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101
Coevolving residues distant from the ligand binding site are involved in GAF domain function
Published 2025“…<p dir="ltr">Ligand binding to GAF domains regulates the activity of associated catalytic domains in various proteins, such as the cGMP-hydrolyzing catalytic domain of phosphodiesterase 5 (PDE5) activated by cGMP binding to GAFa domain. …”
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102
Exendin-4 promotes GSIS without increasing β-cell number through upregulation of glucose-sensing apparatus and mitochondrial oxidative phosphorylation machinery genes in hPSC-deriv...
Published 2023“…This consists of 6 stages: S1, definitive endoderm; S2, gut tube endoderm; S3, pancreatic progenitors 1; S4, pancreatic progenitors 2; S5, endocrine precursors; and S6, β-like cells. …”
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Lifetime prevalence, risk, and treatment of mood and anxiety disorders in Qatar's national mental health study
Published 2024“…Treatment contact in the year of disorder onset were 13.5%. The median delay in receiving treatment was 5 years (IQR = 2–13). …”
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105
Theoretical and experimental investigations of vanadium pentoxide–based electrocatalysts for the hydrogen evolution reaction in alkaline media
Published 2024“…This was reflected experimentally through kinetically non-ideal alkaline electrochemical HER using Zn<sub>0.4</sub>V<sub>1.6</sub>O<sub>5</sub> whereby − 194 mV of overpotential was required to attain − 10 mA/cm<sup>2</sup> of current density, as opposed to pristine V<sub>2</sub>O<sub>5</sub> which required 32% higher overpotential requirement at the same conditions. …”
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106
The molecular mechanisms of apoptosis accompanied with the epigenetic regulation of the NY-ESO-1 antigen in non-small lung cancer cells treated with decitabine (5-aza-CdR)
Published 2023“…These results reiterate the decisive role of 5-Aza-CdR in lung cancer treatment since it induces the epigenetic regulation of NY-ESO-1 antigen, inhibits cell proliferation, increases apoptosis, and decreases invasiveness.…”
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107
Age, Disease Severity and Ethnicity Influence Humoral Responses in a Multi-Ethnic COVID-19 Cohort
Published 2021“…As expected, patients with severe disease showed significantly higher antibody titers and interestingly also had significantly broader epitope coverage. A significant increase in antibody titer and epitope coverage was observed with increasing age, in both mild and severe disease, which is promising for vaccine efficacy in older individuals. …”
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108
Deciphering the In vitro Role of microRNAs miR-21-3p and miR-222-5p In the Regulation of Clostridioides difficile Flagellin-Induced Inflammation
Published 2024“…Western blot and pathway analyses demonstrated that miR-222-5p and miR-21-3p overexpression increased phosphorylation of p65, a key component of the NF-κB complex, while their knockdown reduced p65 phosphorylation. …”
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109
Role of Active Morphing in the Aerodynamic Performance of Flapping Wings in Formation Flight
Published 2021“…Migratory birds have the ability to save energy during flight by arranging themselves in a V-formation. This arrangement enables an increase in the overall efficiency of the group because the wake vortices shed by each of the birds provide additional lift and thrust to every member. …”
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110
Review on COVID-19 diagnosis models based on machine learning and deep learning approaches
Published 2021“…The exponential increase in the number of infections has rendered traditional diagnosis techniques inefficient. …”
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Predictors of prolonged hospitalization among geriatric trauma patients using the modified 5-Item Frailty index in a Middle Eastern trauma center: an 11-year retrospective study
Published 2025“…The female/male ratio was 17.5%/82.5%, and the mean injury severity score was 13 ± 9. …”
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113
The Identification Process & Tools for Gifted and Talented Students: Research on Five inclusive government schools in Ajman to study the areas of identification process tools utili...
Published 2016“…With the increase focus on innovation and creativity, the Giftedness Education has become embedded with the UAE government’s future strategies. …”
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114
Clinical reappraisal of the composite international diagnostic interview version 3.3 in Qatar's National Mental Health Study
Published 2024“…Recalibration of the short‐form PCL‐5 removed an initially significant difference in PTSD prevalence with the full PCL‐5 (from X<sup>2</sup><sub>1</sub>= 610.5, <i>p</i> < 0.001 to X<sup>2</sup><sub>1</sub>= 2.5, <i>p</i> = 0.110) while also increasing AU‐ROC from 0.76 to 0.81.…”
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115
Investigating the Stability of eLiposomes at Elevated Temperatures
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Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burd...
Published 2021“…Deaths of children younger than 5 years totalled 9·65 million (95% UI 9·05–10·30) in 2000 and 5·05 million (4·27–6·02) in 2019, with the neonatal fraction of these deaths increasing from 39% (3·76 million [95% UI 3·53–4·02]) in 2000 to 48% (2·42 million; 2·06–2·86) in 2019. …”
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Modeling and Performance Analysis of mmWave and WiFi-Based Vehicle Communications
Published 2024“…With the increasing demand for bandwidth in V2V services, exploring innovative solutions has become imperative. …”
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Follow‐Up and Comparative Assessment of SARS‐CoV‐2 IgA, IgG, Neutralizing, and Total Antibody Responses After BNT162b2 or mRNA‐1273 Heterologous Booster Vaccination
Published 2024“…Nevertheless, a heterologous booster led to an increase of ~12 times in the immune response when compared to two consecutive homologous ChAdOx1 immunizations. …”
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Association between body mass index (BMI) percentile and asthma in children of 5–12 years old: A case–control study using electronic medical records in Primary Health Care Corporat...
Published 2019“…Most epidemiological studies have proposed that a high body mass index (BMI) at infancy and early childhood increases the risk of asthma in children. A recently adopted electronic recording system for health service encounters in Primary Health Care Corporation of Qatar has provided a convenient opportunity to assess the possible link between asthma and obesity in children aged 5–12 years.…”