Table 1_Targeting nail psoriasis: IL-17A inhibitors demonstrate site-specific superiority over IL-23 inhibitor in a 24-week dermoscopy-guided real-world cohort.docx by Xiamei Yan (21014921)

“…Objective<p>To compare the real-world clinical efficacy and safety of interleukin (IL)-17A inhibitors (secukinumab [SEC] and ixekizumab [IXE]) versus the IL-23 inhibitor guselkumab (GUS) in patients with nail psoriasis, with a focus on site-specific biologic therapeutic responses (nail matrix vs. nail bed) in a 24-week prospective observational cohort.…”

Hidden Markov model (HMM) design and fit to behavior. by R. Becket Ebitz (7841318)

Binding models with two binding sites: Independent binding and negative cooperativity leads to identical dose-response curves in equilibrium. by Federico Sevlever (8934533)

Change of colocalization of Sig1R-YFP and KDEL-mRFP caused by (+)-pentazocine. by Sergei Kopanchuk (6406085)

“…Scale bar = 1 μm. A time-dependent decrease in spot coupling was observed between Sig1R-YFP and KDEL-mRFP after activation of Sig1R with 100 nM (+)-pentazocine (middle image). …”

Table_1_Computational prediction and experimental validation of Salmonella Typhimurium SopE-mediated fine-tuning of autophagy in intestinal epithelial cells.xlsx by Amanda Demeter (5612528)

“…We also revealed that SopE might have a double role in the modulation of autophagy: Following initial increase of MAP1LC3B transcription triggered by Salmonella infection, subsequent decrease in MAP1LC3B transcription at 6h post-infection was SopE-dependent. …”

Behavior in baseline sessions. by R. Becket Ebitz (7841318)

The Ca²⁺/PKC/p115 signaling axis enables persistent RhoA signaling. by Jason Z. Zhang (9339291)

“…<p>(<b>A</b>) HeLa cells expressing various proteins and treated with various drugs to increase or decrease flux into the Ca²⁺/PKC/p115 signaling axis. …”

<i>C</i>. <i>sinensis</i> enhanced bile duct and liver injury through TLR2 pathway. by Yuru Wang (846969)

PXT3003 therapy acting on Pmp22 overexpression and downstream signalling in long-term at 12 weeks. by Thomas Prukop (6236186)

“…At the end of long-term observation, PXT3003 early short-term treatment restored the decreased p-AKT/AKT signalling in CMT1A rats (H; WT controls 1.00±0.17, CMT1A controls 0.38±0.08, CMT PXT3003-3 0.93±0.21) and dose-dependently corrected the disrupted ratio of p-AKT/AKT to p-MAPK/MAPK signalling towards the wildtype situation (I; CMT1A controls 0.30±0.08, CMT PXT3003-1 0.56±0.15, CMT PXT3003-2 0.85±0.13, CMT PXT3003-3 1.36±0.52), which is characterized by a higher relative amount of p-AKT versus p-MAPK. …”

IGF-1 downregulates MMP8 and reduces collagenase activity in cultured THP-1 macrophages. by Patricia Snarski (22305205)

Paradoxical Interaction between Ocular Activity, Perception, and Decision Confidence at the Threshold of Vision by Aaron Schurger (515033)

“…Our data analyses revealed an unexpected and counterintuitive interaction between the steadiness of fixation (prior to and during stimulation), perceptual decision making, and post-decision wagering: greater variability in gaze direction during fixation was associated with significantly increased visual-perceptual sensitivity, but significantly decreased reliability of confidence judgements. The latter effect could not be explained by a simple change in overall confidence (i.e. a criterion artifact), but rather was tied to a change in the degree to which high wagers predicted correct decisions (i.e. the sensitivity of the confidence judgement). …”

Attraction at a distance and repulsion at a shorter range is required for neural crest stream formation. by András Szabó (3034779)

“…Letters refer to related panels. Error bars on E and H: SEM. N = 20 simulations for each point on E, H, and I. …”

Colocalization of Sig1R-YFP in SK-OV-3 cells with the markers pmKate2-mito and KDEL-mRFP. by Sergei Kopanchuk (6406085)

Colocalization of Sig1R-YFP with immunostained ER and mitochondria on fixed and permeabilized SK-OV-3 cells. by Sergei Kopanchuk (6406085)

Isothermal titration calorimetry (ITC). by Lukas Martin (747245)

VEGF mutant villi demonstrated increased angiogenesis and vascular permeability. by Christopher R. Schlieve (3179439)

Hazard ratios of cardiovascular outcomes in AMORIS and WOLF/60YO, with 95% confidence intervals, for quintiles of the apoB/apoA-1 ratio. by Göran Walldius (286838)

The spot coupling analysis. by Sergei Kopanchuk (6406085)

Representative zoomed SRRF images of the expression of Sig1R-YFP together with intracellular markers. by Sergei Kopanchuk (6406085)

Emergent streams at different neural crest adhesion strengths. by András Szabó (3034779)