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481
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482
Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy
Published 2019“…Impaired protein degradation and increased levels of α-synuclein may trigger a pathological aggregation <i>in vitro</i> and <i>in vivo</i>. …”
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483
Theoretical and experimental investigations of vanadium pentoxide–based electrocatalysts for the hydrogen evolution reaction in alkaline media
Published 2024“…In recent years, there have been increasing efforts aimed at developing noble metal-free electrocatalysts that are earth-abundant and electroactive towards hydrogen evolution reaction (HER) in alkaline electrolytes, wherein an initial water dissociation step is followed by a two-electron transfer cathodic reaction. …”
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484
Biomarkers of COVID-19 severity may not serve patients with polycystic ovary syndrome
Published 2021“…Whilst the comparison with absolute disease-free normality is relevant, an increasing proportion of the population have insulin resistant states with associated metabolic conditions; an example of such a metabolic condition is polycystic ovary syndrome (PCOS) where it has been shown that protein expression patterns may differ compared to those without PCOS [3]. …”
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485
Performance analysis of a new PV array reconfiguration approach: Simulations and outdoor experiments under fixed and moving shadows
Published 2025“…<p dir="ltr">Partial shading can significantly impair photovoltaic (PV) array performance in large-scale systems, by reducing power output and increasing the complexity of wiring and maintenance. …”
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486
Friction stir extrusion of ultra-thin wall biodegradable magnesium alloy tubes — Microstructure and corrosion response
Published 2021“…For example, tubular devices such as coronary stents manufacture require defect-free, highquality tubes with thin walls (100 μm – 1 mm) as a precursor. …”
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487
Complete resection of the alar folds in eight standing horses with a bipolar dividing and vessel‐sealing device
Published 2020“…The surgery significantly improved race earnings and performance while avoiding the risk associated with general anesthesia and offered a short and complication‐free rehabilitation period.</p> <h3>Clinical impact</h3> <p>This study describes a surgical technique offering a novel approach to resection of the alar folds in the standing horse.…”
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488
Landscape of childhood epilepsies – A multi-ethnic population-based study
Published 2022“…At the last follow up, only 36% of patients were seizure-free and 12% (170/1422) had a history of status epilepticus. …”
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489
Comparative life cycle assessment of sustainable energy carriers including production, storage, overseas transport and utilization
Published 2021“…<p dir="ltr">Countries are under increasing pressure to reduce greenhouse gas emissions as an act upon the Paris Agreement. …”
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490
The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women
Published 2018“…Thyroid stimulating hormone (TSH) serum concentrations increased while free thyroxine (fT<sub>4</sub>) concentrations decreased with 3 months of SPI compared to SP supplementation for both men and women. rT<sub>3</sub> correlated with TSH in both studies (<i>p</i> = 0.03) but not with either fT<sub>3</sub> or fT<sub>4</sub>. fT<sub>3</sub> levels did not differ between the SPI and SP preparations.…”
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491
Intravenous administration of gold nanoparticles in rats exhibit alterations in sphingomyelins, bile acids, sphingolipids, and cholesterol esters levels
Published 2024“…Annotation of metabolites was determined by retention times and specific MRMs for each compound. Results indicate that AuNPs treatment significantly impacted several metabolic pathways. …”
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492
Global, regional, and national age-sex-specific burden of diarrhoeal diseases, their risk factors, and aetiologies, 1990–2021, for 204 countries and territories: a systematic analy...
Published 2024“…The most pronounced decline was in children younger than 5 years, with a 79·2% (72·4–84·6) decrease in diarrhoeal deaths. Global YLLs also decreased substantially, from 186 million (147–221) in 1990 to 51·4 million (39·9–65·9) in 2021. …”
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493
The effect of Hydrogen Peroxide treatments on dental enamel porosity and protein structure and its long-term implications on tooth hardness and optical properties
Published 2025“…<h3>Objective</h3><p dir="ltr">The aim of this study is to investigate how hydrogen peroxide (HP) treatments affect enamel porosity and protein structure, as well as their impact on tooth shade and hardness over time. </p><h3>Methods</h3><p dir="ltr">Fifty healthy teeth were collected from adult patients. …”
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494
Double versus triple arthrodesis for adult-acquired flatfoot deformity due to stage III posterior tibial tendon insufficiency: a prospective comparative study of two cohorts
Published 2022“…Secondary outcomes were operative time, time to union, and complications. The double arthrodesis was done through the medial approach, while the triple arthrodesis was done through dual medial and lateral approaches. …”
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495
Single-Cell Transcriptome Analysis Revealed Heterogeneity and Identified Novel Therapeutic Targets for Breast Cancer Subtypes
Published 2023“…Given the aggressive nature and lack of targeted therapies for TNBC, elevated expression of ENO1, FDPS, CCT6A, TUBB2A, and PGK1 predicted worse relapse-free survival (RFS) in basal BC (n = 442), while elevated expression of ENO1, FDPS, CCT6A, and PGK1 was observed in the most aggressive BLIS TNBC subtype. …”
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496
A multi-targeted approach to identify potential flavonoids against three targets in the SARS-CoV-2 life cycle
Published 2022“…These observations were complimented by the 100 ns molecular dynamics simulation and binding free energy analysis, which showed a considerable stability of docked bioflavonoids in the active site of SARS-CoV-2 target proteins. …”
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497
Deep learning-based cross-device standardization of surface-enhanced Raman spectroscopy for enhanced bacterial recognition
Published 2026“…<p dir="ltr">Surface-enhanced Raman spectroscopy (SERS) is a powerful, label-free technique for pathogen detection; however, its broader adoption in clinical diagnostics is hindered by inconsistent spectral quality across portable and laboratory-grade instruments, limited cross-device reproducibility, and the poor generalizability of existing machine learning approaches. …”
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498
Attitudes, motivators, and barriers toward influenza vaccination for children: a study from a conflict-ridden country
Published 2024“…<h3>Background</h3><p dir="ltr">Despite the increased recommendations for influenza vaccination, particularly among high-risk groups such as young children, Yemen lacks an influenza vaccination program, and the influenza vaccine is not included in the national immunization regime. …”
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499
10-Day structured initiation protocol from multiple daily injection to hybrid closed-loop system in children and adolescents with type 1 diabetes
Published 2020“…The participants used the sensor for a median of 92% of the time and spent a median of 89% in Auto Mode. The mean HbA1c decreased from 8.2 ± 1.4% (66 ± 15.3 mmol/mol) at baseline to 6.7 ± 0.5% (50 ± 5.5 mmol/mol) at the end of the study (p = 0.017). …”
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500
Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass index
Published 2021“…In addition, coagulation variables such as thrombin-activatable fibrinolysis inhibitor, plasminogen activator inhibitor-1 (PAI-1), D-dimer, Antithrombin and thrombomodulin have been reported to be elevated in PCOS compared to control subjects, and the functional coagulation tests including prothrombin time, thrombin time and fibrin degradation products may be predictive of PCOS. …”