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design optimization » bayesian optimization (Expand Search)
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genes based » gene based (Expand Search), lens based (Expand Search)
design optimization » bayesian optimization (Expand Search)
cell optimization » field optimization (Expand Search), wolf optimization (Expand Search), lead optimization (Expand Search)
binary based » library based (Expand Search), linac based (Expand Search), binary mask (Expand Search)
genes based » gene based (Expand Search), lens based (Expand Search)
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Table 1_A computational framework for optimizing mRNA vaccine delivery via AI-guided nanoparticle design and in silico gene expression profiling.pdf
Published 2025“…Parallelly, we trained a Random Forest regression model on simulated lipid nanoparticles formulations to predict immune activation values and embedded this model into a genetic algorithm to identify optimal lipid nanoparticles design parameters (size, charge, polyethylene glycol content, and targeting). …”
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Presentation 1_A computational framework for optimizing mRNA vaccine delivery via AI-guided nanoparticle design and in silico gene expression profiling.pdf
Published 2025“…Parallelly, we trained a Random Forest regression model on simulated lipid nanoparticles formulations to predict immune activation values and embedded this model into a genetic algorithm to identify optimal lipid nanoparticles design parameters (size, charge, polyethylene glycol content, and targeting). …”
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Table 2_A computational framework for optimizing mRNA vaccine delivery via AI-guided nanoparticle design and in silico gene expression profiling.pdf
Published 2025“…Parallelly, we trained a Random Forest regression model on simulated lipid nanoparticles formulations to predict immune activation values and embedded this model into a genetic algorithm to identify optimal lipid nanoparticles design parameters (size, charge, polyethylene glycol content, and targeting). …”
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Image 1_A computational framework for optimizing mRNA vaccine delivery via AI-guided nanoparticle design and in silico gene expression profiling.png
Published 2025“…Parallelly, we trained a Random Forest regression model on simulated lipid nanoparticles formulations to predict immune activation values and embedded this model into a genetic algorithm to identify optimal lipid nanoparticles design parameters (size, charge, polyethylene glycol content, and targeting). …”
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Image 2_A computational framework for optimizing mRNA vaccine delivery via AI-guided nanoparticle design and in silico gene expression profiling.png
Published 2025“…Parallelly, we trained a Random Forest regression model on simulated lipid nanoparticles formulations to predict immune activation values and embedded this model into a genetic algorithm to identify optimal lipid nanoparticles design parameters (size, charge, polyethylene glycol content, and targeting). …”
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MultiCRISPR-EGA: Optimizing Guide RNA Array Design for Multiplexed CRISPR Using the Elitist Genetic Algorithm
Published 2025“…Computational experiments on Escherichia coli gene targets demonstrate that the EGA can rapidly optimize multiplexed gRNA arrays, outperforming other intelligent optimization algorithms in CRISPR interference (CRISPRi) applications, while the GUI provides real-time design progress control and compatibility with various CRISPR-Cas systems. …”
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<i>OptRAM</i>: <i>In-silico</i> strain design via integrative regulatory-metabolic network modeling
Published 2019“…In this study, we developed a novel strain design algorithm, named OptRAM (<b>Opt</b>imization of <b>R</b>egulatory <b>A</b>nd <b>M</b>etabolic Networks), which can identify combinatorial optimization strategies including overexpression, knockdown or knockout of both metabolic genes and transcription factors. …”
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A* Path-Finding Algorithm to Determine Cell Connections
Published 2025“…Pixel paths were classified using a z-score brightness threshold of 1.21, optimized for noise reduction and accuracy. The A* algorithm then evaluated connectivity by minimizing Euclidean distance and heuristic cost between cells. …”
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Table1_A depth-first search algorithm for oligonucleotide design in gene assembly.DOCX
Published 2022“…Then, the improved depth-first search algorithm is used according to the design principle of pruning optimization to obtain a uniform set of oligonucleotides with very close melting temperatures. …”
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Gex2SGen: Designing Drug-like Molecules from Desired Gene Expression Signatures
Published 2023Subjects: -
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Gex2SGen: Designing Drug-like Molecules from Desired Gene Expression Signatures
Published 2023Subjects: -
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Gex2SGen: Designing Drug-like Molecules from Desired Gene Expression Signatures
Published 2023Subjects: -
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Raw Data for the Thesis: "<i>Enhancing RNAi-Based Pest Control through Effective Target Gene Selection and Optimal dsRNA Design</i>"
Published 2025“…</p><p><br></p><p dir="ltr">Chapter 4 introduces the dsRIP web platform (<a href="https://dsrip.uni-goettingen.de/" target="_blank">https://dsrip.uni-goettingen.de/</a>) for designing sequence-optimized dsRNA for RNAi-based pest control. …”
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