Donor Properties of the Vanadyl Ion:  Reactions of Vanadyl Salicylaldimine β-Ketimine and Acetylacetonato Complexes with Groups 14 and 15 Lewis Acids by B. Cashin (2964237)

“…Coordination of water trans to a vanadyl oxygen that is involved in a donor bond to tin or lead has little or no effect on the vanadyl bond length but results in a marked movement of vanadium toward the basal plane and a decrease of the VOD (D = Sn or Pb) bond angle by as much as 13°, the latter reflecting a loss of multiple bond character of the vanadyl bond. …”

Blood flow to the stomach during controlled hypotension (CH). by Lele Zhang (388913)

“…TENS significantly prevented the decreased perfusion to the stomach. During the maintenance and MAP restoration stages (T₅–T₁₀), gastric blood flow in the CH group decreased significantly regardless of the cessation of SNP infusion. …”

NUCB2/nesfatin-1 Is Associated with Elevated Levels of Anxiety in Anorexia Nervosa by Tobias Hofmann (327174)

“…The study population was divided in patients with low anxiety (n = 32, GAD-7 scores, mean±SD, 7.5±3.3) and high anxiety (n = 32, 16.0±3.0, <i>p</i><0.001). …”

<i>Sting</i>^<i>Gt/Gt</i> mice display improve clearance of <i>S</i>. <i>aureus</i> following cutaneous challenge. by Philip O. Scumpia (4246900)

“…(B) Left panel shows Total Flux over 5 minutes, and Right panel shows Mean Radiance (Photons/second). * denotes p<0.05 by one way ANOVA with Tukey’s test for <i>Sting</i>^<i>Gt/Gt</i> mice when compared to WT mice at each time point and represents an n = 8 mice over two separate experiments. ** denotes p<0.05 by one-way ANOVA with Tukey’s test at each time point for <i>Myd88</i>^-/- mice when compared to WT mice at each time point and represents an n = 5 for <i>Myd88</i>^-/- compared to n = 8 WT mice. …”

Increased BMP/TGFB signaling pathway activity in <i>Rx > cre Myrf</i>^<i>fl/fl</i> mutants. by Michelle L. Brinkmeier (18709048)

“…(C-<i>Myrf</i>^<i>fl/fl</i>; M-<i>Rx > cre Myrf</i>^<i>fl/fl</i>) (B) VlnPlot representation of transcript levels of <i>Wfikkn2</i>, <i>Tgfb2,</i> and <i>Id3</i> in theRPE cluster highlighting a decrease in the pathway inhibitor, <i>Wfikkn2</i> and increases in <i>Tgfb2</i> and <i>Id3</i>. …”

6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway by Yasuomi Urano (685567)

“…We moreover observed that 6-OHDA-derived electrophilic quinone induced oxidative stress as indicated by a decrease in glutathione levels, and that this was suppressed by pretreatment with antioxidant NAC. …”

Image1_Sodium–Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK–mTOR Signaling Pathway–Mediated Autophagy.JPE... by Changzhen Ren (10649432)

“…We aimed to determine whether empagliflozin (EMPA), an SGLT2 inhibitor, has a protective role against sunitinib (SNT)-induced cardiac dysfunction in a mouse model.…”

Image4_Sodium–Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK–mTOR Signaling Pathway–Mediated Autophagy.JPE... by Changzhen Ren (10649432)

“…We aimed to determine whether empagliflozin (EMPA), an SGLT2 inhibitor, has a protective role against sunitinib (SNT)-induced cardiac dysfunction in a mouse model.…”

Image2_Sodium–Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK–mTOR Signaling Pathway–Mediated Autophagy.JPE... by Changzhen Ren (10649432)

“…We aimed to determine whether empagliflozin (EMPA), an SGLT2 inhibitor, has a protective role against sunitinib (SNT)-induced cardiac dysfunction in a mouse model.…”

DataSheet1_Sodium–Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK–mTOR Signaling Pathway–Mediated Autophagy... by Changzhen Ren (10649432)

“…We aimed to determine whether empagliflozin (EMPA), an SGLT2 inhibitor, has a protective role against sunitinib (SNT)-induced cardiac dysfunction in a mouse model.…”

Social Determinants of the Lung Cancer Care Continuum by Cherie P Erkmen (11576761)

“…For example, smoking increases the risk of getting lung cancer by 10x, and those in lower income brackets and of lower education level are 2 to 3 times more likely to be smokers.2,3 Though annual lung cancer screening can decrease mortality4, minority and underserved populations are less likely to participate in screening and less likely to follow-up after a baseline scan.5-7 Low participation and compliance with lung cancer screening creates a missed opportunity to reduce mortality among these populations, thus exacerbating lung cancer disparity.7 Even when diagnosed, African Americans and those in the lowest socioeconomic quartile have significantly lower survival from lung cancer compared to others.8,9 This work details how disparities along the continuum of lung cancer care result in higher and morbidity.…”

Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Clinical and Hypoxemic Childhood Pneumonia over Three Years in Central Malawi: An Observational Study by Eric D. McCollum (252799)

“…At 76% three-dose PCV13 coverage, versus 0%, the time-series model showed a non-significant increase in total cases (+47%, 95% CI: -13%, +149%, p = 0.154); fast breathing cases increased 135% (+39%, +297%, p = 0.001), however, hypoxemia fell 47% (-5%, -70%, p = 0.031) and hospital deaths decreased 36% (-1%, -58%, p = 0.047) in children <5 years. …”

Image3_Sodium–Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK–mTOR Signaling Pathway–Mediated Autophagy.JPE... by Changzhen Ren (10649432)

“…We aimed to determine whether empagliflozin (EMPA), an SGLT2 inhibitor, has a protective role against sunitinib (SNT)-induced cardiac dysfunction in a mouse model.…”

