Obesity and leptin resistance in <i>Bbs4^−/−</i> mice are rescued by <i>LAP-BBS4</i>. by Xitiz Chamling (390467)

“…Data are presented as mean +/− SEM, n = 10 per genotype. <b>B)</b> Weight change and food intake was measured in the WT (blue), <i>BBS4^tg</i> (green), and <i>Bbs4^−/−</i>(red) mice upon vehicle (PBS) or leptin injection<b>. i)</b> When compared to vehicle injection, food intake of WT mice was significantly reduced on day 1 and 2 after beginning leptin injection (*P<0.05), and the food intake of <i>BBS4^tg</i> mice was decreased on day 2 after beginning leptin injection (Ψ P<0.05). …”

Supplementary Material for: Evolution of growth following anti-TNF-α therapy in paediatric Crohn’s disease: data from the Swiss IBD Cohort Study by figshare admin karger (2628495)

“…Growth of patients treated with anti-TNF biologics and immunomodulators was analyzed by linear regression over 5 years and compared within each subgroup by paired Student t-tests 1 year (T1), 2 years (T2) and 5 years (T5) after treatment initiation. …”

Evaluation of retinal and choroidal microvascular changes in patients who received hydroxychloroquine by optical coherence tomography angiography by Esat Cinar (10366844)

“…The macular flow area (superficial, deep, and choriocapillaris), superficial and deep vessel density, foveal avascular zone area, central foveal thickness, and subfoveal choroidal thickness parameters were measured by optical coherence tomography angiography. Results: The mean age of the 28 patients who received hydroxychloroquine and the 28 age-matched controls was 45.5 ± 11.1 years (range: 29-70 years) and 44.5 ± 13.9 years (range: 28-70 years), respectively. …”

Recovery cycle analysis and regression models demonstrating the refractoriness and relatively refractory period (RRP) against age. by Hsing-Jung Lai (821293)

“…<p><b>A</b>, Compared to NC1 and NC2 (the meaning of symbols are the same as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0141935#pone.0141935.g001" target="_blank">Fig 1</a>), the refractoriness (at 2.5 ms, 91.8±28.0% for patient vs. 27.1±4.5% for NC2, <i>p</i> = 0.007) and relatively refractory period (RRP) (3.59±0.18% for patient vs. 3.04±0.07% for NC2, <i>p</i> = 0.0083) are significantly elevated in motor axons of patients, but not in carriers. …”

<i>ITP</i> regulates thirst and water intake. by Martina Gáliková (3274566)

“…Sample size: <i>daGS>ITP</i> off: n = 47 (1 h), n = 45 (1.5 h), n = 45 (3 h); <i>daGS>ITP</i> on: n = 46 (1 h), n = 44 (1.5 h), n = 43 (3 h). …”

Fisher information vs. frequency. by Sina Tootoonian (12024799)

“…Positive coefficients indicate information increases with frequency, negative coefficients that it decreases. Centres of orange markers indicate the integral length scale (<i>L</i>_<i>U</i>, see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0297754#sec016" target="_blank">Methods</a> Sec 5.2.8) in the vertical direction (orthogonal to the mean flow) of the vertical velocity field, computed at the midline where the odour sources were located (‘origin’, <i>L</i>_<i>U</i> = 0.85<i>ϕ</i>) and at the probe location (‘probe’, <i>L</i>_<i>U</i> = 2.6<i>ϕ</i>). …”

Color space representation across objects within a CNN layer. by JohnMark Taylor (8329326)

“…Even in these minimally simple form stimuli, mean pairwise color space similarity decreases over the course of processing. e. …”

Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1α and VEGF recept... by Nadine Mahfouz (4097566)

“…</p><p>Methods</p><p>AGS (gastric cancer), Caco-2 (colorectal cancer) and HepG2/C3A (hepatocellular carcinoma), were treated with telomerase inhibitors BIBR-1232 (10μM) and costunolide (10μM), with bevacizumab (Avastin® at 5 ng/ml or 100μg/ml) or with a combination of both types of inhibitors. …”

Gut microbiota features associated with <i>Clostridioides difficile</i> colonization in puppies by Alexander S. F. Berry (6714761)

Figure 5 from Multiplexed Imaging Mass Cytometry Reveals Tumor-immune Microenvironment–dependent Hormone Receptor Expression in Adult-Type Ovarian Granulosa Cell Tumors by Eleonora Y. Khlebus (20814571)

“…The <i>x</i>-axis indicates the FC (log₂ scaled), and the <i>y</i>-axis shows the adjusted <i>P</i> value (log₁₀ scaled). Each point represents a different gene; the red/blue color of the points categorize genes with increased/decreased expression in the AGCT-2 subtype, highlighting collagen-related genes as top genes with increased expression in AGCT-2. …”

