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Ivermectin as an adjuvant to anti-epileptic treatment in persons with onchocerciasis-associated epilepsy: A randomized proof-of-concept clinical trial
Published 2020“…<div><p>Introduction</p><p>Recent findings from onchocerciasis-endemic foci uphold that increasing ivermectin coverage reduces the epilepsy incidence, and anecdotal evidence suggests seizure frequency reduction in persons with onchocerciasis-associated epilepsy, when treated with ivermectin. We conducted a randomized clinical trial to assess whether ivermectin treatment decreases seizure frequency.…”
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2‑Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2)
Published 2023“…To develop more potent compounds, we initiated a structure–activity relationship study that identified 2-aminobenzoxazole as a viable scaffold. …”
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Hydrogen peroxide scavenging by the <i>Aedes aegypti</i> peritrophic matrix.
Published 2023Subjects: -
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Dietary Restriction Induces Gluconeogenic Gene <i>pck-2</i> Expression via DAF-16, and <i>pck-2</i> Expression is Needed for DR-associated Healthspan Benefits.
Published 2020“…<p>(A) Representative wild-type animals expressing a GFP transcriptional reporter for <i>pck-2</i> (<i>pck-2</i> promoter GFP fusion, lacking <i>pck-2</i> coding sequences) under <i>ad libitum</i> (AL) or dietary restricted (DR) conditions, day 4 of life. …”
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