Popov (5563067)

Overview of the experimental procedure. by Jennifer Gioda (17951785)

Chinese Herbal Medicine for Aspirin Resistance: A Systematic Review and Meta-Analysis by Hanyu Chen (2735152)

“…And one trial showed that CHM plus aspirin could decrease the National Institutes of Health Stroke Scale (NHISS) score (P<0.05) and increase the Barthel Index (BI) score (P<0.05). 4 trials stated that there were no adverse effects occurred in intervention group, and analysis showed significant difference of CHM or CHM plus aspirin in reducing the occurrence of adverse events (FE, RR = 0.22, 95%CI[0.13, 0.39], P<0.00001). 5 trials claimed that the CHM monotherapy and CHM adjunctive therapy for AR did not add the risk of bleeding (FE, RR = 0.50, 95%CI[0.20, 1.22], P = 0.13>0.05).…”