Showing 81 - 100 results of 11,107 for search '(( e point decrease ) OR ((( 50 mg decrease ) OR ( 50 ((we decrease) OR (nn decrease)) ))))', query time: 0.51s Refine Results
  1. 81
  2. 82
  3. 83
  4. 84
  5. 85
  6. 86
  7. 87

    S3 File - by Andrei Rajkovic (10965915)

    Published 2023
    Subjects:
  8. 88
  9. 89
  10. 90
  11. 91
  12. 92
  13. 93
  14. 94
  15. 95

    Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3‑Oxo-3,4-dihydro‑2<i>H</i>‑ben... by Shuhei Ikeda (2380180)

    Published 2021
    “…Optimization of the left hand side afforded <b>4f</b> as a promising reversible MAGL inhibitor, which showed potent in vitro MAGL inhibitory activity (IC<sub>50</sub> 6.2 nM), good oral absorption, blood–brain barrier penetration, and significant pharmacodynamic changes (2-arachidonoylglycerol increase and arachidonic acid decrease) at 0.3–10 mg/kg, po. in mice.…”
  16. 96
  17. 97
  18. 98
  19. 99
  20. 100