Causal relationships between interleukins, interferons and COVID-19 risk: a Mendelian randomization study by Chao Wang (146527)

“…Finally, sensitivity analyses were applied to assess the robustness of results. As a result, one IFN (IFN-W1) and five ILs (IL-5, IL-6, IL-13, IL-16 and IL-37) were identified to significantly decrease the COVID-19 risk. …”

DataSheet_1_Reduced prevalence of drug-related problems in psychiatric inpatients after implementation of a pharmacist-supported computerized physician order entry system - a retro... by Katharina Wien (18330384)

“…To date, no study has been reported on the types and prevalence of drug-related problems (DRPs) before and after CPOE implementation in a psychiatric inpatient setting. The aim of this retrospective before-and-after cohort study was to investigate whether the implementation of a CPOE system with CDSS accompanied by the introduction of regular medication plausibility checks by a pharmacist led to a decrease of DRPs during hospitalization and unsolved DRPs at discharge in psychiatric inpatients.…”

B28Bn(6–14)-induced loss of mitochondrial transmembrane potential. A by Hao Yang (328526)

The representative trace of the LDF signal after the intravital injection of ADP to a mouse (a), parameters of the curve calculated by PAMA software, the LDU values are multiplied... by Tomasz Przygodzki (4277908)

“…<p>The following parameters characterizing the curve were calculated using PAMA software, as described in ‘<i>Materials and Methods</i>’ and are expressed in arbitrary Laser Doppler Flow units (LDU): <b>A</b>_<b>max</b><b>—</b>the maximum decrease in blood flow with respect to the baseline; <b>DA–</b>the maximal restoration of flow with respect to the baseline; <b>T</b>_<b>d</b><b>—</b>time from the injection of ADP to 10% of the maximum decrease in blood flow (A_max); <b>T</b>_<b>r</b><b>−</b>time from 10% to 90% of the maximum decrease in blood flow (A_max); <b>T</b>_<b>c</b><b>−</b>time from 90% of A_max to 90% of DA; <b>T</b>_<b>f</b><b>−</b>time from 90% of DA to 10% of DA; <b>V</b>_<b>0r</b><b>–</b>the maximal rate of the decrease in blood flow; <b>V</b>_<b>Avgr</b><b>−</b>the rate of decrease averaged through T_r; <b>V</b>_<b>0f</b><b>–</b>the maximal rate of the restoration of blood flow; <b>V</b>_<b>Avgf</b><b>−</b>the rate of restoration averaged through T_f; <b>AUC–</b>the area under the curve from 10% of A_max to 10% DA; <b>AUC</b>_<b>r</b><b>−</b>the area under the curve from 10% to 90% of A_max; <b>AUC</b>_<b>c</b><b>−</b>the area under the curve from 90% of A_max to 90% of DA; <b>AUC</b>_<b>f</b><b>−</b>the area over the curve from 90% to 10% of DA.…”

Deformative Transition of the Menschutkin Reaction and Helical Atropisomers in a Congested Polyheterocyclic System by Yung-Yu Chang (1724704)

“…Conformational flexibility in dipyridylethene <b>9</b> is clearly shown by its complexation with BH₃ to form helical atropisomers (<i>P,P</i>/<i>M,M</i>)-<b>10</b>. The p<i>K</i>_a values of the conjugate acids of <b>1A</b> and <b>9</b> in acetonitrile were determined to be 4.65 and 5.07, respectively, which are much smaller compared to that of pyridine <b>14a</b> (p<i>K</i>_a = 12.33), implying that the basicity, nucleophilicity, and amine alkylation rates of <b>1A</b> and <b>9</b> are markedly decreased by the severe steric hindrance of the flanking phenyl rings in the polyheterocycles.…”

Deformative Transition of the Menschutkin Reaction and Helical Atropisomers in a Congested Polyheterocyclic System by Yung-Yu Chang (1724704)

“…Conformational flexibility in dipyridylethene <b>9</b> is clearly shown by its complexation with BH₃ to form helical atropisomers (<i>P,P</i>/<i>M,M</i>)-<b>10</b>. The p<i>K</i>_a values of the conjugate acids of <b>1A</b> and <b>9</b> in acetonitrile were determined to be 4.65 and 5.07, respectively, which are much smaller compared to that of pyridine <b>14a</b> (p<i>K</i>_a = 12.33), implying that the basicity, nucleophilicity, and amine alkylation rates of <b>1A</b> and <b>9</b> are markedly decreased by the severe steric hindrance of the flanking phenyl rings in the polyheterocycles.…”

Deformative Transition of the Menschutkin Reaction and Helical Atropisomers in a Congested Polyheterocyclic System by Yung-Yu Chang (1724704)

