Net work vs phase of activation and lattice spacing. Top) We simulated work loops in the half sarcomere model at phases of activation of 0 to 0.95 in 0.05 increments, as well as over lattice spacings from 12 to 18 nm and plotted the new work for each condition. Bottom) We then simulated work loops over the same range, but with the stiffness of either the linear or torsional spring comprising the crossbridge head increased or decreased by 50% separately.... by Travis Carver Tune (21012349)

“…Bottom) We then simulated work loops over the same range, but with the stiffness of either the linear or torsional spring comprising the crossbridge head increased or decreased by 50% separately. …”

SMC-specific knockout of Klf5 (smcKlf5^−/−) exacerbates the progression of Ang II–induced AAA by facilitating ROS formation. by Dong Ma (584680)

The number of Brn3a-expressing cells in retino-collicular co-cultures decreases between DIV4 and DIV12. by Sylvie Voyatzis (332702)

“…(B, C) The density of cells immunoreactive for Brn3a undergoes a reduction of ∼68% between DIV4 and DIV7, and a further decrease of ∼22% between DIV 7 and DIV12. …”

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

Klf5 down-regulation leads to human VSMC senescence. by Dong Ma (584680)

Ubr3 is required for Hh signaling and proper optic vesicle morphogenesis. by Tongchao Li (115391)

Overexpression of ICAM-1 by lymphocytes and decreased of CD62L⁺ cells from late postmenopausal women. by Nicté Figueroa-Vega (741283)

Growth curves (A, strain AWRI R2 (A); B, strain BH8 (B); C, strain Freddo (F)) and accumulated fermentation system mass loss(D, strain A; E, strain B; F, strain F) of <i>S</i>. <i>... by Xiang-yu Sun (748032)

Increased expression of Fz5 receptor matched with a decrease in NeuN immunoreactivity at 16w. by Carlos González-Fernández (2794207)

The effects of GM-CSF on DMN-induced histopathological changes. by Mrigendra Bir Karmacharya (13607415)

Schematic representation of the effects of stepwise bromination of the benzene ring of benzotriazole (Bt), including interdependence of the molecular volume (A) and pK_a (B) of the products with their IC₅₀ for inhibition of protein kinase CK2α: (a) Green arrows follow sequential bromination of the central vicinal C(5)/C(6) atoms, leading to a moderate decrease of pK_a and a large decrease in IC₅₀; (b) Red arrows illustrate the lesser effects of bromination of the peripheral C(4)/C(7) atoms, resulting in a significant decrease of pK_a, with virtually no gain in inhibitory activity; (c) Black lines link products with the same number of bromine atoms, but substantially differing in pK_a and IC₅₀, culminating in the di- and tri-brominated derivatives with inhibitory activities comparable to that of TBBt. by Romualda Wąsik (119538)

Effects of GM-CSF on the DMN-induced inhibition of PPAR-γ expression. by Mrigendra Bir Karmacharya (13607415)

Effects of GM-CSF on DMN-induced TGF-β1 expression. by Mrigendra Bir Karmacharya (13607415)

Western blot analysis of collagen type I, α-SMA, and TGF-β1 in liver. by Mrigendra Bir Karmacharya (13607415)

Effects of GM-CSF on DMN-induced hepatotoxicity. by Mrigendra Bir Karmacharya (13607415)

Effects of GM-CSF on DMN-induced changes in survival and body weights. by Mrigendra Bir Karmacharya (13607415)

Photoaging mice model was made. by Seon-Pil Jin (17364626)

100P homozygous mice show overall decrease in proportions of PV-expressing cells in the P21 neocortex. by Malgorzata Borkowska (3166719)

Patterns of lifetime use of substances by gender. by Daniel Waiganjo Kinyanjui (15877725)

“…The lifetime prevalence of substance use was 41.5%, while that of alcohol use was 36%. For both, a higher mean neuroticism score [substance use- (AOR 1.05, 95%CI; 1, 1.10: p = 0.013); alcohol use- (AOR 1.04, 95%CI; 0.99, 1.09: p = 0.032)] showed increased odds of lifetime use, while a higher mean agreeableness score [substance use- (AOR 0.99, 95%CI; 0.95, 1.02: p = 0.008); alcohol use- (AOR 0.99, 95%CI; 0.95, 1.02: p = 0.032)] showed decreased odds of lifetime use. …”