Table 1_A computational framework for optimizing mRNA vaccine delivery via AI-guided nanoparticle design and in silico gene expression profiling.pdf by Valentina Di Salvatore (6296114)

“…<p>Recent concerns about off-target immune activation following non-targeted mRNA vaccine delivery have prompted the need for rational design strategies that optimize nanoparticle formulations. Building upon our previous in silico work using the Universal Immune System Simulator to characterize immune responses to mRNA vaccines, we present a computational framework that integrates synthetic transcriptomics with artificial intelligence-driven optimization to guide the development of safer and more targeted lipid nanoparticles. …”

Presentation 1_A computational framework for optimizing mRNA vaccine delivery via AI-guided nanoparticle design and in silico gene expression profiling.pdf by Valentina Di Salvatore (6296114)

“…<p>Recent concerns about off-target immune activation following non-targeted mRNA vaccine delivery have prompted the need for rational design strategies that optimize nanoparticle formulations. Building upon our previous in silico work using the Universal Immune System Simulator to characterize immune responses to mRNA vaccines, we present a computational framework that integrates synthetic transcriptomics with artificial intelligence-driven optimization to guide the development of safer and more targeted lipid nanoparticles. …”

Table 2_A computational framework for optimizing mRNA vaccine delivery via AI-guided nanoparticle design and in silico gene expression profiling.pdf by Valentina Di Salvatore (6296114)

“…<p>Recent concerns about off-target immune activation following non-targeted mRNA vaccine delivery have prompted the need for rational design strategies that optimize nanoparticle formulations. Building upon our previous in silico work using the Universal Immune System Simulator to characterize immune responses to mRNA vaccines, we present a computational framework that integrates synthetic transcriptomics with artificial intelligence-driven optimization to guide the development of safer and more targeted lipid nanoparticles. …”

Image 1_A computational framework for optimizing mRNA vaccine delivery via AI-guided nanoparticle design and in silico gene expression profiling.png by Valentina Di Salvatore (6296114)

“…<p>Recent concerns about off-target immune activation following non-targeted mRNA vaccine delivery have prompted the need for rational design strategies that optimize nanoparticle formulations. Building upon our previous in silico work using the Universal Immune System Simulator to characterize immune responses to mRNA vaccines, we present a computational framework that integrates synthetic transcriptomics with artificial intelligence-driven optimization to guide the development of safer and more targeted lipid nanoparticles. …”

Image 2_A computational framework for optimizing mRNA vaccine delivery via AI-guided nanoparticle design and in silico gene expression profiling.png by Valentina Di Salvatore (6296114)

“…<p>Recent concerns about off-target immune activation following non-targeted mRNA vaccine delivery have prompted the need for rational design strategies that optimize nanoparticle formulations. Building upon our previous in silico work using the Universal Immune System Simulator to characterize immune responses to mRNA vaccines, we present a computational framework that integrates synthetic transcriptomics with artificial intelligence-driven optimization to guide the development of safer and more targeted lipid nanoparticles. …”

Key gene identification based on two machine learning algorithms. by Lijun Guo (605276)

Distributions of model parameters mirror differentially expressed ion channel genes. by Daniele Linaro (227790)

Reproducing kernel-based semiparametric functional smoothed score estimation with binary responses by Meichen Liu (8168148)

Number of highest variance genes selected per omic for each dataset-approach combination. by Teemu J. Rintala (19333003)

<i>hi</i>PRS algorithm process flow. by Michela C. Massi (14599915)

“…<b>(C)</b> The whole training data is then scanned, searching for these sequences and deriving a re-encoded dataset where interaction terms are binary features (i.e., 1 if sequence <i>i</i> is observed in <i>j</i>-th patient genotype, 0 otherwise). …”

MultiCRISPR-EGA: Optimizing Guide RNA Array Design for Multiplexed CRISPR Using the Elitist Genetic Algorithm by Yangyu Zhang (4609117)

“…Recognizing that more stable gRNAs, characterized by lower minimum free energy (MFE), have prolonged activity and thus higher efficacy, we developed MultiCRISPR-EGA, a graphical user interface (GUI)-based tool that employs the Elitist Genetic Algorithm (EGA) to design optimized single-promoter-driven multiplexed gRNA arrays. …”

Raw Data for the Thesis: "<i>Enhancing RNAi-Based Pest Control through Effective Target Gene Selection and Optimal dsRNA Design</i>" by Doga CEDDEN (12675286)

“…The chapter argues that unbiased, screen-based approaches outperform hypothesis-driven gene selection due to the unpredictable influence of cellular processes on RNAi efficacy. …”

Schematic representation of semi-automated algorithm for organoids analyzing. by Anna Demchenko (18449439)

The pseudocode related to the process of initial harmony generation, with considering SNP locus data. by Fariba Esmaeili (532865)

Stability of cancer clustering results with different pathway sets. by Teemu J. Rintala (19333003)

Stability of cancer clustering results with different feature filters. by Teemu J. Rintala (19333003)

Cluster survival results with different pathway sets. by Teemu J. Rintala (19333003)

Cancer subtype agreement with different pathway sets. by Teemu J. Rintala (19333003)

Supplementary Material for: Penalized Logistic Regression Analysis for Genetic Association Studies of Binary Phenotypes by Yu Y. (3096192)

“…Our estimate of m is the maximizer of a marginal likelihood obtained by integrating the latent log-ORs out of the joint distribution of the parameters and observed data. We consider two approximate approaches to maximizing the marginal likelihood: (i) a Monte Carlo EM algorithm (MCEM) and (ii) a Laplace approximation (LA) to each integral, followed by derivative-free optimization of the approximation. …”

Latent state estimations for experimental data with no stressors. by Samiul Alam (18563323)