“…Conformational flexibility in dipyridylethene <b>9</b> is clearly shown by its complexation with BH₃ to form helical atropisomers (<i>P,P</i>/<i>M,M</i>)-<b>10</b>. The p<i>K</i>_a values of the conjugate acids of <b>1A</b> and <b>9</b> in acetonitrile were determined to be 4.65 and 5.07, respectively, which are much smaller compared to that of pyridine <b>14a</b> (p<i>K</i>_a = 12.33), implying that the basicity, nucleophilicity, and amine alkylation rates of <b>1A</b> and <b>9</b> are markedly decreased by the severe steric hindrance of the flanking phenyl rings in the polyheterocycles.…”

Protein-protein docking for Parkin and a charged E2∼Ub complex. by Thomas R. Caulfield (655752)

“…The docking in the same position is shown and rotated 180° to reveal the other side. Residues of the Ubch5a-Ub complex are indicated by color (dark green and brown, respectively). …”

Cerebral Venous Sinus Thrombosis - Diagnostic Strategies and Prognostic Models: A Review by Penka A. Atanassova (7944506)

“…Patients with CVST commonly present with headache, although some develop a focal neurological deficit, decreased level of consciousness, seizures, or intracranial hypertension without focal neurological signs. …”

Deformative Transition of the Menschutkin Reaction and Helical Atropisomers in a Congested Polyheterocyclic System by Yung-Yu Chang (1724704)

“…Conformational flexibility in dipyridylethene <b>9</b> is clearly shown by its complexation with BH₃ to form helical atropisomers (<i>P,P</i>/<i>M,M</i>)-<b>10</b>. The p<i>K</i>_a values of the conjugate acids of <b>1A</b> and <b>9</b> in acetonitrile were determined to be 4.65 and 5.07, respectively, which are much smaller compared to that of pyridine <b>14a</b> (p<i>K</i>_a = 12.33), implying that the basicity, nucleophilicity, and amine alkylation rates of <b>1A</b> and <b>9</b> are markedly decreased by the severe steric hindrance of the flanking phenyl rings in the polyheterocycles.…”

The Effect of Chronic Stress on Apoptosis Regulation and Oncogenesis Evolution: A Theoretical Approach. by DIMITRIOS KIMOGLOU (20499350)

Influence of natural gas composition on adsorption in calcite Nanopores: A DFT study by Elbashier E.

“…The nanopores absorbed up to 28 and 24 molecules of CH4 and CO2, respectively, and the adsorption energy decreased to −0.0062 and −0.0075 eV/Å2 for each. Although the nanopore was filled spatially by the molecules, its surface still has an affinity to absorb more gas molecules energetically. …”
Get full text
Get full text
Get full text

Pyrvinium inhibits WNT signaling in a CK1α dependent manner. by Bin Li (39349)

“…<p><b>A</b>. The expression of the WNT target gene: <i>AXIN2</i> was determined from NIH 3T3 cells expressing control or <i>CK1α</i>-specific shRNAs. …”

Supplementary Material for: Differential Impact of Cognitive Impairment in MCI Patients: A Case-Based Report by Pergher V. (9038528)

Expression pattern of a <i>puc</i> reporter line in the central brain. by David Kapfhamer (295513)

“…<p><b><i>A</i></b>, Rescue of decreased <i>puc¹/+</i> ethanol-induced locomotor stimulation in the <i>NP1311</i> expression pattern. …”

Supplementary Material for: Trends in Literature on Cerebral Bypass Surgery: A Systematic Review by Grüter B.E. (11166240)

“…<b><i>Methods:</i></b> A systematic literature research was conducted using PubMed, Web of Science, EMBASE, and SCOPUS databases. …”

Control of Severe, Life-Threatening External Bleeding in the Out-of-Hospital Setting: A Systematic Review by Nathan P. Charlton (6056651)

Table_1_The Metabolic Changes and Immune Profiles in Patients With COVID-19.pdf by Bing He (135034)

“…<p>To explore the metabolic changes and immune profiles in patients with COVID-19, we analyzed the data of patients with mild and severe COVID-19 as well as young children with COVID-19. …”

Ligand-dependent stability of a 240 kDa protein can be probed by FASTpp. by David P. Minde (304427)

“…A gradual decrease in the band intensity at higher temperatures indicates unfolding. …”

Acute Variations in Retinal Vascular Oxygen Content in a Rabbit Model of Retinal Venous Occlusion by Gilberto Raul Lopez Jaime (120485)

“…</p> <h3>Results</h3><p>One hour after RVO induction, we observed statistically significant reductions in the intravascular oxygen saturation in temporal retinal arteries (85.1±6.1% vs. 80.6±6.6%; p<0.0001) and veins (71.4±5.5% vs. 64.0±4.7%; p<0.0001). …”