Efficacy and safety of saxagliptin in combination with insulin in Japanese patients with type 2 diabetes mellitus: a 16-week double-blind randomized controlled trial with a 36-week... by Takashi Kadowaki (35402)

“…</p> <p><b>Research design and methods</b>: We randomized 240 patients with type 2 diabetes mellitus on insulin monotherapy to 5-mg saxagliptin or placebo as add-on therapy for a 16-week, double-blind period. …”

Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively... by Panchanan Maiti (1459852)

“…Due to the poor solubility and limited bioavailability, these compounds have limited efficacy for treating cancer. However, use of a formulation of curcumin with higher bioavailability or combining it with berberine as a co-treatment may be proving to be more efficacious against cancer. …”

Reduced RNA expression of the <i>FMR1</i> gene in women with low (CGG_n<26) repeats by Qi Wang (22418)

“…The main outcome measure was RNA expression in human luteinized granulosa cells of 5 groups of FMRP isoforms. The relative expression of FMR1 RNA in human luteinized granulosa cells was measured by real-time PCR and a possible association with CGG_n was explored. …”

Predicted performance of a control program administered to dogs on arrival in US animal shelters. by Benjamin D. Dalziel (650353)

“…(<b>B</b>) Decreasing control efficacy to 75% can still achieve eradication in isolated shelters (blue region, solid line), however shelters that transfer dogs amongst themselves at the observed mean rate of τ = 0.1 would preserve CIV in a few shelters despite the vaccination program (red region, dashed line). …”

Optimal Dose and Method of Administration of Intravenous Insulin in the Management of Emergency Hyperkalemia: A Systematic Review by Ziv Harel (2696983)

“…There was no statistically significant difference in mean decrease in serum potassium (K⁺) concentration at 60 minutes between studies in which insulin was administered as an infusion of 20 units over 60 minutes and studies in which 10 units of insulin was administered as a bolus (0.79±0.25 mmol/L versus 0.78±0.25 mmol/L, <i>P</i> = 0.98) or studies in which 10 units of insulin was administered as an infusion (0.79±0.25 mmol/L versus 0.39±0.09 mmol/L, <i>P</i> = 0.1). …”

Fetal and maternal Doppler adaptation to maternal exercise during pregnancy: a randomized controlled trial by Irene Fernández-Buhigas (14763235)

“…The evolution of the UA PI <i>z</i>-score during the pregnancy was different in the two study groups, with a higher <i>z</i>-score in the exercise group at 20 weeks and a subsequent decrease until delivery while in the control group it remained stable at around zero.…”

An idealized view of the opportunity provided by a comparative and integrated oncology drug development path. by Ira Gordon (369869)

“…Factoring in additional costs for comparative studies with this approach of US$150,000 for studies conducted in the preclinical setting, US$250,000 for studies conducted before or during Phases I–II human trials and US$1 million for studies conducted before Phases II–III studies, the total cost of development is estimated at US$2.07 billion. The result may be a decrease in average clinical trial costs per approved drug from US$290 million to US$173 million <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1000161#pmed.1000161-Adams1" target="_blank">[5]</a>.…”

The changing trends of <i>f</i>_<i>i</i>, <i>i</i> ∈ {1, 2, 3, 4} with <i>v</i> for the Moran process (first row) and the Wright-Fisher process (second row) when <i>u</i>... by Yanling Zhang (6561)

“…For all <i>r</i>, The curve of <i>f</i>₄ with <i>v</i> (fourth column) has an increasing trend with a small perturbation near <i>v</i> = 0.01. …”

Data_Sheet_1_Expression of vitamin D receptor, CYP24A1, and CYP27B1 in normal and inflamed canine pancreases.DOCX by Dohee Lee (432106)

“…This study showed that VDR expression decreased in inflamed pancreases and demonstrated CYP24A1 and CYP27B1 expression in the canine pancreas for the first time. …”

Core–Shell {Mn₇⊂(Mn,Cd)₁₂} Assembled from Core {Mn₇} Disc by Ling-Yu Guo (3068232)

“…HR-ESI-MS was even more precise by revealing three prominent molecular species, Mn₁₃Cd₆, Mn₁₄Cd₅ and Mn₁₅Cd₄, having a distribution of metals. …”

Temperature-Induced Phase Transitions of Vivianite: In Situ Analysis of a Redox-Driven Crystallization by Alice Paskin (10017280)

Diabetes, Drug Treatment and Mortality in COVID-19: A Multinational Retrospective Cohort Study by Jennifer E. Nyland (11412878)

“…Use of DPP-4 inhibitors was associated with a reduction in respiratory complications (24.0% vs 29.2%; RR, 0.82 [95% CI, 0.74-0.90]; <i>P</i> <.001), and continued use of DPP-4 inhibitors after hospitalization was associated with a decrease in mortality compared with those who discontinued use (9% vs 19%; RR, 0.45 [95% CI, 0.28-0.72]; <i>P</i> <.001). …”

Application of product development tools in equipment design for a technology-based small business by Felipe Mello Pierobom (10396580)

High mRNA expression of <i>Slc6a15</i> in CNS. by Maria G. A. Hägglund (386708)

RPIA regulates colon cell proliferation through β-catenin expression in HCT116 cells. by Yu-Ting Chou (447778)

“…<i>AXIN2</i>, <i>Axis inhibition protein 2</i>; <i>CCND1</i>, <i>Cyclin D1</i>; <i>CCNE2</i>, <i>Cyclin E2</i>; <i>CTNNB1</i>, <i>CATENIN BETA 1</i>; pcDNA, pcDNA3 vector control; qPCR, quantitative PCR; RPIA, ribose-5-phosphate isomerase A; si-NC, negative control small interfering RNA; si-RPIA, RPIA small interfering RNA; TCF, T-cell transcription factor.…”

High-Resolution Recombination Patterns in a Region of Human Chromosome 21 Measured by Sperm Typing by Irene Tiemann-Boege (34093)

“…Detailed study of one of the new hot spots revealed a sperm donor with a decrease in recombination intensity at the canonical recombination site but an increase in crossover activity nearby. …”

Cyclin-dependent kinase inhibitor flavopiridol promotes remyelination in a cuprizone induced demyelination model by Guiyun Mi (835541)

“…In the first experiment of this study, we examined the expression of cell cycle related genes in brains of mice following CPZ administration for 5 weeks by means of microarray assay. In addition, we performed a double labeling of BrdU and Ki-67 to calculate cell cycle exit index in the mice. …”

Data_Sheet_6_v1_The mTOR inhibitor rapamycin suppresses trigeminal neuropathic pain and p-MKK4/p-p38 mitogen-activated protein kinase-mediated microglial activation in the trigemin... by Ji-Hee Yeo (15288553)

Table_2_Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SA... by Krishna P. Maremanda (9356819)

“…Aging plays an important role in various infectious diseases including the SARS-CoV-2 infection. Lung immunoblot analysis of smokers, COPD and IPF subjects revealed increased abundance of proteases and receptor/spike protein like TMPRSS2, furin, and DPP4 in association with a slight increase in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor ACE2 levels.…”

Data_Sheet_4_v1_The mTOR inhibitor rapamycin suppresses trigeminal neuropathic pain and p-MKK4/p-p38 mitogen-activated protein kinase-mediated microglial activation in the trigemin... by Ji-Hee Yeo (15288553)