-
1
-
2
Imlunestrant: First Approval
Argitaratua 2025“...This article summarizes the milestones in the development of imlunestrant leading to this first approval for use in patients with ER+, HER2-, ESR1-mutated advanced or metastatic breast cancer....”
-
3
-
4
Comparing Force Field Treatments in QM/MM Studies of the SARS-CoV‑2 RNA-Dependent RNA Polymerase (RdRp) Mechanism
Argitaratua 2025“...This mechanism was found to be exergonic, with the rate-determining step being the nucleophilic attack, having a free energy barrier of 15.2 kcal mol<sup>–1</sup>. ...”
-
5
A Graph Neural Network for Small-Area Estimation: Integrating Spatial Regularisation, Heterogeneous Spatial Units, and Bayesian Inference
Argitaratua 2025“...(Optional) Execute the first installation cell to install any missing packages....”
-
6
Development of FBXO22 Degraders and the Recruitment Ligand 2‑Pyridinecarboxyaldehyde (2-PCA)
Argitaratua 2025“...Finally, we found that 2-pyridinecarboxaldehyde (2-PCA) functions as a novel electrophilic degron capable of forming a reversible thioacetal with cysteine 326 for recruiting FBXO22. ...”
-
7
Development of FBXO22 Degraders and the Recruitment Ligand 2‑Pyridinecarboxyaldehyde (2-PCA)
Argitaratua 2025“...Finally, we found that 2-pyridinecarboxaldehyde (2-PCA) functions as a novel electrophilic degron capable of forming a reversible thioacetal with cysteine 326 for recruiting FBXO22. ...”
-
8
Application of STUPPIT to identify novel intermediary proteins between SMAD4 and β-catenin, central hubs of BMP and Wnt pathway.
Argitaratua 2025“...Underlying mass spectrometry data can be found in the ProteomeXchange (PXD069286).</p>...”
-
9
-
10
-
11
-
12
Root mean square deviation measurements of monomers.
Argitaratua 2025“...<p><b>A)</b> RMSD of monomer 1 (p1) and <b>B)</b> monomer 2 (p2) calculated using the first frame of each protein as the reference in each case. ...”
-
13
-
14
-
15
Analysis of the binding site of NagS and activity of NagS mutants.
Argitaratua 2025“...<p><b>(a)</b> NagS active site with bound GlcNAc-6P (gray carbons), protein residues are coloured with pale blue and yellow carbons to indicate the 2 monomers forming the active site. 2|Fo|-|Fc| electron density contoured at 1.2 σ is shown as cyan mesh. ...”
-
16
-
17
Image 1_Dynamic duos: learning to care as a pair in the biparental prairie vole (Microtus ochrogaster).jpeg
Argitaratua 2025“...</p>Methods<p>We investigated how prairie voles learn to be parents by observing how their parental care effort changes over two consecutive litters. The first litter represents a naive context while the second litter represents an experienced context....”
-
18
Suggested set of research activities and tools for the RITEC (Children's Digital Play and Well-being) research project
Argitaratua 2025“...</p><p dir="ltr"><br></p><p dir="ltr"><b>Visit 3 ‘Two weeks post-DPE’</b><br>Around two weeks after Visit 2, researchers conducted further interviews and video observations to understand ongoing use of the game. ...”
-
19
-
20