Pep4 overexpression decreased APCs in Vps21- and ESCRT-mutant cells after nitrogen starvation. by Zulin Wu (4451572)

“…Either Pep4 or Snf7 in <i>snf7Δ</i> cells facilitated GFP-Atg8 degradation and prApe1 maturation (bottom), but only Snf7 (not Pep4) promoted phagophore closure in <i>snf7Δ</i> cells. The red arrows point to these key results. <b>F.</b> Quantification of the immunoblot results shown in panel E was performed as described in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1010431#pgen.1010431.s008" target="_blank">S8F Fig</a>. …”

GRIP1^-/- platelets do not have decreased velocity in ionophore-stimulated blood vessels. by Kristina L. Modjeski (3123072)

“…D) Representative images of WT and GRIP1^-/- platelets before and after ionophore treatment in mesenteric arterioles (smaller, rounder platelets are rolling (arrow), magnification 20X). E) GRIP1^-/- platelets have a trend toward reduced vWF adhesion in vitro. …”

Gramine Derivatives Targeting Ca²⁺ Channels and Ser/Thr Phosphatases: A New Dual Strategy for the Treatment of Neurodegenerative Diseases by Rocío Lajarín-Cuesta (1530580)

“…Hence, we propose this multitarget approach as a new and promising strategy for the treatment of neurodegenerative diseases.…”

Surveillance of HIV Transmitted Drug Resistance in Latin America and the Caribbean: A Systematic Review and Meta-Analysis by Santiago Avila-Rios (3160959)

Subjects:

Decreased MMP-9 protein expression induced by STIP1 knockdown is independent of common signaling pathways. by Hsin-Shih Wang (8802)

“…(B) Decreased MMP-9 protein expression induced by siRNA knockdown of STIP1 was unaffected by exposure either to the DNA methylation inhibitor 5-aza-2’-deoxycytidine (AZA; 10 μM) or the histone deacetylase inhibitor trichostatin A (TSA; 20 nM). …”

Down-regulation of GPER reverses the decreased expression of PCNA and cell morphology changes caused by G-1. by Fen Li (337013)

datasheet1_Allopregnanolone Decreases Evoked Dopamine Release Differently in Rats by Sex and Estrous Stage.docx by Ana Paula S. Dornellas (9983996)

“…As allopregnanolone is a potent positive allosteric modulator of GABA_A receptors, and GABA_A receptors can regulate dopamine release, we hypothesized that allopregnanolone would reduce phasic fluctuations in mesolimbic dopamine release that are important in learning and reward processing. …”

A647D mutation decreases I_Na of WT and P1332L when co-expressed. by Jie Liu (15128)

DataSheet_1_microRNA-144/451 decreases dendritic cell bioactivity via targeting interferon-regulatory factor 5 to limit DSS-induced colitis.pdf by Zhijie Lin (173992)

“…Thus, our results reveal a novel miR144/451-IRF5 pathway in DCs that protects experimental colitis. …”

Response of small airway tissues infected with EV-D94 and decreasing doses of EV-D68. by Ines Cordeiro Filipe (5849144)

“…<p>Tissues were infected with 1E7 RNA copies of EV-D94 (equivalent to 2,46E4 TCID50) and 1E7 RNA copies of EV-D68 (3,3E5 TCID50) as well as decreasing doses of the latter. …”

Data Sheet 1_Probiotic Limosilactobacillus reuteri KUB-AC5 decreases urothelial cell invasion and enhances macrophage killing of uropathogenic Escherichia coli in vitro study.pdf by Arishabhas Tantibhadrasapa (13929639)

“…The human bladder epithelial cell line UM-UC-3 was used to assess the adhesion and pathogen-attachment inhibition properties of AC5 on UPEC.</p>Results and discussion<p>Our data showed that AC5 can attach to UM-UC-3 and decrease UPEC attachment in a dose-dependent manner. …”

RSSI of connected WiFi AP in MPTCP and heterogeneous handover using eHMP. by Khong-Lim Yap (8357256)

The average retransmission rate using the proposed eHMP, MPTCP and MPTCP with mobility prediction. by Khong-Lim Yap (8357256)

Longitudinal analysis of exploratory behavior during housing in Marlau™ cages is in favor of decreased anxiety in “enriched” rats. by Raafat P. Fares (288906)

Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists by Dilip K. Tosh (1668115)

“…While screening off-target effects of rigid (<i>N</i>)-methanocarba-adenosine 5′-methylamides as A₃ adenosine receptor (AR) agonists, we discovered μM binding hits at the δ-opioid receptor (DOR) and translocator protein (TSPO). …”

Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists by Dilip K. Tosh (1668115)

“…While screening off-target effects of rigid (<i>N</i>)-methanocarba-adenosine 5′-methylamides as A₃ adenosine receptor (AR) agonists, we discovered μM binding hits at the δ-opioid receptor (DOR) and translocator protein (TSPO). …”

Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists by Dilip K. Tosh (1668115)

“…While screening off-target effects of rigid (<i>N</i>)-methanocarba-adenosine 5′-methylamides as A₃ adenosine receptor (AR) agonists, we discovered μM binding hits at the δ-opioid receptor (DOR) and translocator protein (TSPO). …”

Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists by Dilip K. Tosh (1668115)

“…While screening off-target effects of rigid (<i>N</i>)-methanocarba-adenosine 5′-methylamides as A₃ adenosine receptor (AR) agonists, we discovered μM binding hits at the δ-opioid receptor (DOR) and translocator protein (TSPO). …”

Table_5_NOTCH1 mutation associates with impaired immune response and decreased relapse-free survival in patients with resected T1-2N0 laryngeal cancer.docx by Xiao-yang Gong (13103400)

“…A total of 469 genomic alterations were detected in 211 distinct cancer-relevant genes, and the genes found to be mutated in more than five patients (>10%) included tumor protein p53 (TP53, 78.5%), FAT atypical cadherin 1 (FAT1, 26%), LDL receptor related protein 1B (LRP1B, 19%), cyclin dependent kinase inhibitor 2A (CDKN2A, 17%), tet methylcytosine dioxygenase 2 (TET2, 17%), notch receptor 1 (NOTCH1, 12%) and neuregulin 1 (NRG1, 12%). …”

Hyperlipidemia-Associated Renal Damage Decreases Klotho Expression in Kidneys from ApoE Knockout Mice by Cristina Sastre (503532)

“…Hyperlipidemia accelerates the progression of renal damage, but the mechanisms of the deleterious effects of hyperlipidemia remain unclear.</p><p>Methods</p><p>We evaluated whether hyperlipidemia modulates Klotho expression in kidneys from C57BL/6 and hyperlipidemic apolipoprotein E knockout (ApoE KO) mice fed with a normal chow diet (ND) or a Western-type high cholesterol-fat diet (HC) for 5 to 10 weeks, respectively.…”