Mid-Gestational Gene Expression Profile in Placenta and Link to Pregnancy Complications by Liis Uusküla (121629)

“…TaqMan RT-qPCR analysis (<em>n</em> = 43; gestational weeks 5–41) confirmed a significant (ANOVA and t-test, FDR <em>P</em><0.05) mid-gestational peak of placental gene expression for <em>BMP5</em>, <em>CCNG2</em>, <em>CDH11</em>, <em>FST</em>, <em>GATM</em>, <em>GPR183</em>, <em>ITGBL1</em>, <em>PLAGL1</em>, <em>SLC16A10</em> and <em>STC1</em>, followed by sharp decrease in mRNA levels at term (t-test, FDR <em>P</em><0.05). …”

Genetic interaction between <i>mec-12(gm379)</i> and <i>unc-104</i>. by Jiun-Min Hsu (660083)

“…Quantifications are mean ± S.E.M. Scale bars  = 5 µm. *, <i>p</i><0.05; **, <i>p</i><0.001; ***, <i>p</i><0.0001, Mann-Whitney U test.…”

Inhibition of SDF-1 signaling alleviates chronic skin inflammation and inhibits leukocyte migration towards SDF. by Silvana Zgraggen (546104)

“…<p>(A) On day -5, hemizygous K14 VEGF-A transgenic mice (n = 14) were sensitized with 2% oxazolone and challenged on day 0 with 1% oxazolone on the ears. …”

Pheromone-responding ORNs and MGC calcium responses in virgin and mated males. by Nina Deisig (178118)

“…Solvent (sol) refers to pooled data of stimulations with hexane and mineral oil. Phe-ORNs show a decreased firing frequency to the pheromone by the addition of heptanal at all doses tested. …”

<i>E2f7/8</i> are essential for polyploidization in the pancreas. by Ramadhan B. Matondo (4763097)

“…<p>(A) Hematoxylin & Eosin staining (400x magnification), top panel and DAPI (630x magnification, 1.5x zoom factor for exocrine, and 630x, 3x zoom factor for endocrine pancreas) lower panel, showing decreased nuclear sizes in <i>78</i>^{<i>∆/∆</i>} compared to control <i>78</i>^<i>f/f</i> mice injected with tamoxifen at day 2 after birth and analysed at the age of 22 weeks. …”

Characterization of Heterogeneity and Dynamics of Lysis of Single Bacillus subtilis Cells upon Prophage Induction During Spore Germination, Outgrowth, and Vegetative Growth Using R... by Mei-yan Wu (9921201)

“…Major findings of this work are as follows: (i) After addition of xylose to trigger prophage induction, the intensities of Raman spectral bands associated with nucleic acids of single cells in induced cultures gradually fell to zero, in contrast to the much smaller changes in protein band intensities and no changes in nucleic acid bands in uninduced cultures; (ii) the nucleic acid band intensities from an individual induced cell exhibited a rapid decrease, following a long lag period; (iii) after the addition of nutrient-rich medium with xylose, single spores underwent a long period (228 ± 41.4 min) for germination, outgrowth, and vegetative growth, followed by a short period of cell burst in 1.5 ± 0.8 min at a cell length of 8.2 ± 5.5 μm; (iv) the latent time (<i>T</i>_latent) between the addition of xylose and the start of cell burst was heterogeneous in cell populations; however, the period (Δ<i>T</i>_burst) from the latent time to the completion of cell lysis was quite small; (v) in a poor medium with l-alanine alone, addition of xylose caused prophage induction following spore germination but with longer <i>T</i>_latent and Δ<i>T</i>_burst times and without cell elongation; (vi) spontaneous prophage induction and lysis of individual cells from spores in a minimal nutrient medium were observed without xylose addition, and cell length prior to cell lysis was ∼4.1 μm, but spontaneous prophage induction was not observed in a rich medium; (vii) in a rich medium, addition of xylose at a time well after spore germination and outgrowth significantly shortened the average <i>T</i>_latent time. …”

Characterization of Heterogeneity and Dynamics of Lysis of Single Bacillus subtilis Cells upon Prophage Induction During Spore Germination, Outgrowth, and Vegetative Growth Using R... by Mei-yan Wu (9921201)

“…Major findings of this work are as follows: (i) After addition of xylose to trigger prophage induction, the intensities of Raman spectral bands associated with nucleic acids of single cells in induced cultures gradually fell to zero, in contrast to the much smaller changes in protein band intensities and no changes in nucleic acid bands in uninduced cultures; (ii) the nucleic acid band intensities from an individual induced cell exhibited a rapid decrease, following a long lag period; (iii) after the addition of nutrient-rich medium with xylose, single spores underwent a long period (228 ± 41.4 min) for germination, outgrowth, and vegetative growth, followed by a short period of cell burst in 1.5 ± 0.8 min at a cell length of 8.2 ± 5.5 μm; (iv) the latent time (<i>T</i>_latent) between the addition of xylose and the start of cell burst was heterogeneous in cell populations; however, the period (Δ<i>T</i>_burst) from the latent time to the completion of cell lysis was quite small; (v) in a poor medium with l-alanine alone, addition of xylose caused prophage induction following spore germination but with longer <i>T</i>_latent and Δ<i>T</i>_burst times and without cell elongation; (vi) spontaneous prophage induction and lysis of individual cells from spores in a minimal nutrient medium were observed without xylose addition, and cell length prior to cell lysis was ∼4.1 μm, but spontaneous prophage induction was not observed in a rich medium; (vii) in a rich medium, addition of xylose at a time well after spore germination and outgrowth significantly shortened the average <i>T</i>_latent time. …”