In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels by Jonathan J. Cherry (501180)

“…Treatment of cells caused modest and transient <i>SMN2</i> mRNA increases with either no change or a decrease in <i>SMNΔ7</i> and no change in <i>SMN1</i> transcripts or SMN protein. …”

Image 2_Profiling of fecal analytes as a potential biomarker in rheumatoid arthritis.tif by Zhiyi Wang (328693)

“…</p>Results<p>NA and D2T patients demonstrated marked elevations in fecal pro-inflammatory cytokines compared to RE and HC groups, including IL-6, Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), IL-1 beta (IL-1β), Interferon-gamma (INF-γ), IL-23, Tumor Necrosis Factor-Alpha (TNF-α), IL-21, IL-17A/F, and IL-22. Fecal zonulin and plasma HIF-2α were significantly elevated in both NA and D2T groups, whereas fecal D-lactate showed a pronounced decrease in the NA and D2T groups. …”

Table 1_Profiling of fecal analytes as a potential biomarker in rheumatoid arthritis.docx by Zhiyi Wang (328693)

“…</p>Results<p>NA and D2T patients demonstrated marked elevations in fecal pro-inflammatory cytokines compared to RE and HC groups, including IL-6, Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), IL-1 beta (IL-1β), Interferon-gamma (INF-γ), IL-23, Tumor Necrosis Factor-Alpha (TNF-α), IL-21, IL-17A/F, and IL-22. Fecal zonulin and plasma HIF-2α were significantly elevated in both NA and D2T groups, whereas fecal D-lactate showed a pronounced decrease in the NA and D2T groups. …”

Image 3_Profiling of fecal analytes as a potential biomarker in rheumatoid arthritis.tif by Zhiyi Wang (328693)

“…</p>Results<p>NA and D2T patients demonstrated marked elevations in fecal pro-inflammatory cytokines compared to RE and HC groups, including IL-6, Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), IL-1 beta (IL-1β), Interferon-gamma (INF-γ), IL-23, Tumor Necrosis Factor-Alpha (TNF-α), IL-21, IL-17A/F, and IL-22. Fecal zonulin and plasma HIF-2α were significantly elevated in both NA and D2T groups, whereas fecal D-lactate showed a pronounced decrease in the NA and D2T groups. …”

Image 4_Profiling of fecal analytes as a potential biomarker in rheumatoid arthritis.tif by Zhiyi Wang (328693)

“…</p>Results<p>NA and D2T patients demonstrated marked elevations in fecal pro-inflammatory cytokines compared to RE and HC groups, including IL-6, Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), IL-1 beta (IL-1β), Interferon-gamma (INF-γ), IL-23, Tumor Necrosis Factor-Alpha (TNF-α), IL-21, IL-17A/F, and IL-22. Fecal zonulin and plasma HIF-2α were significantly elevated in both NA and D2T groups, whereas fecal D-lactate showed a pronounced decrease in the NA and D2T groups. …”

Image 1_Profiling of fecal analytes as a potential biomarker in rheumatoid arthritis.tif by Zhiyi Wang (328693)

“…</p>Results<p>NA and D2T patients demonstrated marked elevations in fecal pro-inflammatory cytokines compared to RE and HC groups, including IL-6, Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), IL-1 beta (IL-1β), Interferon-gamma (INF-γ), IL-23, Tumor Necrosis Factor-Alpha (TNF-α), IL-21, IL-17A/F, and IL-22. Fecal zonulin and plasma HIF-2α were significantly elevated in both NA and D2T groups, whereas fecal D-lactate showed a pronounced decrease in the NA and D2T groups. …”

A Pilot Randomized Placebo Controlled Trial of Electroacupuncture for Women with Pure Stress Urinary Incontinence by Huanfang Xu (2558446)

“…The differences between groups in the decrease from baseline of 72-hour IEF became statistically significant at week 30 with a median decrease of 3.25 g (IQR: 1.25–5.69) in the EA group, and a median decrease of 1.00 g (IQR: -0.69–+2.88) in the sham EA group (p = 0.01). …”

CA1 PNs that will become part of a representation display higher structural postsynaptic stability. by Tim P. Castello-Waldow (9596799)

“…(A–F) Data points are the number of spines that turned over (A, D), were gained (B, E), or survived (C, F), normalized to day 1 or 8. …”

Further Studies on the Latitudinal and Temporal Trends of Persistent Organic Pollutants in Norwegian and U.K. Background Air by Foday M. Jaward (2230999)

“…Data are presented for PBDEs, PCBs, and selected organochlorine compounds, measured at background locations by passive air samplers (semipermeable membrane devices, SPMDs) along a latitudinal transect from the south of the U.K. to the north of Norway during 2000−2002. …”

Prognostic indicators and survival rates in vulvar cancer: insights from a retrospective study by Tharinee Rahong (21020147)

“…Additionally, a tumour size exceeding 4 cm in diameter was significantly linked with decreased OS (<i>p</i> = .001). …”

The SimpliciT1 Study: A Randomized, Double-Blind, Placebo-Controlled Phase 1b/2 Adaptive Study of TTP399, a Hepatoselective Glucokinase Activator, for Adjunctive Treatment of Type... by Klara R. Klein (1973449)

Competition with TESA and trypomastigote protein extract demonstrates that Apt-L44 binds to a parasite biomarker. by Rana Nagarkatti (90297)

“…(<b>A</b>) In the presence of TESA, biotinylated aptamer is sequestered by its target and cannot interact with the target present in the coated plasma, causing a decrease in signal levels represented by % inhibition. …”

Inhibition of Class A β‑Lactamase (TEM-1) by Narrow Fractions of Humic Substances by Tatyana A. Mikhnevich (11401701)

A comparison of viral dsRNAs and poly(I:C) for activation of TLR3. by Yvonne Lai (199718)

“…The data shown is the mean ± SEM, with the number of assays in parentheses: pIC (n = 23), Reovirus dsRNA (ReoV, n = 9), Reovirus S4 dsRNA (S4; n = 28), BPEV (n = 6), JFH1 (n = 3). …”

An Examination of a Novel Weight Loss Supplement on Anthropometry and Indices of Cardiovascular Disease Risk by Ryan J. Sowinski (9280085)

A non-equilibrium slurry model of the F-layer above the inner core boundary by Andrew Walker (411843)

Supplementary Material for: Peripheral Retinal Imaging Biomarkers for Alzheimer’s Disease: A Pilot Study by Csincsik L. (5063666)

Regulation by a shared sRNA synchronizes the temporal induction of mRNA expression. by Jörn Matthias Schmiedel (141779)

“…The heatmaps show simulation results for a regulatory scenario where a coordinate, step-like increase (C) or decrease (panel D) in both mRNA synthesis rates is accompanied by a step-like change in the sRNA synthesis rate in the opposite direction; this counter-regulation assumption was necessary to eliminate delay phases, and to obtain the same steady states in sRNA and sRNA-less systems. …”

Effects of varying RU486 exposure time on Aβ42 levels and toxicity. by Iain Rogers (152860)

“…(B) Soluble and insoluble Arctic Aβ42 was fractionated (see methods) and measured by ELISA at the indicated time-points (n = 3). …”

<i>Bs</i>Fra alters the H/D exchange of <i>Bs</i>SufS and <i>Bs</i>SufU upon binding the <i>Bs</i>SufS/<i>Bs</i>SufU complex. by Bastian Blauenburg (715579)

“…Changes in <b>(F)</b> the SufU α5-helix and <b>(G)</b> the Cys41-loop as a function of deuterium uptake over time. …”