Fast MacMillan’s Imidazolidinone-Catalyzed Enantioselective Synthesis of Polyfunctionalized 4‑Isoxazoline Scaffolds by Dario Corbisiero (6894959)

“…The enantioselective 1,3-dipolar cycloaddition of nitrones and arylpropionaldehydes to generate highly functionalized scaffolds for application in drug discovery was herein investigated. The use of a second-generation MacMillan catalyst as hydrochloride salt consistently accelerated the reaction speed, allowing a decrease in the reaction time up to >100 times, still affording 4-isoxazolines with good to excellent enantiomeric ratios at room temperature. …”

Interaction of Cro with nAChR of <i>T</i>. <i>californica</i> electric organ, human neuronal α7 nAChR and AChBP. by Catherine A. Vulfius (676708)

MOLECULAR FEATURES OF TRIPLE NEGATIVE BREAST CANCER STEM CELLS: A GENE EXPRESSION PROFILING ANALYSIS OF MDA-MB-231 CELLS by Hourani, Shireen Bayan

“…Finally, CSCs expressed a 100% higher ROS+ than TNBC. TNBC CSCs are quiescent, with highly functional DNA damage repair mechanism. …”
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A novel SNP of <i>MYO1A</i> gene associated with heat-tolerance in Chinese cattle by Yanhong Cao (428443)

“…Further analysis showed that frequency of wild allele A decreased gradually from northern cattle to southern cattle, whereas frequency of mutant type allele G showed the opposite pattern, which was consistent with the distribution of various climatic conditions of China. …”

Polymorphic Variants of SCN1A and EPHX1 Influence Plasma Carbamazepine Concentration, Metabolism and Pharmacoresistance in a Population of Kosovar Albanian Epileptic Patients by Armond Daci (824294)

“…</p><p>Materials & Methods</p><p>Five SNPs in two candidate genes influencing CBZ transport and metabolism, namely ABCB1 or EPHX1, and CBZ response SCN1A (sodium channel) were genotyped in 145 epileptic patients treated with CBZ as monotherapy and 100 age and sex matched healthy controls. …”

pMCID depiction. by Martin M. Monti (9704273)

“…(Note: While not depicted, the calculation also includes “net” 1-point changes; e.g., where a 1-point decrease is observed in one subscale and a 2-point increase is observed on a different subscale; see methods for full detail).…”

DataSheet_1_Distinct effects of rosuvastatin and rosuvastatin/ezetimibe on senescence markers of CD8+ T cells in patients with type 2 diabetes mellitus: a randomized controlled tri... by Sang-Hyeon Ju (15373114)

“…Objectives<p>Chronic low-grade inflammation is widely recognized as a pathophysiological defect contributing to β-cell failure in type 2 diabetes mellitus (T2DM). …”

PCNA inhibitors inhibit HSV-1 infection. by Jessica E. Packard (16641690)

Prevalence of suicidal ideation in the Bt20+ cohort. by Massimiliano Orri (560000)

Combinatorial treatment delays MM growth in vivo. by Chengyu Wu (640314)

Data_Sheet_1_Copy Number Analyses Identified a Novel Gene: APOBEC3A Related to Lipid Metabolism in the Pathogenesis of Preeclampsia.DOCX by Nan Liu (1630)

“…Pregnant mice of the same model at the end of pregnancy showed changes related to preeclampsia-like symptoms, such as increases in sFlt-1 levels and sFlt-1/PLGF ratios in the placenta and decreases in fetal weight.</p>Conclusion<p>Our findings established a new link between genetics and lipid metabolism in the pathogenesis of preeclampsia and could contribute to a better understanding of the molecular mechanisms of preeclampsia.…”

Supplementary Material for: Skin Tests versus Serology: Specific IgE May Suffice for Diagnosis of Vespid Venom Allergy and Follow-Up of Allergen Immunotherapy by Hollstein M.M. (14790304)

“…In contrast, venom-specific IgG and IgG4 levels, and the minimal venom concentration required to induce a positive ICT result increased, while the venom wheal area standardized to 0.1 μg/mL venom application and specific IgE levels decreased over time. <b><i>Conclusion:</i></b> Wheal area evaluation did not provide additional information over specific IgE analysis. …”

Rescue of vitellogenic growth in <i>bmp15-/-</i> females by E2 treatments. by Yue Zhai (3141960)

Sucrose feeding increases the expression levels of antiviral genes in the digestive tract of the female <i>Ae</i>. <i>aegypti</i>. by Floriane Almire (8310183)

Adipogenic differentiation of hVSCs from VAT and SAT of subjects with different BMI and HOMA-IR index. by Adriana-Mariel Gentile (835446)

“…Gene expression was referred to differentiated lean-Low-IR samples, which were considered as 100%; <i>RPL13A</i> was used as reference gene. …”

RNLS distribution in human precursor and PDAC tissue. by Yasheen Gao (6090842)

Different ellipsoidal particles with De = 6.30 mm used in the discrete element simulations. by Yongfeng Zhu (7361045)

Evaluation of risk model. by Yajia Chen (20685780)

Data processing and predictive model construction. by Yajia Chen (20685780)

Measurements of HO-1 and dephosphorylated p38-MAPK concentrations in alveolar macrophages. by Ana Fernandez-Bustamante (766266)