Image_2_Schistosoma mansoni Infection Is Impacted by Malnutrition.TIF by Poliane Silva Maciel (10327754)

“…Mice fed with this diet showed: (i) significant reduction in body weight and serum albumin levels before infection, (ii) decreased levels of all biochemical parameters evaluated before perfusion, (iii) decreased numbers of schistosome eggs trapped in intestines and impaired parasite fecundity, (iv) a delay in the granuloma development with a smaller granuloma area, and (v) reduced levels of IL-4 and IFN-γ in the liver. …”

Involvement of MT2 receptors in protective effects of melatonin against cisplatin-induced gastrointestinal damage in mice by Anita Eugenia Alencar Santos Ribeiro (14211262)

“…Compared with the control, CP decreased GE. Pretreatment with NAC and MLT (5 and 10 mg/kg) did not prevent CP-induced gastric dysmotility; however, pretreatment with 20 mg/kg MLT prevented this effect. …”

Image_1_Schistosoma mansoni Infection Is Impacted by Malnutrition.TIF by Poliane Silva Maciel (10327754)

“…Mice fed with this diet showed: (i) significant reduction in body weight and serum albumin levels before infection, (ii) decreased levels of all biochemical parameters evaluated before perfusion, (iii) decreased numbers of schistosome eggs trapped in intestines and impaired parasite fecundity, (iv) a delay in the granuloma development with a smaller granuloma area, and (v) reduced levels of IL-4 and IFN-γ in the liver. …”

Withaferin-A Reduces Type I Collagen Expression In Vitro and Inhibits Development of Myocardial Fibrosis In Vivo by Azariyas A. Challa (143195)

“…Vimentin is a primary target of Withaferin-A (WF-A). Therefore, we hypothesized that WF-A may reduce type I collagen production by disrupting vimentin filaments and decreasing the stability of collagen mRNAs. …”

Supplementary Material for: Risk Factors and Outcomes of Emergency Room Visits in Intestinal Behçet’s Disease by Park J. (3112986)

“…<b><i>Results:</i></b> One hundred eighty-five patients (30.5%) visited the ER at least once (total visits, 510). …”

Data_Sheet_1_A Novel Gene vp0610 Negatively Regulates Biofilm Formation in Vibrio parahaemolyticus.docx by Fufeng Jiang (10575632)

“…Several important proteins are involved in biofilm formation; however, the identity and function of many remain unknown. In this study, we discovered a hypothetical protein, VP0610 that negatively regulates biofilm formation in Vibrio parahaemolyticus, and we found that the loss of vp0610 typically results in pleiotropic phenotypes that contribute toward promoting biofilm formation, including significantly increased insoluble exopolysaccharide production and swimming motility, decreased soluble exopolysaccharide production, and decreased bis-(3′-5′)-cyclic dimeric guanosine monophosphate production. …”

Image 1_Uptake of iron from ferrous fumarate can be mediated by clathrin-dependent endocytosis in Hutu-80 cells.tiff by Agata Tarczykowska (20620430)

“…Iron uptake (ferritin L) from ferrous fumarate (0.5 mM, 24 h) in DMT1 silenced cells was significantly decreased (60% ± 11%) in comparison to iron controls while a 1-h dose of ferrous fumarate (0.5 mM) significantly decreased ferritin L formation in the presence of the clathrin inhibitor chlorpromazine (61% ± 10%, in post-confluent cells and 37% ± 9% in non-confluent cells). …”

Cross Sectional Survey of Influenza Antibodies before and during the 2009 Pandemic in Shenzhen, China by Chun-Li Wu (277604)

“…We found that the 0–5 age group had an increased antibody level for all types of seasonal influenza during the pandemic compared to the pre-outbreak level, in contrast with almost all other age groups, in which the antibody level decreased. …”

DataSheet_1_Retinoic Acid Alleviates Cisplatin-Induced Acute Kidney Injury Through Activation of Autophagy.docx by Junxia Wu (8601516)

“…Then we established Atg5^flox/flox:Cagg-Cre mice in which Cagg-Cre is tamoxifen inducible, and Atg5 is conditional deleted after tamoxifen injection. …”

How Ionic Strength Affects the Conformational Behavior of Human and Rat Beta Amyloids – A Computational Study by Zdeněk Kříž (5654860)

“…It is possibly due to different amino acid sequences at positions 5, 10 and 13. To address this issue, we performed series of 100 ns long trajectories (each trajectory was run twice with different initial velocity distribution) on amyloid beta (1–42) with the human and rat amino acid sequence in three different environments: water with only counter ions, water with NaCl at a concentration of 0.15 M as a model of intracellular Na⁺ concentration at steady state, and water with NaCl at a concentration of 0.30 M as a model of intracellular Na⁺ concentration under stimulated conditions. …”