Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

An outline of our methodology. by Krishna Bathina (12883820)

TachypleginA treatment causes a decrease in the motor activity of the TgMyoA motor complex. by Aoife T. Heaslip (207534)

Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease by Christine M. LaPash Daniels (796881)

“…Here we tested whether lithium treatment would decrease levels of GFAP in a mouse model of Alexander disease. …”

Effects of A1AR expression on response to hypoxia at E9.5 and E12.5. by Daniela L. Buscariollo (140729)

“…In hypoxia, E9.5 A1AR +/− heart rates decreased then returned to baseline levels following recovery in room air (p<0.0001 and p<0.01, for t = 25 and t = 40 compared to t = 0, respectively). …”

<i>SIRT6</i> Minor Allele Genotype Is Associated with >5-Year Decrease in Lifespan in an Aged Cohort by Mindi J. TenNapel (679433)

eIF5a is up-regulated in unruptured AAAs and decreased in ruptured AAAs. by Dong Ma (584680)

Subjects:

Arginine supplementation decreases the inhibitory effect exerted by 5-flucytosine in <i>C</i>. <i>glabrata</i>. by Catarina Costa (322963)

DataSheet_1_Circulating exosomes decrease in size and increase in number between birth and age 7: relations to fetal growth and liver fat.pdf by Marta Díaz (337207)

“…Circulating exosomes of SGAs (as compared to those of AGAs) had a larger size at birth [146.8 vs 137.8 nm, respectively; p=0.02], and were in lower number at ages 2 [4.3x10¹¹vs 5.6x10¹¹ particles/mL, respectively; p=0.01] and 7 [6.3x10¹¹vs 6.8x10¹¹ particles/mL, respectively; p=0.006]. …”

V5-SgG2 transfection in the epidermis modifies the termination site of peptidergic FNE. by Jorge Rubén Cabrera (685511)

Survival data for E. coli K-12 represented as change in log₁₀ concentration (CFU/mL) from pre-UV disinfection (N0), immediately after UV disinfection (Nt), and after 24... by Daniel Ma (12698752)

Dynamin inhibitors decrease the viability of acute leukemia cells. by Christopher von Beek (11401835)

Scatter measures the quality of retinotopy and values decrease in development. by Spencer L. Smith (366143)

Image_5_Decreased Type I Interferon Production by Plasmacytoid Dendritic Cells Contributes to Severe Dengue.jpeg by Vinit Upasani (4169677)

The point mutants E559A, E563A and K567A display altered DNA-binding kinetics. by Bettina Hüntelmann (566945)

“…(G, H) Reduced nuclear export kinetics of STAT1-E559A and -E563A. HeLa cells expressing GFP-tagged wild-type or mutant STAT1 (scale bar 10 µm) were prestimulated for 45 min with IFNγ to induce nuclear accumulation (top panel) and then treated for 6 min in the presence of 50 µg/ml digitonin in ice-cold transport buffer (bottom panel). …”

<b>Adipose TGR5 deletion promotes hepatic steatosis through decreasing adiponectin secretion in mice</b> by Jiahui Li (646449)

Stx2 and SubAB decrease HGEC viability. by María M. Amaral (439445)

The decrease or inhibition of Hsp90 induced REST degradation. by Raúl Orozco-Díaz (7067624)

“…<p>(A) Effect of Hsp90α ASO on cell viability. Differentiated SH-SY5Y cells were transfected with different concentrations of Hsp90α ASO. …”

Nesfatin-1 decreased excitability of GI-neurons in DVC. by Jing Dong (102657)