AA quantitatively affects mESC neuronal differentiation and maintains pluripotency. by Sandro L. Pereira (491558)

“…TuJ1 expression consistently decreased in cells treated with AA starting on day 2, 5 and 8 on both cell lines (A). …”

Supplementary Material for: Healthcare Costs and Utilization among Patients Hospitalized for Malignant Pleural Effusion by Shafiq M. (8553936)

“…<b><i>Results:</i></b> We analyzed 92,034 hospital discharges spanning a decade (2004–2014). Yearly hospitalizations steadily decreased from 38,865 to 23,965 during this time frame, the mean LOS decreased from 7.7 to 6.3 days, and the adjusted hospital mortality decreased from 7.9 to 4.5% (<i>p</i> = 0.00 for all trend analyses). …”

Mendelian randomization highlights the causal role of normal thyroid function on blood lipid profiles by Yanjun Wang (9719672)

Table_1_Diel Patterns of Variable Fluorescence and Carbon Fixation of Picocyanobacteria Prochlorococcus-Dominated Phytoplankton in the South China Sea Basin.docx by Yuyuan Xie (2614804)

“…We found that phytoplankton photosynthetic performance at stations SEATS and SS1 were characterized by a nocturnal decrease, dawn maximum, and midday decrease of the maximum quantum yield of PSII (Fv(′)/Fm(′), which has been denoted as both F_v/F_m and Fv′/Fm′) in the nutrient-depleted surface layer. …”

Structure Based Identification and Characterization of Flavonoids That Disrupt Human Papillomavirus-16 E6 Function by Jonathan J. Cherry (501180)

The interplay between tauopathy and aging through interruption of UPR/Nrf2/autophagy crosstalk in the Alzheimer’s disease transgenic experimental models by Javad Amini (15446400)

Anti-inflammatory effects and beneficial effects of the feed additive <i>Urtica cannabina</i> L. in zebrafish by Wu Dong (1376829)

Ischemia depresses the amplitude of evoked synaptic transmission without changes in the presynaptic volley amplitude. by Shirin Jalini (2551054)

“…<p>(A). fEPSPs were recorded from the stratum radiatum in the CA1 region while the Schaffer collaterals were stimulated every 15 s. fEPEP amplitude decreased reversibly in a time-dependent manner after 2 min (n = 7), 4 min (n = 5), and 6 min (n = 5) of OGD. …”

Involvement of clathrin-mediated endocytosis in NTBI uptake by PBMCs and HepG2 cells. by Joao Arezes (488491)

“…<p>(A–B) ⁵⁵Fe uptake by PBMCs and HepG2 cells in the presence of 0.45M of sucrose (A) or 80 µM of Dynasore (B) to inhibit clathrin-mediated endocytosis, after incubation with 5 µM of ⁵⁵Fe-citrate (5∶100) at 37°C (C–D) ¹²⁵I-Transferrin internalization in the presence of 0.45M of sucrose (C) or 80 µM of Dynasore (D). …”

MSR algorithm analysis. by Federico Comoglio (224744)

“…(B) The mean move length significantly decreases as a function of the protein length. …”

Molecular pathways underlying degeneration in synapse-enriched fractions are conserved across diverse neurodegenerative conditions. by Thomas M. Wishart (138237)

“…Representative bands from quantitative fluorescent western blot experiments on synapse-enriched fractions from wild-type (WT) and R6/2 mice. C. Bar chart (mean±SEM) showing quantitative fluorescent western blot data for protein expression levels in synapse-enriched fractions from the cerebellum generated from a mouse model of spinocerebellar ataxia type 5 (βIII-spectrin KO mice) compared to wild-type controls (N≥3 mice per genotype). …”

Vulnerability to high fat diet-induced obesity. by Alessandro Bartolomucci (165364)

“…At baseline, when mice were fed standard diet, all experimental groups showed a decrease in body weight, while controls (Con) showed a slight increase (F(3,23) = 3.2, p<0.05). …”

Selective Enrichment of Cysteine-Containing Phosphopeptides for Subphosphoproteome Analysis by Mingming Dong (1471396)

“…Interestingly, amino acid residues surrounding the identified phosphosites were enriched with buried residues (L, V, A, C) while depleted with exposed residues (D, E, R, K). …”

DataSheet_2_Molecular characterization of cross-kingdom RNA interference in Botrytis cinerea by tomato small RNAs.xlsx by Si Qin (3627863)

“…In order to study the functionality of this plant sRNA in reducing the Bcspl1 transcript level, we generated a fungal mutant that contained a 5-nucleotide substitution that would abolish the interaction between the transcript and the sRNA without changing the encoded protein sequence. …”

Modelling of the effects of En1 and En2 on hippocampal cells. by Asma Soltani (4356841)

“…In normal conditions (black lines), low levels of endogenous secreted En1 (from GABA cell for instance) could participate to dendritogenesis (1), spinogenesis (2) (insert), and mTOR signaling (3) in neighbor glutamatergic neurons. In a pathological context, such as autism (red lines), a rise of En2 expression and secretion would generate additional effects, i.e. the increase in dendritic complexity of GABA cells (4), a decrease of clustered PSD95 (5), and the mispairing of glutamatergic synapses (6) (insert). …”

cGMP-Dependent Protein Kinase Type I Is Implicated in the Regulation of the Timing and Quality of Sleep and Wakefulness by Sonja Langmesser (57421)

“…Moreover, PRKG1 deficiency results in an aberrant pattern, and consequently a reduced quality, of sleep and wakefulness, possibly due to a decreased wake-promoting output of the circadian system impinging upon sleep.…”

Altered Cerebrospinal Fluid Proteins in Smith–Lemli–Opitz Syndrome by Wenping Li (440398)

Olfactory Bulb Glomerular NMDA Receptors Mediate Olfactory Nerve Potentiation and Odor Preference Learning in the Neonate Rat by Rebecca Lethbridge (173780)

“…<em>Ex vivo</em> experiments using bulbs from trained rat pups reveal an increase in the AMPA/NMDA EPSC ratio post-training, consistent with an increase in AMPA receptor insertion and/or the decrease in NMDAR subunits. These results support a model of a cAMP/NMDA interaction in generating rat pup odor preference learning.…”

Use of 2-Aminopurine Fluorescence To Examine Conformational Changes during Nucleotide Incorporation by DNA Polymerase I (Klenow Fragment)^† by Vandana Purohit (2947848)

“…Finally, when the primer had a 3‘-OH, a fluorescence decrease with a rate equal to the rate of nucleotide incorporation was observed with both 0 and +1 position reporters. …”

An immunohistochemically stained photomicrograph of the stomach mucosa using an anti-TLR4 antibody. by Rehab F. Taher (20478600)

“…<p>(a) few TLR4-positively stained cells in the normal group; (b) the control ethanol group showed elevated TLR4 expression and a higher proportion of positive cells having deep brown coloring, (c) Omeprazole group showed reduction in the percentage of TLR4 positive cells with strong brown coloring, (d) PM-EtOH (25 mg/kg) group showed lowered percentage of TLR4 positive cells with weak cytoplasmic staining, (e) PM-EtOH (5o mg/kg) group showed decreased percentage of TLR4 positive cells, (f) PM-EtOH (100 mg/kg) group giving weak TLR4 expression, with a significant decrease in TLR4-positively stained cells(TLR4 immunohistochemical staining; Scale bar=100µm).…”